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MEDICINUS

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Published by PT Dexa Medica

ISSN : 1979391X EISSN : 29638399 DOI : 10.56951

Core Subject : Health, Science,

Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

Tujuan penerbitan jurnal Medicinus adalah untuk meningkatkan wawasan dan menambah khasanah pengetahuan para praktisi medis dan farmasis di bidang kedokteran dan kefarmasian. Ruang lingkup dari jurnal ilmiah ini adalah publikasi artikel-artikel ilmiah yang bisa disajikan dalam bentuk penelitian (research), laporan kasus (case report), teknologi dan klinis kefarmasian, serta ulasan literatur medis.

Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)

Articles 8 Documents

Search results for , issue "Vol. 34 No. 1 (2021): MEDICINUS" : 8 Documents clear

Dislipidemia Aterogenik pada Pasien Diabetes Melitus Tipe 2: Patofisiologi dan Pilihan Terapi Rosandi, Rulli
MEDICINUS Vol. 34 No. 1 (2021): MEDICINUS
Publisher : PT Dexa Medica

Atherogenic dyslipidemia is characterized by increase in triglyceride and small dense lipoprotein (sdLDL) level and decrease in high-density lipoprotein (HDL) level. This condition is accompanied by increased TG-rich very-low-density lipoprotein, apolipoprotein B, and oxidized low-density lipoprotein (oxLDL). This lipid profile plays an important role in the pathogenesis of cardiovascular disorders such as coronary heart disease, peripheral artery disease, and stroke. Diabetes mellitus is an independent risk factor for premature atherosclerosis. High- and moderate-intensity statins are recommended therapeutic options in the management of this disorder. Currently, there are also some therapeutic options other than statin to accompany statin therapy. Ezetimibe and proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitor are mentioned a lot in current lipid management guidelines in addition to nonpharmacologic approach such as diet and physical exercise.

Faktor Risiko Disabilitas Berat pada Anak dengan Guillain-Barré Syndrome di RSUD Dr. Soetomo Surabaya Ratih Dwi Andini; Darto Saharso; Prastiya Indra Gunawan
MEDICINUS Vol. 34 No. 1 (2021): MEDICINUS
Publisher : PT Dexa Medica

Latar Belakang: Guillain-Barré Syndrome (GBS) merupakan penyebab paralisis neuromuskular akut yang paling sering ditemukan. Prognosis anak-anak dengan GBS pada umumnya tergolong baik, namun terdapat kemungkinan prognosis buruk yang membutuhkan ventilasi mekanis dan mengakibatkan terjadinya defisit neurologis. Penelitian ini bertujuan untuk mengamati faktor risiko disabilitas yang berpengaruh pada anak dengan GBS di RSUD Dr. Soetomo Surabaya. Metode: Penelitian ini menggunakan desain cross-sectional yang dilakukan pada anak dengan GBS, menggunakan data yang diperoleh dari rekam medis. Outcome pasien selama perawatan pada penelitian ini adalah sembuh, disabilitas, dan meninggal. Analisis statistik menggunakan uji Chi-Square dengan nilai signifikansi p<0,05. Hasil: Sebanyak 61 anak dengan GBS memenuhi kriteria inklusi selama masa studi penelitian. Anak laki-laki didapatkan sebanyak 54,1% dan infeksi saluran pernafasan atas merupakan penyebab paling sering (73,8% kasus). Mean usia pada penelitian ini adalah 8,4(±3,79) tahun. Sebagian besar jenis GBS adalah acute inflammatory demyelinating polyradiculoneuropathy (AIDP) yakni sebanyak 89,1% kasus. Hasil analisis menunjukan bahwa pasien GBS yang mengalami gagal napas dengan penggunaan ventilasi mekanis, menunjukkan odds ratio terjadinya disabilitas berat sebesar 8,9(1/0,112) kali lebih besar dibandingkan pasien yang tidak menggunakan ventilasi mekanis. Kesimpulan: Penggunaan ventilasi mekanis merupakan faktor risiko terjadinya disabilitas berat pada anak dengan GBS.

Hyperglycemia in Childhood Acute Lymphoblastic Leukemia during Induction Chemotherapy Nengcy Erlina Tasik Rerung; Cahyadi, Andi; Nur Rochmah; Maria Christina Shanty Larasati; Andarsini, Mia Ratwita; Muhammad Faizi; IDG Ugrasena; Bambang Permono
MEDICINUS Vol. 34 No. 1 (2021): MEDICINUS
Publisher : PT Dexa Medica

Introduction: Hyperglycemia is a well-known adverse effect of the corticosteroids and asparaginase given during induction chemotherapy for pediatric acute lymphoblastic leukemia (ALL). ALL is a type of hematologic malignancy with high incidence in the childhood. The aim of this study is to investigate the impact of hyperglycemia during induction chemotherapy in childhood ALL. Methods: This prospective study was done in Dr. Soetomo hospital from January to April 2018. The subject was newly diagnosed as ALL under the age of 18 years, treated with Indonesian childhood ALL 2013 protocol (standard risk (SR) group and high risk (HR) group). Hyperglycemia was defined as at least two separate random plasma glucose levels >200 mg/dL, which was evaluated before and during induction chemotherapy. Statistical analysis using Paired T-test for parametric and Wilcoxon test for nonparametric. Results: Thirty-three children were enrolled, 18/33 boys with mean age 5.8 (SD 3.78) years, compromised as ALL-L1 30/33. They were treated with ALL-HR 19/33 and ALL-SR 14/33. In overall groups, the mean random blood glucose level significantly increased from 108 (SD 21.3) mg/dl to 147 (SD 48.1) mg/dl, (mean difference 38.67 mg/dl; 95% CI 18.08 to 59.26 mg/dl, p=0.008). In SR group, there was a significant increase of mean random blood glucose level from 102 (SD 13.5) mg/dl to 133 (SD 37.3) mg/dl, (mean difference 31.8 mg/dl; 95% CI 8.78 to 54.8 mg/dl; p=0.01). In HR group, the mean random blood glucose level increased from 113 (SD 51.9) mg/dl to 165 (SD 25.4) mg/dl, (mean difference 51.9 mg/dl; 95% CI 18.6 to 85.2 mg/dl, p=0.004). Conclusion: Blood glucose level is significantly increase during induction chemotherapy in both SR and HR Indonesian childhood ALL 2013 protocol.

Laporan Kasus Acrodermatitis Enteropathica pada Anak 5 Tahun dengan Level Zink Serum Normal Nareswari, Adniana; Mochtar, Moerbono; Widhiati, Suci; Kusumawardani, Arie; Ellistasari, Endra Yustin; Julianto, Indah
MEDICINUS Vol. 34 No. 1 (2021): MEDICINUS
Publisher : PT Dexa Medica

Acrodermatitis enterophatica (AE) is an inherited or acquired condition associated with zinc malabsorption. Clinical symptoms of AE are periorificial and acral dermatitis, alopecia, and diarrhea. Serum zinc levels usually decrease in AE patients. A 5-year-old boy presented with crusted erosion on the face, trunks and extremities that have been appeared for one year and worsened last month. It also accompanied by hair and eyebrow loss, diarrhea, and eating disorder. Patient was also malnourished. Dermatovenereology examination showed papules, patches, multiple erythematous plaques with squama, erosions with brownish yellow crust above located on perioral, periorbital, posterior trunk, inguinal, perianal, cubital, popliteal and dorsum pedis region. The oral region showed stomatitis and cheilitis. The orbital region showed conjunctival injection and eye discharge. The scalp, eyebrows and lashes showed total alopecia. Laboratory test showed normal serum zinc levels and decreased levels of alkaline phosphatase. The patient was diagnosed with acquired form of AE. Clinical improvement was seen after zinc supplementation. The diagnosis of AE cannot be made only by low serum zinc levels. If a classical triad of AE was found, we must be able to recognize it immediately, thus prompt and appropriate therapy could be given.

Terapi Doxycycline pada Laki-laki Homoseksual dengan Sifilis Sekunder dan Infeksi Human Immunodeficiency Virus Anggana Rafika Paramitasari; Imroatul Ulya; Agung Triana Hartati; Susanti Rosmala Dewi; Prasetyadi Mawardi
MEDICINUS Vol. 34 No. 1 (2021): MEDICINUS
Publisher : PT Dexa Medica

Background: Re-emergence of syphilis is increasing especially among MSM (men who have sex with men) patients. Syphilis in HIV-infected patients is reported to show faster and higher risk for progression to neurosyphilis. Co-infection of syphilis and human immunodeficiency virus (HIV) is correlated with decrease in CD4 and increase in HIV-RNA. Doxycycline has an antiinflammatory effect associated with decrease of HIV-RNA and increase of CD4 in HIV patients. Case: A 20 years old foreigner MSM man complained about non-itchy red spots throughout his body for 2 days with slight fever. He has a history of more than 10 sexual partners and rarely use condom. Physical examination revealed various sizes of erythematous macules and papules on his trunk and extremities. We found erythematous plaques with regular border but no ulcer on his scrotum and no secrete from his urethra. There was enlargement in the inguinal lymph node. VDRL and TPHA examinations were 1:32 and 1:640, respectively. HIV test was reactive with CD4 value 558 cells/ml. Treatment consists of doxycycline 2x100 mg for 14 days and also ARV (nevirapine, lamivudine and zidovudine). His symptoms were improved after a month accompanied with decreased VDRL to 1:2 and slightly increased CD4 to 570 cells/ml. Discussion: Doxycycline is a second line treatment for syphilis that is known to help decreasing the viral load and increasing CD4 level in syphilis with HIV. A significant decrease in VDRL titer in this patient indicates a successful therapy.

Anestesi Spinal Levobupivacaine Isobarik pada Sectio Caesarea Nasman Puar
MEDICINUS Vol. 34 No. 1 (2021): MEDICINUS
Publisher : PT Dexa Medica

Sectio caesarea (SC) atau operasi sesar merupakan metode persalinan di mana janin dilahirkan melalui insisi pada dinding rahim. Menurut WHO, jumlah tindakan sectio caesarea pada tahun 2011 dilaporkan mengalami peningkatan 5 kali dibandingkan dengan tahun-tahun sebelumnya. Penggunaan teknik anestesi yang aman dan efektif pada tindakan sectio caesarea membutuhkan pemahaman yang menyeluruh mengenai perubahan fisiologi yang terjadi pada kehamilan, proses melahirkan, dan kelahiran bayi. Salah satu agen anestesi lokal yang sering digunakan untuk anestesi spinal adalah bupivacaine. Bupivacaine adalah obat anestesi lokal jenis amida yang memiliki masa kerja panjang dan mula kerja yang pendek. Bupivacaine merupakan campuran rasemat dari isomer optik levobupivacaine dan dextrobupivacaine dengan perbandingan yang sama, yang dikenal juga sebagai enantiomer S(-) dan R(+). Levobupivacaine adalah enantiomer S(-) murni dari bupivacaine dengan profil toksisitas yang lebih minimal terhadap sistem saraf dan kardiovaskular. Penelitian menunjukkan bahwa penggunaan levobupivacaine isobarik pada pasien yang menjalani tindakan sectio caesarea menghasilkan efek yang sebanding dengan bupivacaine hiperbarik dengan profil keamanan yang lebih baik.

Manifestasi Klinis Covid-19 pada Kulit Iswinarno Doso Saputro; Medisa Primasari
MEDICINUS Vol. 34 No. 1 (2021): MEDICINUS
Publisher : PT Dexa Medica

Severe acute respiratory syndrome Coronavirus-2 (SARS-CoV-2) is a strain of coronavirus that causes Coronavirus Disease 2019 (Covid-19). The first case was reported in the city of Wuhan, China, through the consumption of bush meat which presumed to be the reservoir of the virus. Human-to-human transmission occurs through respiratory droplet inhalation or touching contaminated surfaces, then without washing hands, virus may enter the body through contact with mucous membrane in the eyes, nose, or mouth. Covid-19 manifested in various level of severity among individuals, from mild, severe, critical, or even symptom-free. Clinical manifestations are not specific and vary among individuals. Common symptoms are fever, cough, fatigue, shortness of breath, upper respiratory symptoms, gastrointestinal disorders, loss of taste or smell, also presentation of skin manifestation. Skin manifestation associated with Covid-19 also varies and may appear at different times without being followed by other symptoms. Laboratory tests, imaging test, and identification of genetic material of SARS-CoV-2 are necessary to confirm the diagnosis of COVID-19.

Breast Lumpectomy Surgery by Pectoral Nerve Block (Pecs Block) without General Anesthesia – A Case Report Ida Bagus Reza Nanda Iswara; Wayan Widana
MEDICINUS Vol. 34 No. 1 (2021): MEDICINUS
Publisher : PT Dexa Medica

Breast conserving surgery is usually performed under general anesthesia, or more recently combined with regional anesthesia techniques. Thoracic spinal block, thoracic epidural block, and thoracic paravertebral block are options of regional anesthesia that have been used in breast surgery, but anesthesiologists avoid them due to concern in potency of complications and side effects. After introduced by Blanco in 2011, pectoral nerves (Pecs) block appears as alternative procedure with fewer complications and lower incident of postoperative pain. In this case report we describe a 32-year-old female patient admitted for elective lumpectomy of the left upper quadrant of the breast. Ultrasound guided Pecs II block was chosen as the anesthetic technique for this patient. The authors reported succesful management of anesthesia and pain without complications in breast surgery. Pecs II block as single anesthetic technique can be considered safe, advantageous, and effective in breast surgery with good hemodinamic stability and few side effects.

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Ratna Kumalasari

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Home Page

OAI Link

Editorial Team

Contact

Reviewer

Google Scholar

Contact Name Ratna Kumalasari

Contact Email medicinus@dexagroup.com

Phone +6287808191388

Journal Mail Official medicinus@dexagroup.com

Editorial Address Gedung Titan Center 5th Floor, Jl. Boulevard Bintaro B7/B1 No. 5, Bintaro Jaya Sektor 7, Pokdok Aren, Tangerang Selatan 15224

Location Kota tangerang selatan, Banten INDONESIA

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Contact Name
Ratna Kumalasari

Contact Email
medicinus@dexagroup.com

Phone
+6287808191388

Journal Mail Official
medicinus@dexagroup.com

Editorial Address
Gedung Titan Center 5th Floor, Jl. Boulevard Bintaro B7/B1 No. 5, Bintaro Jaya Sektor 7, Pokdok Aren, Tangerang Selatan 15224

Location
Kota tangerang selatan,

Banten

INDONESIA