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Prasetyadi Mawardi
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Bagian Pendidikan & Penelitian RSUD Dr. Moewardi Jl. Kol. Soetarto 132 Fax (0271) 666954 Surakarta
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INDONESIA
Indonesian Basic and Experimental Health Sciences
Published by RSUD Dr. Moewardi
ISSN : -     EISSN : 30255929     DOI : 10.11594/ibehs
Core Subject : Health,
Health Professions Medicine & Pharmacology Nursing Public Health
Indonesian Basic and Experimental Health Sciences Journal (IBEHS) is a health journal published by RSUD Dr. Moewardi Surakarta, Central Java, Indonesia as a contribution to RSUD Dr. Moewardi for the development and progress of health science which is marked by various innovations and creativity of health workers, both in the Dr. Moewardi or other health workers who are always concerned about education, research, and community service in the health sector.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 5 Documents
 1 
Search results for , issue "Vol. 14 No. 2 (2026): April" : 5 Documents clear
The Effectiveness of Topical Insulin for Ulcer Healing: A Pilot Study: A Pilot Study Nareswari, Adniana; Rosmarwati, Ervina; Wijayawati, Merlina; Oktiningrum, Hastika Dwi; Yasmin, Aulia
Indonesian Basic and Experimental Health Sciences Vol. 14 No. 2 (2026): April
Publisher : Rumah Sakit Umum Daerah Dr. Moewardi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/ibehs.vol14iss2pp123-127

Abstract

Introduction Chronic ulcers continue to pose a major clinical challenge, contributing to significant morbidity and mortality. These conditions are frequently associated with diabetes, venous disorders, neuropathy, and other systemic illnesses. Conventional treatments often yield suboptimal results, encouraging investigation into alternative approaches such as topical insulin. This study aims to evaluate the effectiveness and safety of topical insulin in promoting ulcer healing. Method A pre-post interventional pilot study was conducted at Dr. Moewardi General Hospital from September to October 2024. Seven patients aged 40-80 years with grade II-III ulcers were treated with a topical insulin solution (10 IU insulin in 1 mL saline), applied once daily for 14 days. Ulcer size was measured on days 0, 7, and 14. Adverse effects were also monitored. Result Out of seven participants, three showed significant improvement in ulcer size (75-100% reduction), three showed mild to moderate improvement (8-26%), and one had no response. No local or systemic adverse events, including hypoglycemia, were observed. Factors such as limited patient mobility affected follow-up adherence. Discussion The findings suggest topical insulin enhances ulcer healing through mechanisms involving cell proliferation, angiogenesis, and anti-inflammatory effects, consistent with prior studies. However, the small sample size and loss to follow-up limit generalizability. Further trials are required to confirm its clinical utility. Conclusion Topical insulin appears to be a safe and potentially effective adjunct therapy for ulcer healing in both diabetic and non-diabetic patients. Larger-scale studies with control comparisons are needed to confirm its efficacy and optimize treatment protocols.
Henoch–Schönlein Purpura with Gastrointestinal Involvement in an Adult Patient: A Case Report Lamsir, Seno; Yustin Ellistasari, Endra; Rosmarwati, Ervina; Mawardi, Prasetyadi
Indonesian Basic and Experimental Health Sciences Vol. 14 No. 2 (2026): April
Publisher : Rumah Sakit Umum Daerah Dr. Moewardi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/ibehs.vol14iss2pp111-115

Abstract

Introduction Henoch–Schönlein purpura (HSP), also known as IgA vasculitis, is a systemic small-vessel vasculitis characterized by IgA immune complex deposition. Although predominantly a childhood disease with a generally favorable prognosis, adult cases often exhibit more severe systemic involvement, particularly affecting the gastrointestinal tract and kidneys. Case A 22-year-old female presented with palpable purpura on the extremities, arthralgia, and melena. Physical examination revealed confluent purpuric lesions over the arms and legs. Endoscopy revealed esophagitis and antral gastritis. Skin biopsy demonstrated flattening of rete ridges and perivascular infiltrates, consistent with leukocytoclastic vasculitis. The patient was treated with intravenous methylprednisolone and supportive therapy, resulting in significant improvement of skin lesions, joint pain, and resolution of gastrointestinal bleeding. Discussion Adult HSP is less common but typically has a more severe course compared to pediatric cases. Gastrointestinal involvement, as seen in this case, may present as bleeding, ischemia, or ulceration, and can be life-threatening. Corticosteroids are effective in controlling inflammation and alleviating symptoms but do not prevent renal complications. Continuous renal monitoring is crucial, as kidney involvement remains the primary determinant of long-term prognosis. Conclusion This case highlights the clinical relevance of HSP in adults, where gastrointestinal manifestations may predominate and require aggressive management. Long-term follow-up, especially for renal involvement, is essential to improve outcomes.
Nail Abnormalities In Genodermatose Widhiati, Suci; Danarti, Retno; Budi Rustiawati, Cyntia Arum
Indonesian Basic and Experimental Health Sciences Vol. 14 No. 2 (2026): April
Publisher : Rumah Sakit Umum Daerah Dr. Moewardi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/ibehs.vol14iss2pp128-134

Abstract

Introduction Nail abnormalities may serve as early indicators of various genodermatoses, either presenting in isolation or alongside systemic features. These abnormalities, though sometimes cosmetic, often hold significant diagnostic value, especially in inherited ectodermal disorders. Understanding the anatomy and embryology of the nail unit is crucial for identifying the origin and nature of such defects. Method This literature review was conducted by analyzing selected journal articles, case reports, and textbooks focusing on genodermatoses with distinct nail involvement. The analysis centered on the classification of nail abnormalities based on their anatomical origin: nail matrix, nail bed, or combined mesodermal-ectodermal defects. Results Findings revealed that nail abnormalities are prominent in several genodermatoses. Nail matrix defects are observed in congenital dyskeratosis, marked by nail dystrophy, leukoplakia, and mucocutaneous pigmentation. Nail bed defects, as seen in congenital pachyonychia and hydrotic ectodermal dysplasia, lead to thickened, dystrophic nails and associated skin changes. Combined mesodermal-ectodermal disorders, such as nail-patella syndrome, present with absent or hypoplastic nails alongside skeletal, renal, and ocular abnormalities. Each condition displayed specific nail manifestations that can aid early diagnosis. Discussion: The review emphasizes the importance of integrating knowledge of nail anatomy and development to differentiate between types of nail abnormalities. Identifying the anatomical origin aids in narrowing the differential diagnosis and can provide early clues to systemic genodermatoses, even before other clinical signs emerge. Conclusion: Nail abnormalities are important diagnostic markers in genodermatoses. Routine nail examination should be an integral part of dermatological assessments to facilitate early recognition and diagnosis of underlying genetic disorders.
Survival is Just the Beginning: Quality of Life in Patients (QoL) with Intraoral and Extraoral Squamous Cell Carcinoma (SCC) Mustawan, Mohamad Rifki Adli; Soewoto, Widyanti
Indonesian Basic and Experimental Health Sciences Vol. 14 No. 2 (2026): April
Publisher : Rumah Sakit Umum Daerah Dr. Moewardi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/ibehs.vol14iss2pp116-122

Abstract

Introduction Squamous cell carcinoma (SCC) continues to be a health problem worldwide with far reaching effects not only on survival but on patient's quality of life (QoL). Health-related quality of life (HRQoL) assessment sheds lights on overall disease and its treatment impact. Method In this cross-sectional study was performed on 53 patients diagnosed with SCC, which included 36 intraoral and 17 extraoral cases. Sociodemographic data was collected and the QoL was assessed by using the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ-C30) and short form-36 (SF-36). The data were analyzed using Mann-Whitney U test and Spearman’s correlation. Results Among 53 SCC patients (36 intraoral, 17 extraoral; mainly middle-aged females of low socioeconomic status), overall Quality of Life (QoL) score did not differ between groups. In summary, the analyses revealed additional differences in QoL determinants as patients with intraoral head and neck Squamous cell carcinoma (SCC) QoL was driven towards functional domains whereas symptom-related determinants were dominated for extraoral SCC patients. There was no statistically significant difference in overall QoL (p = 0.839) between groups. Discussion This study provides evidence suggesting that QoL impairments associated with intraoral SCC and with extraoral SCC are primarily driven by symptom burden and pain, and that there is no difference between the groups in overall quality of life (QoL). The relationship between QoL and functional limitations was more pronounced for intraoral SCC, whereas symptom severity had a greater impact on mental status for extraoral SCC. These results are consistent with existing evidence that SCC affects multiple dimensions of health irrespective across the sites of the tumor. There are QoL data available for management of various chronic conditions, and they highlight the importance of more comprehensive, patient-centred care that emphasizes early symptom control along with optimal pain management and functional rehabilitation strategies. Conclusion Demographics do not affect the quality of life of SCC patients, as clinical variables like symptoms, pain, and limitations impact it more than demographic data. Patients with intraoral SCC also experienced moderate QoL, highlighting opportunities for better symptom control and psychosocial support to improve overall patient health-related QoL.
The Effect Of Proctor Supervision Model On Nurses' Compliance Level In Performing Wound Care According To SOP (Standard Operating Procedure) In Flamboyan 5 Surgical Inpatient Ward At Dr. Moewardi Regional General Hospital Tri Mulyanto, Warih; Ardian Oktavia, Faisal; Balighoh, Farhatul; Fatiha, Chalista Ayu
Indonesian Basic and Experimental Health Sciences Vol. 14 No. 2 (2026): April
Publisher : Rumah Sakit Umum Daerah Dr. Moewardi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/ibehs.vol14iss2pp103-110

Abstract

Introduction Nurse compliance with wound care procedures remains a challenge in ensuring patient safety, particularly in surgical wards that require precision in clinical practice (Kamil & Wardhani, 2020; Wang & Lee, 2020). Inconsistent adherence to standard operating procedures (SOPs) may increase the risk of infection and affect the quality of nursing services. Therefore, effective supervision is required to improve compliance in clinical practice. Objective This study aimed to analyze the effect of the Proctor supervision model on nurses’ compliance in performing wound care according to standard operating procedures in the Flamboyan 5 Surgical Inpatient Ward at Dr. Moewardi Regional General Hospital. Method This study used a quasi-experimental design with a pre-test and post-test approach without a control group. A total of 19 nurses were selected using the total sampling technique. Data were collected using a Guttman scale observation sheet consisting of 26 wound care procedure indicators. Data were analyzed using univariate and bivariate methods. Because the data were not normally distributed, the Wilcoxon Signed Rank Test was used to examine differences in compliance scores before and after the intervention. Results Before supervision, all respondents (100%) were categorized as partially compliant. After the Proctor supervision intervention, seven nurses (36.8%) were categorized as compliant, while twelve nurses (63.2%) remained partially compliant. Statistical analysis showed a significant difference between pre- and post-intervention compliance scores (p < 0.05). Conclusion The Proctor supervision model can be considered a useful strategy to improve nurse compliance in wound care practice and to support patient safety and nursing care quality.

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