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Ramadhanti Salma Ulwanda
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Acta Neurologica Indonesia
Published by Universitas Indonesia
ISSN : -     EISSN : 30326303     DOI : https://doi.org/10.69868/ani.v2i02
Core Subject : Health, Science,
Medicine & Pharmacology Neuroscience Public Health
Acta Neurologica Indonesia is the official publication of the Department of Neurology, Faculty of Medicine, Universitas Indonesia under Directorate of Administration, Data, and Product Management of Research and Innovation Universitas Indonesia. This journal is published in trimonthly cycle with e-ISSN: 3032-6303. The Journal aims for continuous dissemination of updates in relation to neurology and its related fields in the form of original articles, case reports and reviews.
Arjuna Subject : Kedokteran - Neurologi Klinis
Articles 6 Documents
 1 
Search results for , issue "Vol. 2 No. 01 (2024): Acta Neurologica Indonesia" : 6 Documents clear
Role of Visual Evoked Potential in Direct Traumatic Optic Neuropathy: A Case Report : VEP in Direct TON Vania, Aurelia; Arimbawa, I Komang; Pratiwi, Ni Made Dwita
Acta Neurologica Indonesia Vol. 2 No. 01 (2024): Acta Neurologica Indonesia
Publisher : Departemen Neurologi Fakultas Kedokteran Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69868/ani.v2i01.16

Abstract

Traumatic optic neuropathy (TON) is a rare cause of visual impairment following blunt or sharp trauma and the diagnosis is established clinically. Lesions on the optic nerve may not always be visible in neuroimaging examinations. Studies on Visual Evoked Potential (VEP) in TON patients are still limited, despite being beneficial for objectively detecting optic nerve lesions. A 16-year-old male patient was referred to the neurology clinic with a sudden loss of vision in the left eye approximately 25 days after a head injury due to a motor vehicle accident. The patient had epidural bleeding and fractures in the orbital and facial bones, as revealed by a head CT scan. Neurological examination showed a visual acuity of 1/300 in the left eye, left midriasis, and a negative light reflex in the left eye. VEP examination of the left eye revealed prolonged P100 latency and a decrease in P100 amplitude (>50%), indicating a lesion in the left optic nerve. This visual impairment persisted for up to 6 months post-head trauma. TON is a vision-threatening disorder that should be considered in patients with ocular or head trauma and visual impairment. A decrease in amplitude ratio <50% and prolonged P100 latency >140 ms are associated with poor visual function recovery. VEP examination is an objective assessment of visual pathway integrity and serves as one modality for early TON diagnosis and a predictor of visual function prognosis in TON patients.   Keywords: diagnostic; prognostic; traumatic optic neuropathy; visual evoked potential
Association Between Brain Atrophy with EDSS and Number of Lesion Sites in Indonesian Multiple Sclerosis Patients Estiasari, Riwanti; Firdausia, Salsabila; Mulyadi, Rahmad; Yunus, Reyhan Eddy; Maharani, Kartika; Imran, Darma
Acta Neurologica Indonesia Vol. 2 No. 01 (2024): Acta Neurologica Indonesia
Publisher : Departemen Neurologi Fakultas Kedokteran Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69868/ani.v2i01.17

Abstract

Introduction : Multiple sclerosis (MS) is a potentially disabling inflammatory demyelination of the central nervous system. The demyelination process will end up with the destruction of neurons that leads to the decrease of brain volume. Brain atrophy may cause more severe disability and affect the quality of life of MS patients, who are mostly at a young age. Objective : Our study aims to assess the brain atrophy among Indonesian MS patients and the association between with the degree of disability. Material and methods : A cross-sectional study included 28 MS patients. To determine the brain atrophy, we compared 11 healthy control group to the MS group. Head MRI was performed using 1.5T MRI and the brain volume was processed with Freesurfer type 6.0 automatic software. Result : The white matter (WM) and gray matter (GM) volume of MS patients was significantly lower compared to normal control with 78.6% GM atrophy and 67.9% WM atrophy. EDSS score is significantly associated with WM atrophy but not with GM atrophy. Factors related to WM atrophy is age, age of onset, and subtype of MS. A number of lesion sites were found greater in subjects with GM and WM atrophy. Discussion : The mechanisms of brain atrophy in MS involve inflammatory processes and neurodegeneration. Various factors, including lesion volume impact atrophy rates. Brain atrophy had correlation with EDSS scores. Conclusion : Brain atrophy was common in MS patients and significantly associated with the level of disability and number of lesion sites.
Case Series: Risk and Clinical Manifestation of Non-Convulsive Status Epilepticus After Traumatic Brain Injury Ramli, Yetty
Acta Neurologica Indonesia Vol. 2 No. 01 (2024): Acta Neurologica Indonesia
Publisher : Departemen Neurologi Fakultas Kedokteran Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69868/ani.v2i01.20

Abstract

Traumatic brain injury occurs due to impacts on the head or penetrating injuries that result in damage to the brain. Traumatic brain injury can lead to complications, including post-traumatic seizures. Seizures following traumatic brain injury (TBI) present a complex interplay of various risk factors and determinants that significantly impact clinical outcomes and patient management, especially in non-convulsive status epilepticus. Non-convulsive status epilepticus (NCSE) is an underrecognized complication following traumatic brain injury (TBI), with potentially severe consequences for patient outcomes. Factors contributing to NCSE development include level of consciousness, injury severity, and cortical involvement. Clinical presentation is often subtle, ranging from altered mental status to focal neurological deficits. Early recognition through EEG monitoring is crucial, guiding targeted antiepileptic therapy to mitigate neuronal injury and improve outcomes Understanding these risk factors and clinical manifestations are crucial for effective surveillance, early intervention, and tailored treatment strategies aimed at mitigating the burden of seizures and improving the long-term prognosis of individuals with TBI.
Marital Status As A Predictor of Amnestic Mild Cognitive Impairment in Indonesia Chandra, Fani Agusta; Darmawan, Octavianus
Acta Neurologica Indonesia Vol. 2 No. 01 (2024): Acta Neurologica Indonesia
Publisher : Departemen Neurologi Fakultas Kedokteran Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69868/ani.v2i01.22

Abstract

Introduction: Several modifiable risk factors have been identified as the predictors of amnestic mild cognitive impairment (aMCI). However, research focusing on factors beyond biological is limited. Marital status is a psychosocial factor with recognized impact on health that needs further exploration. Objective: This study aimed to evaluate the association between marital status and aMCI amongst older Indonesian population. Material and methods: This was a cross-sectional study of Indonesian Family Life Survey-5. The participants (≥60 years old), excluding individuals with functional dependency, were subdivided into two based on word list recall (WLR) score (cut-off<6.5). Sociodemographic, psychological factors, physical activity, and body mass index were included as predictors. Bivariate and multivariate analyses were conducted. Result: A total of 4287 participants were included. Significant associations were observed between low WLR score and older age, low education, low socioeconomic status, rural residential area, being unmarried, life dissatisfaction, no social engagement, negative affect, and obesity. Multivariate analysis revealed being unmarried was significantly associated with aMCI (AOR 2.38, 95% CI 1.014–5.589, p=0.046), along with older age, low education, low socioeconomic status, and obesity. Discussion: Being unmarried (never married, divorced, or widowed) is a significant predictor of aMCI amongst Indonesian older people. This finding can be explained by the marital resource model and the stress model. Conclusion: This nationwide study is one of the first to explore marital status as a potential yet underexplored factor of aMCI in Indonesia. Being unmarried is associated with an increased risk of aMCI, prompting different approaches in this population.
Quantitative EEG Findings in Post-Stroke Epilepsy Patients Ramli, Yetty
Acta Neurologica Indonesia Vol. 2 No. 01 (2024): Acta Neurologica Indonesia
Publisher : Departemen Neurologi Fakultas Kedokteran Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69868/ani.v2i01.23

Abstract

Post-stroke epilepsy presents a significant clinical challenge, often accompanied by cognitive impairments. The qEEG analysis in this case reveals notable abnormalities, including increased delta waves and decreased high-frequency activity, localized to specific brain regions. These findings not only strengthen diagnostic assessments but also provide valuable insights into the underlying pathophysiology of post-stroke epilepsy. Moreover, they serve as a basis for selecting personalized therapeutic interventions, such as neurofeedback therapy. By tailoring treatment to the captured brainwave frequencies during recording, non-invasive therapeutic options can be explored as viable alternatives for patients. Integrating qEEG findings into clinical practice enhances our understanding of post-stroke epilepsy's complex nature and guides optimal patient care and management strategies.
Depression Level Among Neurology Resident Doctors in the Faculty of Medicine, Universitas Indonesia Dyah Perwitasari, Vina; Hidayat, Rakhmad
Acta Neurologica Indonesia Vol. 2 No. 01 (2024): Acta Neurologica Indonesia
Publisher : Departemen Neurologi Fakultas Kedokteran Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69868/ani.v2i01.25

Abstract

Introduction: A resident doctor is a doctor who has graduated from medical school, has earned the title of "doctor" and is currently undergoing a specific specialization postgraduate program. Resident doctors are at high risk of experiencing stress and depression. Depression greatly affects the quality of medical services provided by residents. Objective: This study aimed to determine the prevalence of depression, its relationship with various sociodemographic factors and several environmental factors, and its relation to the residency level of resident doctors in the Neurology Study Program, Faculty of Medicine, Universitas Indonesia. Material and Methods: This research was an analytic observational study with a cross-sectional design. All neurology resident doctors of Universitas Indonesia had filling out a questionnaire containing sociodemographic data and the Beck Depression Inventory-II (BDI-II) via Google Form platform. Then, the data were analyzed using chi-square and regression analysis. Result: In this study, 53 (66.2%) participants were females and 16 (33.8%) were males. Sixty-five participants were analyzed with 4 participants excluded. The overall prevalence of depression was 18.2%, with mild depression at 9.2% and moderate depression at 9.2%. Depression was more common in females than males (10.8% vs 7.7%). The residency level and supervisor support have a significant association with the incidence of depression. Conclusion: Our study found that 18.4% of neurology resident doctors had depression. Residency level and senior/supervisor support were significantly associated with depression among resident doctors.

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