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Ratna Kumalasari
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INDONESIA
MEDICINUS
Published by PT Dexa Medica
ISSN : 1979391X     EISSN : 29638399     DOI : 10.56951
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health
Tujuan penerbitan jurnal Medicinus adalah untuk meningkatkan wawasan dan menambah khasanah pengetahuan para praktisi medis dan farmasis di bidang kedokteran dan kefarmasian. Ruang lingkup dari jurnal ilmiah ini adalah publikasi artikel-artikel ilmiah yang bisa disajikan dalam bentuk penelitian (research), laporan kasus (case report), teknologi dan klinis kefarmasian, serta ulasan literatur medis.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 6 Documents
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Search results for , issue "Vol. 38 No. 9 (2025): MEDICINUS" : 6 Documents clear
Analisis Drug Related Problems (DRPs) Potensial Pada Pasien Geriatri Penderita Osteoporosis di Salah Satu Rumah Sakit Kota Bandung Yared Yehuda
MEDICINUS Vol. 38 No. 9 (2025): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56951/h8v8c036

Abstract

Osteoporosis is a skeletal disorder characterized by decreased bone density, which predisposes individuals to an increased risk of fractures of the bones. The prevalence of osteoporosis is quite high among the geriatric patient population. Age-related complex medical problems are common in elderly, making them prone to drug-related problems (DRPs) that can affect therapeutic outcomes. This study aimed to identify and assess the incidence of potential DRPs in geriatric patients with osteoporosis, with or without comorbid condition. A cross-sectional, retrospective study was conducted using secondary data from medical records from January 2018 to December 2020. The sampling method used was purposive sampling, with a total sample of 100 geriatric patients. Inclusion criteria were patients aged >60years, outpatients, diagnosed with osteoporosis with or without comorbid conditions. Exclusion criteria were patients with incomplete or illegible medical record. Classification of DRPs was based on Pharmaceutical Care Network Europe (PCNE) version 9.1. The results showed that there were: drug interaction (43 cases, 39.09%), polypharmacy (29 cases, 26.36%), subtherapeutic doses (9 cases, 8.18%), less frequent drug administration (9 cases, 8.18%), untreated indication (6 cases, 5.45%), drug selection not within guidelines (5 cases, 4.55%), treatment duration too short (5 cases, 4.55%),drug administration without indication (3 cases, 2.73%), and drug duplication (1 case, 0.91%). Total incidence of DRPs was 58%. The most common drug for DRPs is calcium (48,30 %). A multivariate analysis using logistic regression showsthat the number of drugs could significantly affect the incidence of DRPs in patients (p<0.05) by 10.63 times.
Critical Care of Eclampsia with Partial HELLP Syndrome in Resource-Limited Setting: A Case Report Rizqhan, Muhammad; Wiedjaja, Aryasena Andhika
MEDICINUS Vol. 38 No. 9 (2025): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56951/3d3d3g27

Abstract

Background: Eclampsia is a hypertensive disorder of pregnancy characterized by life-threatening seizures and often requires intensive care among obstetric patients. HELLP (hemolysis, elevated liver enzymes, low platelets) syndrome is a complication of hypertensive disorders in pregnancy, marked by hemolysis, elevated liver enzymes, and thrombocytopenia. Developing countries have high maternal mortality rates due to inadequate antenatal maternal care services.Case Report: Mrs. D, 25 years old, married, a housewife, was referred to the emergency unit of Encik Mariyam Regional Hospital, Lingga, with seizures and decreased consciousness for the past 3 hours prior to admission. The patient wasdiagnosed with eclampsia complicated by partial HELLP syndrome and was scheduled for an emergency cesarean section (SC) by the obstetrician. General anesthesia was administered, and the patient received care in the intensive care unit (ICU) for 5 days under resource-limited conditions.Conclusions: Maternal mortality due to eclampsia and HELLP syndrome accounts for a significant proportion, especially in developing countries. Early diagnosis and prompt treatment by the ICU team can prevent complications and reduce morbidity and mortality. Emerging complications require early multidisciplinary intervention and treatment, including ventilator support, intensive monitoring, and the use of vasoactive medications, all of which can mitigate the progression of organ dysfunction and improve prognosis.
The Multifaceted Nature of Clopidogrel Resistance: Integrating Pharmacodynamic, Pharmacokinetic, and Pharmacogenomic  Andika Yusuf Ramadhan
MEDICINUS Vol. 38 No. 9 (2025): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56951/pex51w69

Abstract

Clopidogrel is a second-generation thienopyridine drug that acts as a platelet aggregation agent and widely used to treat cardiovascular disease by preventing the formation of thrombus.  Growing studies in the cardiovascular field have led to a new term, which is clopidogrel resistance. The mechanism of clopidogrel resistance could be the consequence of several factors such as decreased bioavailability due to pharmacokinetic changes, PK/PD interactions with other drugs, and genetic polymorphisms. Genetic polymorphisms affect the metabolism of clopidogrel prodrug, leading to sub-therapeutic concentrations of active metabolites. In addition, mutations in the P2Y12 receptor gene also impact platelet activity against agonis and antagonist ADP.  Measurement of platelet activity and pharmacogenomics profiling could help in diagnosing and monitoring clopidogrel therapy with suspicion of clopidogrel resistance.
Peran Krusial Farmakovigilans dalam Meningkatkan Keamanan Pasien (Patient Safety) Ana Widyaningsih
MEDICINUS Vol. 38 No. 9 (2025): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56951/zrh11y34

Abstract

Pharmacovigilance is the science and activities related to the detection, assessment, understanding, and prevention of adverse drug effects or other drug-related problems. The importance of drug safety monitoring stemmed from the thalidomide tragedy, which led to the formation of international programs to strengthen the regulatory framework on drug safety. Drug safety evaluation is conducted through a series of testing stages before a drug is marketed. However, pharmacovigilance activities performed post-marketing are crucial for detecting rare side effects that could not be identified during the pre-marketing testing phases. Multisectoral collaboration among various relevant parties and stakeholders is vital for the success of pharmacovigilance, with the ultimate goal of ensuring the safe use of medicines and patient safety.
Farmakogenomik dalam Pengobatan Presisi: Tinjauan dengan Studi Kasus Clopidogrel dan Tren Masa Depan Raymond R. Tjandrawinata
MEDICINUS Vol. 38 No. 9 (2025): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56951/fqx9vg55

Abstract

Pharmacogenomics has emerged as a cornerstone in the development of precision medicine, aiming to tailor drug therapy based on an individual’s genetic profile. By identifying genetic variations that influence drug metabolism, efficacy,and safety, pharmacogenomics paves the way for improved therapeutic outcomes reduced adverse drug reactions. One of the most significant examples in clinical practice is clopidogrel, an antiplatelet agent whose biopharmacologicalactivation depends on the CYP2C19 enzyme. Genetic variations in CYP2C19 significantly affect the clinical effectiveness of clopidogrel and the risk of major cardiovascular events. This article outlines recent developments in the implementationof pharmacogenomics, focusing on the clopidogrel case study, while also exploring other key gene–drug interactions such as codeine/CYP2D6, warfarin/VKORC1, and statin/SLCO1B1. The review also maps future trends in pharmacogenomics,including multiomic integration, preemptive genotyping, AI-based predictive modeling, and the potential for gene-editing interventions such as clustered regularly interspaced short palindromic repeats (CRISPR). Despite significant progress,implementation challenges remain, ranging from cost and healthcare infrastructure to ethical and regulatory dilemmas. This review aims to provide both a conceptual and practical foundation for the development of truly personalized pharmacotherapy in the future.
Dasar Neurobiologis Akuisisi Bahasa Dini: Mengapa Anak masih Mengungguli Kecerdasan Buatan Raymond R. Tjandrawinata
MEDICINUS Vol. 38 No. 9 (2025): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56951/qk5jw768

Abstract

Despite remarkable advances in artificial intelligence that have produced large language models (LLMs) capable of mimicking human linguistic behavior with high levels of sophistication, these systems still fall significantly short of the abilities of children in acquiring language rapidly, flexibly, and contextually. This article presents a systematic review from the perspective of cognitive and developmental neuroscience to address the question of why children remain superior in language learning compared to artificial intelligence systems. By examining mechanisms such as neuroplasticity, the involvement of social affective circuits, reward prediction systems, and multimodal sensorimotor functions in child language development, the article argues that human language acquisition is a phenomenon deeply embedded in the body, social relationships, and biological drives-dimensions that artificial systems inherently lack. The implications of this review extend to clinical interventions, education, and the development of AI systems that more closely approximate human neurocognitive architecture.

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