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Annales Bogorienses
Published by Badan Riset dan Inovasi Nasional
ISSN : 05178452     EISSN : 24077518     DOI : https://doi.org/10.55981/ann.bogor
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Annales Bogorienses aims to disseminate high-quality scientific research in the field of life sciences, with a strong emphasis on advancing knowledge and applications in biotechnology, molecular biology, biochemistry, bioinformatics, and bioengineering. The journal serves as a platform for researchers, academicians, and practitioners to share original findings, innovative methodologies, and critical reviews that contribute to scientific progress and sustainable development. The journal covers research in biotechnology, molecular biology, biochemistry, bioinformatics, and bioengineering. It publishes original research articles, reviews, and short communications, and is committed to rigorous peer review and open access for the widest possible dissemination of scientific knowledge.
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Articles 6 Documents
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Search results for , issue "Vol. 25 No. 2 (2021): Annales Bogorienses" : 6 Documents clear
Front Pages Volume 25 No 2 (2021) Rahman, Andri
Annales Bogorienses Vol. 25 No. 2 (2021): Annales Bogorienses
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Mini Review: Prostate Cancer Diagnosis and Therapy Fathurahman, Alfi Taufik; Swasthikawati, Sri; Irawan, Herman; Supriatna, Dadang; Wardiana, Andri
Annales Bogorienses Vol. 25 No. 2 (2021): Annales Bogorienses
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Cancer, a non-communicable illness, is the leading cause of death worldwide. In 2030, cancer is expected to exceed 21 million cases and 13 million cancer deaths globally. One of the most prevalent and significant types is prostate cancer (PCa). It is commonly associated with adenocarcinoma, which develops from the mucous glands within the organ. This review highlights available detection systems, and therapeutic options in PCa management. One prevention of deadly PCa is early diagnoses, such as prostate-specific antigen (PSA) screening or genomic profiling. Further testing like MRI or CT scan may also be needed to detect cancers that have progressed to other body regions. There are several possible treatments for PCa, including watchful cancer waiting, surgery, radiotherapy, hormone therapy, and chemotherapy. Based on current studies, androgen deprivation therapy (ADT) combined with docetaxel therapy enhanced great results to treat advanced PCa. The latest development, called theranostics, is a single entity that can perform both diagnostic and therapeutic functions. It can detect disease borders, track therapy in real-time, and provide prognostic data. The FDA has already authorized two prostate-specific membrane antigen (PSMA) positron emission tomography (PET) devices: including Gallium 68 PSMA-11 (Ga 68 PSMA-11) and Pylarify (piflufolastat F 18).
Factors Affecting Expression Level of Recombinant Human Epidermal Growth Factor in Escherichia coli BL21(DE3) and Size Exclusion Purification Thereof Pratiwi, Riyona Desvy; Agustina, Nabella; Aminah, Aminah; Fuad, Asrul Muhamad
Annales Bogorienses Vol. 25 No. 2 (2021): Annales Bogorienses
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Recombinant human epidermal growth factor (rhEGF) has been developed to provide the protein for therapeutic uses. Isopropyl β-d-1-thiogalactopyranoside (IPTG)-induced expression in Escherichia coli BL21(DE3) has shown the most effective system among other inducers systems in a similar host. However, suitable conditions related to IPTG concentration, incubation time, and incubation temperature are different depending on the amino acid content of the recombinant protein. This study aimed to evaluate the effects of various IPTG concentration, incubation time, and incubation temperature on rhEGF concentration. According to each analysis of those factors, induction with 0.05 mM IPTG for 2 h at 23°C was the most appropriate condition to obtain the highest concentration of rhEGF. The rhEGF was positively confirmed with a monoclonal antihEGF antibody and purified in high purity reaching 95.2%, yet recovery was low (1.44%) due to loss in fractions containing endogenous proteins. Therefore, further studies related to type of matrix, column length, and sample concentration in applying size exclusion chromatography are requested for higher recovery
Screening of Active Compounds and LC50 Toxicity Assay of Sunda Porcupine’s (Hystrix javanica F. Cuvier 1823) Quills Crude Extract Budiman, Muhamad Arif; Ferdian, Pamungkas Rizki; Handayani, Tri Hadi; Nugroho, Herjuno Ari; Elfirta, Rizki Rabeca; Farida, Wartika Rosa
Annales Bogorienses Vol. 25 No. 2 (2021): Annales Bogorienses
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Sunda porcupine (Hystrix javanica F. Cuvier 1823) is an endemic fauna from Indonesia that its quills are believed to have medical benefits by local people in some regions of Indonesia. However, the benefits have never been well recorded nor proven scientifically. Local people believe the Sunda porcupine’s quills have efficacy to relieve property for treating toothache. There is limited research on Sunda porcupine’s quills, especially the active compounds, which may affect toothache. This research aims to perform basic pharmacological experiments on Sunda porcupine’s quill samples, which includes screening for the active compounds and determining the LC50 toxicity using brine shrimp lethality test (BSLT) method. Sunda porcupine’s quills were first prepared into simplicia powder (60 mesh in size) and then extracted with 70% ethanol by maceration to produce crude extract. We found that the crude extract of Sunda porcupine’s quills contains some active compounds, including alkaloids, flavonoids, saponins, triterpenoids, steroids, and peptides. The LC50 value of the crude extract was 2,683.19 ppm; thus, categorized as non-toxic. These findings can be used to identify the active compounds in Sunda porcupine’s quills and can be used as a background for further research.
Antioxidant, Antibacterial, and Antidiabetic Activities of Roselle (Hibiscus sabdariffa) Extracts Suharli, Lili; Manguntungi, Baso; Azis, Andi Asmawati; Mustopa, Apon Zaenal; Meilina, Lita; Pandayu, Iga Firmansyah; Vanggy, Leggina Rezzy; Irawan, Shasmita
Annales Bogorienses Vol. 25 No. 2 (2021): Annales Bogorienses
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Hibiscus sabdariffa L., also referred to as roselle, is commonly utilized in the pharmaceutical and food industries. Roselle contains bioactive compounds such as phenolics, alkaloids, tannins, flavonoids, saponins, and organic acids, which have pharmacological properties, such as antioxidant, antibacterial, immune booster, antidiabetic, anti-inflammatory, and anti-hypertensive properties. There are many studies regarding the pharmacological activities of roselle extract and its applications. However, there has been no research to study the effectiveness of the solvent in testing roselle petal extracts against antibacterial, antioxidant, and antidiabetic activities, simultaneously. This research used two kinds of polar solvents, dH2O and ethanol, with various concentrations for antibacterial activity test by five pathogenic bacteria, for antioxidant test by the DPPH method, and for antidiabetic test by the alpha-glucosidase inhibition method. The result showed that the ethanol extract of roselle had higher antibacterial activity compare to the roselle water extract. Antioxidant activity of roselle ethanol extract at 20% concentration had the highest activity 69.75 ± 0.002%; while, the 100% concentration of roselle water extract had the highest antioxidant activity 138.73 ± 0.013%. antidiabetic activity of roselle ethanol and water extract at 100% concentration had the highest activity 1,195.44 ± 0.007% and 1,552.49 ± 0.069%, respectively.
Isolation and Characterization of Bacterial Carbonate Precipitation for Biogrouting Suyanto, Eko; Sari, Miranti Nurindah; Ratnakomala, Shanti; Fahrurrozi, Fahrurrozi; Gusmawati, Niken F.
Annales Bogorienses Vol. 25 No. 2 (2021): Annales Bogorienses
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Biogrouting is a process that transforms soil or sand into calcarenite or sandstone by bacterial calcium carbonate precipitation . The mechanisms of this process are that the bacteria hydrolyze urea catalyzed by urease, and with the existence of dissolved Ca2+, a solid crystalline calcite or calcium carbonate (CaCO3) will be produced. The main advantage of biogrout is that soil or sand can be strengthened without interfering with the hydraulics of the treated soil or sand and without excavation or replacement. In this study, the isolation and identification of bacterial calcium carbonate precipitation , and characterization of urease produced by bacteria were conducted. In the isolation method, the enrichment method using urea as abacterial carbon source was carried out. The formation of crystalline calcite was observed by a light microscope. The urease enzyme activity was determined by the 3, 5-Dinitrosalicylic acid (DNS) method. The molecular identification of isolates was analyzed by the determination of 16S rRNA gene sequencing. As a result, 19 calcium carbonate precipitation have been isolated from soils, sands, water, and rocks collected from several areas in Indonesia. They showed calcite formation in a medium with urea. Molecular identification of isolates with high urease enzyme activity revealed that the isolates belong to the group Bacilli. The highest enzyme activity produced by ID10-U004 is 374.94 U/mL. The preliminary biogrouting experiment was also conducted using isolated strain, and the reaction was able to make the sand solid and stiff.

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