cover
Article Per Year (5 Year)
All
Home Page
OAI Link
Editorial Team
Contact
Reviewer
Google Scholar
Contact Name
Ratna Kumalasari
Contact Email
medicinus@dexagroup.com
Phone
+6287808191388
Journal Mail Official
medicinus@dexagroup.com
Editorial Address
Gedung Titan Center 5th Floor, Jl. Boulevard Bintaro B7/B1 No. 5, Bintaro Jaya Sektor 7, Pokdok Aren, Tangerang Selatan 15224
Location
Kota tangerang selatan,
Banten
INDONESIA
MEDICINUS
Published by PT Dexa Medica
ISSN : 1979391X     EISSN : 29638399     DOI : 10.56951
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health
Tujuan penerbitan jurnal Medicinus adalah untuk meningkatkan wawasan dan menambah khasanah pengetahuan para praktisi medis dan farmasis di bidang kedokteran dan kefarmasian. Ruang lingkup dari jurnal ilmiah ini adalah publikasi artikel-artikel ilmiah yang bisa disajikan dalam bentuk penelitian (research), laporan kasus (case report), teknologi dan klinis kefarmasian, serta ulasan literatur medis.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 6 Documents
 1 
Search results for , issue "Vol. 38 No. 8 (2025): MEDICINUS" : 6 Documents clear
Laporan Kasus: Tantangan dalam Manajemen Epilepsi Katamenial pada Menstruasi Tidak Teratur Gabriella, Nadia; Kennytha Yoesdyanto
MEDICINUS Vol. 38 No. 8 (2025): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56951/kmv0je25

Abstract

Introduction: Catamenial epilepsy (CE) is characterized by periodic seizures, defined as ≥2-fold increase in seizure frequency during a specific period of the menstrual cycle. The prevalence of CE ranges from 10 to 70%, affecting over 40% of women with epilepsy. It is particularly prevalent among women with focal epilepsy, especially in cases of temporal lobe epilepsy (TLE). Exacerbation of seizures in CE is attributed to the fluctuations in reproductive steroid levels, which affect neuronal excitability. As of now, there is no definitive treatment available for CE. We reported a case of CE in a female patient with TLE.Case Report: A 20-year-old female patient with irregular periods presented with cluster seizures occurring within three days of her menstrual period. Seizure semiology is described as focal to generalized tonic-clonic seizures, with rightsidelateralization. No neurological deficits were found. Brain magnetic resonance imaging showed no abnormality. The electroencephalogram revealed sharp waves in both left and right temporal lobe. The patient was already treated with phenytoin 400 mg/day. However, due to persistence of seizures during the perimenstrual period, clobazam 20 mg/day was added. Seizure frequency has decreased but the patient remains under close observation.Discussion: The patient has been diagnosed with CE due to the cyclic exacerbation of seizures coinciding with her menstrual cycle. Her seizures consistenly occur within the perimenstrual phase, which is marked by a sudden withdrawal of progesterone and corresponding increase in seizure frequency. The recommended approach involves administering an add-on antiepileptic drug (AED) prior to and during menstruation. However, given the patient’s irregular periods, the mainchallenge lies in determining the optimal timing for this intervention.
The Role of Systemic Immune-Inflammation Index on The Clinical Degree of Dengue Hemorrhagic Fever Patients at Bethesda Hospital Yogyakarta Amumpuni, Antonia Namelia Wahyu; Sooai, Christiane Marlene; Wicaksono, Hendi; Probowati, Wiwiek; Priskila, Loury
MEDICINUS Vol. 38 No. 8 (2025): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56951/y6daha15

Abstract

Background: Dengue hemorrhagic fever (DHF) is a mosquito-borne infectious disease caused by the dengue virus and transmitted primarily by Aedes aegypti. According to the World Health Organization (WHO), DHF remains a major globalhealth concern, particularly in tropical and subtropical regions. The disease can result in severe complications, including hemorrhage and hypovolemic shock, which may lead to death. Despite ongoing vector control initiatives, DHF continues to pose a significant public health challenge, especially in areas with inadequate sanitation and limited healthcare infrastructure.Objectives: To evaluate the role of systemic immune-inflammation index (SII) in determining the clinical severity of denguehemorrhagic fever (DHF) among patients at Bethesda Hospital Yogyakarta.Methods: This was a cross-sectional study utilizing medical records from 333 DHF patients at Bethesda Hospital Yogyakarta. Records were screened based on predefined inclusion and exclusion criteria. A total of 172 eligible cases were selected using odds ratio-based sample size calculations. Consecutive sampling was employed as the samplingtechnique. Data analysis was performed using SPSS and Microsoft Excel to determine statistical significance.Results: The findings demonstrated that neutrophil, lymphocyte, and platelet counts significantly influenced the clinical severity of dengue hemorrhagic fever (DHF). Chi-square analysis revealed a statistically significant association between the systemic immune-inflammation index (SII) and disease classification (DF/DHF) (p<0.001). However, the relationshipbetween SII levels and clinical severity did not follow a linear pattern. Contrary to established theories—where elevated SII values are typically associated with increased disease severity—this study observed variations that may be attributed toconfounding factors such as patient age, comorbidities, and individual immune response.Conclusion: The systemic immune-inflammation index (SII) is significantly associated with the clinical severity of DHF in patients at Bethesda Hospital Yogyakarta, although its correlation may be influenced by additional patient-specificvariables such as patient age, comorbidities, and individual immune responses.Keywords: systemic immune-inflammation index (SII), dengue hemmorhagic fever (DHF), dengue severity, clinicalseverity.
Persistent Jaundice in a Tuberculosis Patient After Treatment: A Rare Case of Primary Sclerosing Cholangitis Endro Tanoyo; Fahmi Indrarti; Deshinta Putri Mulya; Nur Rahmi Ananda; Naomi Yoshuantari; Bestari Ariningrum Setyawati
MEDICINUS Vol. 38 No. 8 (2025): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56951/9gdf2175

Abstract

Primary sclerosing cholangitis (PSC) presents diagnostic challenges due to its overlapping features with other conditions. This case report describes a 28-year-old woman with a history of pulmonary tuberculosis who developed jaundice weeks after completing antituberculosis treatment, initially resembling drug-induced liver injury (DILI). In 2021, patient was diagnosed with tuberculous sclerosing cholangitis and showed improvement with antituberculosis therapy. However, in 2022, patient experienced recurrent jaundice, fever, dark urine, and weight loss, without gastrointestinal symptoms. Laboratory tests revealed elevated bilirubin (total 13.8 mg/dl, direct 12.9 mg/dl), increased liver enzymes (SGOT 177 U/l, SGPT 91 U/l), and a positive antinuclear antibody indirect immunofluorescence (ANA IF) test with a centromere pattern. Magnetic resonance cholangiopancreatography (MRCP) and liver biopsy findings supported a diagnosis of PSC, overlapping with tuberculous sclerosing cholangitis. Treatment with ursodeoxycholic acid, methylprednisolone, and mycophenolic acid led to significant improvement in bilirubin and liver enzyme levels, although they remained above the normal range. This case highlights the diagnostic complexity of PSC in tuberculosis patients, particularly in the absence of typical gastrointestinal symptoms. The relationship between tuberculosis and PSC remains unclear, necessitating further investigation. Despite treatment, serum bilirubin and transaminase levels were fluctuated but persisted above the normalrange, highlighting the challenges in managing PSC with concurrent tuberculosis. This report emphasizes the importance of comprehensive diagnostic approaches, including imaging and histopathology, in identifying atypical presentations of PSC.
Pendekatan Integratif dalam Manajemen Dengue Raymond R. Tjandrawinata
MEDICINUS Vol. 38 No. 8 (2025): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56951/699q0n64

Abstract

Dengue, as one of the most challenging tropical diseases of the 21st century, continues to present significant clinical and epidemiological complexities in developing countries, including Indonesia. With the increasing incidence of global dengue infections and the limited availability of definitive therapeutic options, clinical management is shifting toward optimizing supportive therapy and exploring adjuvant strategies to improve key clinical parameters such as hemodynamic and platelet count. By emphasizing the role of two interventions, Gelafusal (gelatin solutions) as a colloid fluid for resuscitation and Psidii (Psidium guajava folium extracts) as a platelet production-stimulating agent, through the lens of bioethics, pharmacodynamics, and evidence-based clinical strategies, this review offers a critical reflection on the opportunities and limitations of applying multimodal interventions in dengue management.
Update Manajemen Perioperatif pada Gangguan Tiroid dan Adrenal Brilliant Van Fitof S.R.
MEDICINUS Vol. 38 No. 8 (2025): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56951/6n8rts34

Abstract

Surgical patients with endocrine disorders require special consideration during perioperative evaluation and postoperative management. Several endocrine disorders encountered in the perioperative period include thyroid and adrenal diseases. Both conditions require optimal perioperative preparation to ensure that intraoperative and postoperative interventions proceed without complications. This preparation involves the collaboration of various medical disciplines, ranging from primary care physicians to consultant physicians in the hospitals. Patients with thyroid disorders require thorough preoperative assessment to prevent complications such as thyroid storm, which may occur during or after surgery. A similar approach is essential for patients with adrenal insufficiency. This article discusses the perioperative management in endocrine disorders, particularly thyroid and adrenal diseases, to enable clinicians such as surgeons, anesthesiologists, and internists provide appropriate therapeutic approaches for patients.
Inovasi dan Praktik Terbaik dalam Model Tikus Hasil Rekayasa Genetik untuk Penelitian Praklinis dan Translasional Raymond R. Tjandrawinata
MEDICINUS Vol. 38 No. 8 (2025): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56951/26jxqx92

Abstract

Genetically engineered mouse models (GEMMs) have undergone significant evolution since their initial development in the late 1980s. Over the past decade, advancements in genome editing technologies such as clustered regularly interspaced short palindromic repeats (CRISPR)-Cas9, base editing, and prime editing, have sparked a new wave of innovation in the design and application of GEMMs. This article explores the historical development of GEMMs, recent technical advancements beyond CRISPR, their broad-spectrum applications across diseases, including autoimmune and cardiovascular, integration of multiomics approaches, and the role of GEMMs in pharmacokinetic and pharmacodynamicstudies. It also addresses aspects of colony management, experimental animal ethics, international regulations, convergence with artificial intelligence, and case studies of successful clinical translation based on studies using GEMMs. By synthesizing the latest literature from various international databases, this article provides a strategic guide for researchers to optimize the potential of GEMMs in improving the accuracy and translational relevance of innovative therapy development.

Page 1 of 1 | Total Record : 6

 1 

Filter by Year

2025 2025


Reset
Filter By Issues
All Issue Vol. 38 No. 12 (2025): MEDICINUS Vol. 38 No. 11 (2025): MEDICINUS Vol. 38 No. 10 (2025): MEDICINUS Vol. 38 No. 9 (2025): MEDICINUS Vol. 38 No. 8 (2025): MEDICINUS Vol. 38 No. 7 (2025): MEDICINUS Vol. 38 No. 6 (2025): MEDICINUS Vol. 38 No. 5 (2025): MEDICINUS Vol. 38 No. 4 (2025): MEDICINUS Vol. 38 No. 3 (2025): MEDICINUS Vol. 38 No. 2 (2025): MEDICINUS Vol. 38 No. 1 (2025): MEDICINUS Vol. 37 No. 3 (2024): MEDICINUS Vol. 37 No. 2 (2024): MEDICINUS Vol. 37 No. 1 (2024): MEDICINUS Vol. 36 No. 3 (2023): MEDICINUS Vol. 36 No. 2 (2023): MEDICINUS Vol. 36 No. 1 (2023): MEDICINUS Vol. 35 No. 3 (2022): MEDICINUS Vol. 35 No. 2 (2022): MEDICINUS Vol. 35 No. 1 (2022): MEDICINUS Vol. 34 No. 3 (2021): MEDICINUS Vol. 34 No. 2 (2021): MEDICINUS Vol. 34 No. 1 (2021): MEDICINUS Vol 34 No 1 (2021): MEDICINUS Vol. 33 No. 3 (2020): MEDICINUS Vol. 33 No. 2 (2020): MEDICINUS Vol. 33 No. 1 (2020): MEDICINUS More Issue