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MEDICINUS
Published by PT Dexa Medica
ISSN : 1979391X     EISSN : 29638399     DOI : 10.56951
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health
Tujuan penerbitan jurnal Medicinus adalah untuk meningkatkan wawasan dan menambah khasanah pengetahuan para praktisi medis dan farmasis di bidang kedokteran dan kefarmasian. Ruang lingkup dari jurnal ilmiah ini adalah publikasi artikel-artikel ilmiah yang bisa disajikan dalam bentuk penelitian (research), laporan kasus (case report), teknologi dan klinis kefarmasian, serta ulasan literatur medis.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 7 Documents
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Search results for , issue "Vol. 38 No. 6 (2025): MEDICINUS" : 7 Documents clear
Tiga Pilar Pertahanan Tubuh Terhadap Influenza: Vaksin, Terapi Antivirus, dan Imunomodulator dalam Perspektif Kedokteran Preventif dan Kuratif Raymond R Tjandrawinata
MEDICINUS Vol. 38 No. 6 (2025): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56951/dkbt5b68

Abstract

Influenza is an acute respiratory infection that continues to pose a global health threat due to its high morbidity and mortality burden. In order to overcome this challenge effectively, an integrative approach is required, encompassing three main pillars: annual vaccination adapted to virus mutation dynamics, the use of antiviral agents targeting viral RNA replication, and immune system strengthening through herbal-based immunomodulators and essential micronutrients. This paper emphasizes the importance of synergy between preventive and curative efforts in modern public health strategies.Immunomodulation, which includes a combination of phytocomponents with vitamin C and zinc, has been shown to enhance innate and adaptive immune responses, improve protection to infection, and support recovery processes.An evidence-based approach integrating these three elements is considered the most relevant strategy for addressing influenza virus evolution and strengthening the population's immunological resilience.
Hepatitis B and Hepatocellular Carcinoma: A Case Report and Literature Review Rendi Aji Prihaningtyas; Muhammad Irawan; Qurrota Ayuni Novia Putri; Bagus Setyoboedi; Sjamsul Arief
MEDICINUS Vol. 38 No. 6 (2025): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56951/e6bqh839

Abstract

Introduction: Current data estimates that over 90% of primary liver tumors are hepatocellular carcinomas (HCC), a type of malignant hepatocyte tumor. Viral hepatitis B is particularly associated with HCC. Early detection of chronic hepatitis B is crucial to prevent complications. Case Presentation: A 17-year-old girl presented with a one-month history of abdominal enlargement, jaundice, dark urine, and pale-colored stool. She experienced weight loss and a lack of appetite. Anthropometric assessment indicated severe malnutrition. The abdomen appeared distended with ascites. There was a palpable liver, with a firm consistency and a lumpy surface up to the epigastrium, with a size of 8 x 7 x 6 cm, and accompanied by splenomegaly. Laboratory examination indicated anemia (hemoglobin 9.5 g/dl), white blood cells 12.38 x 10³/μl, platelets 859 x 10³/μl, AST 1,095 U/l, ALT 104 U/l, cholestasis (total bilirubin 66.5 mg/dl and direct bilirubin 4.14 mg/dl), hypoalbuminemia (albumin 2.81 g/dl), LDH 3146 U/l, reactive HBsAg >1,000, AFP >1,000 ng/ml. An abdominal ultrasound revealed hepatomegaly with multiple nodules distributed across nearly all liver segments, and some of which formed a mass measuring 7.9 x 6.4 x 5.8 cm in the right lobe. Additionally, splenomegaly and ascites were observed. CT scan of the abdomen showed masses distributed throughout the hepatic lobe with contrast enhancement in the arterial phase and feeding from hepatic artery, in the venous phase, contrast washout with ascites. These findings support the diagnosis of hepatocellular carcinoma. Conclusion: Children with HBV may have had prior medical visits without being accurately diagnosed, representing missed opportunities for timely HBV detection. There is a critical need for increased awareness and early screening for hepatitis B virus (HBV) infection in children, especially in regions where HBV prevalence is high.
Di Balik Peradangan: Tinjauan tentang Peran Antinosiseptif Sel Imun dalam Modulasi Nyeri Raymond R. Tjandrawinata
MEDICINUS Vol. 38 No. 6 (2025): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56951/zxrk2y26

Abstract

Immune cells have long been considered antagonists in pain physiology, as they have largely been viewed primarily through the lens of inflammation and nociceptive amplification. However, emerging research is reshaping this narrative. This article describes the evolving role of immune cells — not merely as proinflammatory molecules, but also as agents involved in pain modulation and suppression. Recent findings in neuroimmunology reveal a complex molecular dialogue between immune mediators and nociceptive pathways, particularly highlighting the contributions of regulatory T cells, macrophage subtypes, and glial cells in reducing nociceptive signals. Antinociceptive mechanisms mediated by cytokines, lipid-derived mediators, and immune-to neuronal communication are reviewed along with their translational potential in chronic pain therapy. By redefining the role of immune cells into central figures in the analgesic process, a paradigm shift is emerging, which requires an integrative approach in pain research and therapy.
Perkembangan Terkini Penyakit Influenza dan Peran Favipiravir dalam Tata Laksana Penyakit Anna Rozaliyani; Asiyah Taqiyya Fakhrur Razi; Ammar Abdurrahman Hasyim; Findra Setianingrum; Rulliana Agustin; Erlang Samudro; Alvin Kosasih
MEDICINUS Vol. 38 No. 6 (2025): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56951/3trygg29

Abstract

Influenza virus infection remains a major global health challenge, particularly for vulnerable groups with compromised immune systems. Influenza is primarily caused by infection of influenza A and B viruses, with a varying clinical spectrum, ranging from asymptomatic cases to life-threatening conditions. Influenza viruses tend to undergo rapid genetic mutations, limiting the long-term effectiveness of vaccine-induced immune responses. Diagnosing influenza remains challenging due to the nonspecific signs and symptoms of the disease. The gold standard for influenza diagnosis is reverse transcription polymerase chain reaction (RT-PCR) test. Antiviral drugs are an essential prophylactic and therapeutic strategy to reduce influenza-related morbidity and mortality, especially in high-risk populations. Favipiravir has the potential to be a promising therapy against influenza, SARS-CoV-2, and other RNA virus infections. Prevention and control of influenza virus infections, including vaccination, are management strategies that must be optimized.
Perbandingan Keputusan Tata Laksana Farmakologi dan Rujukan Pasien Epilepsi Baru dengan Pasien yang Pernah Didiagnosis Sebelumnya pada Layanan Telemedik di Indonesia Pukovisa Prawiroharjo; Yulia Puspita Dewi
MEDICINUS Vol. 38 No. 6 (2025): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56951/qvn39698

Abstract

Introduction: Epilepsy is a condition or brain disorder characterized by a tendency for recurrent seizures. Telemedicine services use electronic communication facilities to provide medical support or care remotely. In these services, various factors influence doctors in making decisions. Objective: This study aims to compare the pharmacological management decisions and referral decisions for newly diagnosed epilepsy patients versus patients previously diagnosed by doctors in telemedicine services in Indonesia. Methods: This research uses a retrospective cross sectional design using secondary data sources from one of Indonesia's telemedicine services. A total of 100 subjects were selected within the telemedicine service. Pharmacological management decisions and referrals were assessed based on chat history. Results: Analysis of the data showed no significant difference between newly diagnosed patients and previously diagnosed in terms of pharmacological management decisions (p=0.298). However, there is a significant difference between newly diagnosed patients and previously diagnosed in terms of referral decisions (p=0.025). In addition, newly diagnosed patients appear to have a higher referral percentage (18.87%) compared to previously diagnosed patients (4.26%). Discussion: There was no significant difference in pharmacological treatment decisions between newly diagnosed patients and previously diagnosed patients. However, a significant difference was observed in referral decisions. This indicates the need for a larger sample size and further research.  
Analisis In Silico Interaksi antara Interferon Beta dengan Senyawa Turunan Flavonoid dan Terpenoid dari Bunga Carthamus tinctorius Lismayana Hansur; Nurmasita; Paisal; Sandy Vitria Kurniawan
MEDICINUS Vol. 38 No. 6 (2025): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56951/nej0dw97

Abstract

Background: Kasumba turatea (Carthamus tinctorius) has long been empirically used by the people of South Sulawesi as a traditional medicine for diseases caused by viral infections. This plant is known to contain compounds such as thymol, carvacrol, carthamon, chalcone, and linalool, which have potential immunomodulatory activity, including relevance to multiple sclerosis. One of the immune mechanisms which play a role is interferon beta (IFN-β), whose function is influenced by β-glucan, which can enhance IFN-β expression. Objective: This study aims to explore the interaction between thymol, carvacrol, carthamon, chalcone, and linalool — compounds with immunomodulatory— and IFN-β through acomputational (in silico) approach. Methods: The method used in this study is molecular docking using AutoDock Tools, AutoDock Vina, and Discovery Studio applications. The 3D structure of interferon beta was obtained from the Protein Data Bank (PDB) with PDB ID 1AU1. Beta-D-glucan (BDG) was used as the control compound. The ligands examined included carthamon, carvacrol, chalcone, linalool, and thymol. Results: Docking results showed that carthamon exhibitedthe highest binding affinity among the ligands. Key residues involved in ligand interaction at the active site of IFN-β were glutamic acid 42, arginine 28, serine 13, asparagine 90, and leucine 9, which interacted via hydrogen bonds. Conclusion:This study provides preliminary evidence that active compounds from kasumba turatea, particularly carthamon, have the potential to interact wit IFN-β. These findings can serve as a foundation for further research to examine the interaction of carthamon with IFN-β, which could enhance immunomodulatory capabilities.
Uji Klinik Terdesentralisasi: Mendefinisikan Ulang Partisipasi, Kuasa, dan Presisi dalam Riset Kesehatan Raymond R. Tjandrawinata
MEDICINUS Vol. 38 No. 6 (2025): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56951/trzykz54

Abstract

Decentralized clinical trials (DCTs) have emerged as a transformative force in biomedical research, breaking down traditional boundaries and reshaping how evidence is generated, validated, and applied. By leveraging digital health technologies, real-world data, and remote engagement infrastructures, DCTs have the potential to democratize clinical research by improving inclusivity and accessibility. However, these opportunities come with challenges related to regulatory governance, technological ethics, and socio-political representation. This brief article explores both the conceptual and empirical foundations of DCTs, drawing from recent studies, international policy documents (such as white papers), regulatory initiatives, and global practice surveys. It examines the epistemological, operational, and normative shifts introduced by DCTs and proposes a framework for understanding their impact on three core dimensions of clinical science: participation, power, and precision. Ultimately, this article argues that DCTs are not merely a digital enhancement, but rather a fundamental reconfiguration of how health knowledge is generated and governed.

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