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Ratna Kumalasari
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INDONESIA
MEDICINUS
Published by PT Dexa Medica
ISSN : 1979391X     EISSN : 29638399     DOI : 10.56951
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health
Tujuan penerbitan jurnal Medicinus adalah untuk meningkatkan wawasan dan menambah khasanah pengetahuan para praktisi medis dan farmasis di bidang kedokteran dan kefarmasian. Ruang lingkup dari jurnal ilmiah ini adalah publikasi artikel-artikel ilmiah yang bisa disajikan dalam bentuk penelitian (research), laporan kasus (case report), teknologi dan klinis kefarmasian, serta ulasan literatur medis.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 7 Documents
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Search results for , issue "Vol. 35 No. 3 (2022): MEDICINUS" : 7 Documents clear
Manajemen Kanker Kolorektal Agi Satria Putranto
MEDICINUS Vol. 35 No. 3 (2022): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56951/medicinus.v35i3.99

Abstract

Colorectal cancer was infrequently diagnosed few decades ago, but the number of cases increased dramatically until it becomes the third most prevalent malignancy after breast and lung cancer. Population aging and on top of unhealthy lifestyle were major contributor to the significant rise of the disease. Management of colorectal cancer has markedly evolved, allowing improvement in terms of survival and advance in quality of life. Nevertheless, the rate of survival could be boosted by raising public awareness over colorectal cancer, education program that may lead to better health behaviour, as well as health system policy that support disesase screening, considering the characteristic of the disease that is often asymptomatic, particularly in the early development.
Pengaruh Pemberian Produk Olahan Kacang Kedelai terhadap Glukosa Darah Puasa dan Resistansi Insulin pada Model Tikus Diabetes Melitus Kendra Hosea; Supriyanto Kartodarsono; Arifin; Sumardi
MEDICINUS Vol. 35 No. 3 (2022): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56951/medicinus.v35i3.102

Abstract

Background: Diabetes mellitus (DM) is a chronic condition that requires continuous medical care with multifactorial management strategy. Soybean is known as source of isoflavones that possess beneficial effect to help controlling blood glucose level. This study aims to evaluate the effect of soybean product diet to reduce fasting blood glucose and improve insulin resistance. Methods: This is an experimental study using 30 streptozotocin-induced diabetic Wistar rats that divided into 5 groups, i.e. normal rats, negative control, and three treatment groups that receive tempeh, tofu, and soy flour diet for 2 weeks. Fasting blood glucose was tested before treatment, after diabetes induction, and at the end of the study. HOMA-IR was calculated using fasting blood glucose and fasting insulin level after diabetes induction and at the end of the study. MANOVA test was used to analyzed the data statistically (p<0,05). Results: There was a significant effect from soybean product diet (tempeh, tofu, and soy four) in reducing fasting blood glucose and HOMA-IR, with slightly better result shown in tempeh group. Conclusion: Soybean product such as tempeh, tofu, and soy flour have beneficial effect in reducing fasting blood glucose and improving insulin resistance in streptozotocin-induced diabetic rats.
Thoracal Segmental Spinal Anesthesia for Lower Back Lipoma Excision Christanto Suryo; I Wayan Widana
MEDICINUS Vol. 35 No. 3 (2022): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56951/medicinus.v35i3.103

Abstract

Background: General anesthesia is the most preferred anesthetic management for lower back surgery, considering the location and practicality. However, multiple studies showed that regional anesthesia, particularly thoracal segmental, spinal anesthesia, had more advantages compared to general anesthesia. Case presentation: We report a 19-year-old woman admitted to the OR for infected lipoma in lower back region, located in thoracal 12th, who underwent successful thoracal segmental spinal anesthesia. Conclusion: This is an original case report which showed significance of thoracal segmental spinal anesthesia and the advantages compared to general anesthesia.
Sistem Penghantaran Obat dengan Misel Polimer Alasen Sembiring Milala
MEDICINUS Vol. 35 No. 3 (2022): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56951/medicinus.v35i3.104

Abstract

Today is the era of nanotechnology, where almost all fields use nanotechnology. Likewise, the field of pharmaceutical technology is currently intensively developing pharmaceutical preparations using nanosystem. One of these nanosystems is polymeric micelles, which generally have particle size below 100 nm. Research showed that polymeric micelles have been proven to increase the solubility and bioavailability of hydrophobic drugs. There are several methods that can be used in polymeric micelles preparation, each of which has advantages and disadvantages. In order to characterize polymer micelles, parameter evaluation includes determination of critical micelle concentration (CMC), particle size, surface characteristics, stability, and release tests. Although most of the research on polymer micelles was applied in the field of oncology by the intravenous route of administration, researchers are currently developing drug delivery system using polymer micelles for oral route of administration. It can be further expected to initiate clinical research like such that has been done on intravenous administration.
Modalitas Terapi Vitiligo pada Anak Nathania Amelinda; Endra Yustin Ellistasari; Indah Julianto
MEDICINUS Vol. 35 No. 3 (2022): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56951/medicinus.v35i3.106

Abstract

itiligo is a pigmentation disorder characterized by depigmented patches on skin and hair due to functional loss of melanocytes. Vitiligo in children is generally associated with other autoimmune diseases and has serious cosmetic and psychosocial impact. Treatment modalities for vitiligo in children consist of topical therapy, phototherapy, systemic therapy, and surgery. Vitiligo in children has a relatively good prognosis compared to adult cases. Repigmentation in childhood vitiligo usually happen spontaneously and relapses are rare.
Pemeriksaan Aldosterone/Renin Ratio sebagai Prediktor Penyakit Ginjal Kronis pada Penderita Hipertensi Juliani Dewi
MEDICINUS Vol. 35 No. 3 (2022): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56951/medicinus.v35i3.107

Abstract

The prevalence of chronic kidney disease (CKD) is increasing. Hypertension is an established risk factor of CKD, yet found prevalent in Indonesia. To date, there is no test that can be used as predictor of , especially hypertensive patients. Recently, the relationship between aldosterone level (plasma aldosterone concentration/PAC) with hypertension and CKD has been extensively studied. Advanced studies have found that aldosterone/renin ratio (ARR) can be a promising parameter to predict the occurrence of CKD. This result brings hope for hypertensive patients, as we are able to predict not only the occurrence of CKD, but also the probability of cardio- and/or cerebrovascular events. Particularly for East Asia ethnic groups that are known to consume a relatively high amount of salt, ARR could also be a marker of salt intake sensitivity that may lead to a proper salt restriction in daily diet.
Pendekatan Multiperspektif dalam Manajemen Penyakit Asma Dito Anurogo
MEDICINUS Vol. 35 No. 3 (2022): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56951/medicinus.v35i3.108

Abstract

Asthma is a chronic inflammatory disorder of the respiratory tract. This scientific review aims to provide comprehensive explanation about asthma, including epidemiology, etiology, diet and nutrition, genetic and epigenetic factor, pathophysiology, asthma control evaluation, imaging, management, and trend toward novel therapy in the future, such as nanotechnology.

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