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JURNAL TEKNOLOGI, KESEHATAN DAN ILMU SOSIAL
ISSN : 22708907     EISSN : 22708907     DOI : https://doi.org/10.51544/tekesnos.v7i1
Focus: Jurnal Teknologi Kesehatan dan Ilmu Sosial (TEKESNOS) diterbitkan oleh Program Studi Sistem Informasi Fakultas Sain dan Teknologi Informasi, Ilmu Kesehatan Fakultas Farmasi dan Ilmu Kesehatan serta Ilmu Sosial Fakultas Ilmu Pendidikan Universitas Sari Mutiara Indonesia di Medan sebagai media untuk menyalurkan hasil pemikiran yang mendasari teknologi menjadi hal penting di dalam segala keilmuan, baik dari segi kesehatan dan ilmu sosial. Jurnal TEKESNOS terbangun dari kolaborasi multidisiplin ilmu dalam menghasilkan penelitian dan pengabdian masyarakat pada bidang teknologi berbasis industri 4.0. Scope: Multidisplin ilmu bidang Teknologi, Kesehatan dan Sosial humaniora, ekonomi, kimia, dan displin ilmu lainnya berupa hasil penelitian.
Arjuna Subject : Umum - Umum
Articles 60 Documents
Search results for , issue "Vol. 4 No. 1 (2022): JURNAL TEKNOLOGI KESEHATAN DAN ILMU SOSIAL (TEKESNOS)" : 60 Documents clear
Aktivitas Penghambatan Enzim Protease 6lu7 Virus Sars-Cov-2 Oleh Senyawa Steroid Glikosida Dari Daun Afrika (Vernonia amygdalina Del.) Secara In Silico Mainal Furqon; Cut Masyithah Thaib; N Daely, Ruth Christiani
JURNAL TEKNOLOGI KESEHATAN DAN ILMU SOSIAL (TEKESNOS) Vol. 4 No. 1 (2022): JURNAL TEKNOLOGI KESEHATAN DAN ILMU SOSIAL (TEKESNOS)
Publisher : Universitas Sari Mutiara Indonesia

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Background: Vernonia amygdalina Del. Isaplant from the Asteraceae family is a small shrub with dark green leaves and leathery bark that grows predominantly in Africa. This plant contains steroidgly cosides, such: as Vernodalin, Vernolide, Vernolepin, Vernomenin, Vernomydin, Vernodalol, Hydroxylvernolide,11,13-dihydroxylvernodalin, 4,15-dihydrovernodalin, 1,2,3,15,11,13,2’,3’, hexahydrovernodalin, dan 1,2,3,15,11,13,2’,3’-octahydro vernodalin. Sesquiterpene Lakton in African leaves (Vernonia amygdalina) have properties, among others, as antimicrobials. Objective:  The purpose of this study was to determine the inhibition of the SARS-CoV-26LU7 protease enzyme by Sesquiterpen Lakton compounds from African leaves using the in-silico tethering method. Method: The in-silicomooring process is carried out using the PLANTS program and visualized using the MOE 2008 program. The protease enzyme was downloaded through the Protein Data Bank (PDB) with code 6LU7. Two-and three-dimensional models were generated using the Marvin Sketch program. The resulting docking value is evaluated as a result of the docking process. Results: The results showed that the protease 6LU7 enzyme tethering of the SARS-CoV-2 virus could provide valid results in-silico. The Sesquiterpen Lakton compounds from Afri can leaves can inhibit the protease enzyme. The docking result is a bletovisualize of the binding amino acids. Conclusion: In this study, it can be concluded that the Sesquiterpen Lakton compounds from African leaves can inhibit the SARS-CoV-2 virus 6LU7 protease enzyme with a docking score close to the docking score of each comparator drug.
Aktivitas Antibakteri Minyak Atsiri Buah Andaliman (Zanthoxylum acanthopodium DC) Terhadap Bakteri Streptococcus mutans dan Propionibacterium acne Fitri, Widya; Tarigan, Yenni Gustiani; Silitonga, Evawani Martalena; Telambenua, Fiki julfitra
JURNAL TEKNOLOGI KESEHATAN DAN ILMU SOSIAL (TEKESNOS) Vol. 4 No. 1 (2022): JURNAL TEKNOLOGI KESEHATAN DAN ILMU SOSIAL (TEKESNOS)
Publisher : Universitas Sari Mutiara Indonesia

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Andaliman fruit is a cultivation plant that functions as an antibacterial. Streptococcus mutans is a bacterium that causes dental caries which causes damage to hard tissues. Acne propionibacterium Is a bacterium that causes skin diseases that cause inflammation of tissues associated with immune systems and supports inflammation of acne. Clindamicin is a broad spectrum broad-spectrum bacteriostatic antibiotic that is active against aerobic and anaerobic microorganisms, positive and negative bacteria. Isolation of andaliman fruit essential oil using the air distillation method using a stahl tool. Antibacterial activity test using disc diffusion on MHA media by determining the diameter of the inhibition zone. The concentration of andaliman fruit essential oil used was 2.5%, 5%, 10%, 20% and 40%, with n-hexane p.a solvent and clindamicin concentration 30 μg / ml which was used as a comparison with aquadest solvent. The results showed the diameter of the combined inhibitory zones in Streptococcus mutans bacteria. With a concentration of 2.5% inhibition zone 8.8 mm, inhibition zone 5% 9.0 mm, 10% inhibition zone 10.1 mm, 10% inhibition zone 11.1 mm, 40% 14.5. In acne bacteria Propionibacterium. 2.5% inhibition zone 9.1 mm, 5% inhibition zone 9.2 mm, 10% inhibition zone 10.3 mm, 20% inhibition zone 12.6 mm, 40% 14.1. And clindamicin as a comparison has a 30.6 mm inhibitory zone in acne Propionibacterium bacteria and in Streptococcus mutans. 29.2 mm. From the results of the antibacterial activity test of andaliman essential oil at a concentration of 2.5%, 5%, 10%, 20% and 40%, able to inhibit the growth of Streptococcus mutans and Propionibacterium acne. The results of isolation of Andaliman fruit essential oil by using the Stahl tool are available 4.76% essential oil
Uji Aktivitas Antibakteri Ekstrak Etanol Daun Kemangi (Ocimum sanctum L) Sebagai Antibakteri Terhadap Streptococcus mutans Rialita Lifiani*; Rezza Fikrih Utama; Ester Saripati Haria; Rahayu Kartini
JURNAL TEKNOLOGI KESEHATAN DAN ILMU SOSIAL (TEKESNOS) Vol. 4 No. 1 (2022): JURNAL TEKNOLOGI KESEHATAN DAN ILMU SOSIAL (TEKESNOS)
Publisher : Universitas Sari Mutiara Indonesia

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Background: One of the traditional medicinal plants that are widely used by the Indonesian people is the basil plant (Ocimum sanctum L). Which has a role as an antibacterial that can inhibit the growth of bacteria. Objectives: The Purpose of this study was to determine the ability of basil leaf extract (Ocimum sanctum L) to inhibit the growth of Streptococcus mutans bacteria from concentrations of 20%, 40%, 60%, 80% and to determine the effective concentration of antibacterial activity against the growth of Streptococcus mutans bacteria. Method: This research method used the experimental method. Antibacterial activity was tested by diffusion method using disc paper. The ethanol extract of basil leaves was made by maceration method using 96% ethanol as solvent. The concentration of the test solution used was a negative control DMSO, positive control of Chlorhexidine. Result: The results of the phytochemical screening test of basil leaf powder showed the presence of Flavonoid compounds, Steroids/Triterpenoids, tannins, and saponins. The results of the antibacterial activity test showed that the basil leaf extract gave inhibition zones at concentrations of 20%, 40%, 60%, and 80% against Streptococcus mutans bacteria, each of which had an inhibition zone (13,5mm), (16,6mm), (18mm), and (18,9mm) in Chlorhexidine 20,6mm. Conclusion: The conclusion from research results can be concluded that basil leaf extract (Ocimum sanctum L) has anti-Bacterial activity against Streptococcus mutans bacteria.
Uji Aktivitas Antibakteri Ekstrak Etanol Kaktus Centong (Opuntia cochenillifera) Terhadap Pertumbuhan Bakteri Staphylacoccus epidermidis Dengan Media Buatan Pati Pisang Kepok (Musa paradisiaca) Manuppak Irianto Tampubolon; Natanael Priltius; Alfian Rejekinta Munthe
JURNAL TEKNOLOGI KESEHATAN DAN ILMU SOSIAL (TEKESNOS) Vol. 4 No. 1 (2022): JURNAL TEKNOLOGI KESEHATAN DAN ILMU SOSIAL (TEKESNOS)
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Centong Cactus (Opuntia cochenilifera) is one of the plants used to treat health problems, but this is done based on hereditary experience. This plant contains flavonoids, tannins, saponins, and steroids. The purpose of this study was to see the antibacterial activity of the ethanol extract of Centong cactus (Opuntia cochenillifera) using alternative media of Kepok banana starch and Muller Hilton Agar Media. This study was conducted experimentally. Samples were extracted by maceration method using 96% ethanol as solvent. Antibacterial activity was tested by disk diffusion method with paper backing technique. The parameters observed were zone of inhibition. Based on the result of the inhibition zone research, the best results were obtained on the banana starch media with a concentration of 40% 18,7mm and on Muller Hilton Agar media with a concentration of 40% 20,1mm. The antibacterial test result stated that the ethanolic extract of Centong cactus could provide an effective inhibition again Staphylococcus epidermidis bacteria. Antibacterial activity using Mullerr Hilton Agar media in order to have a larger zone of inhibition than using kapok banana starch.
Pembuatan Media Pertumbuhan Alternatif Pada Mikroorganisme Dengan Menggunakan Umbi Porang (Amorphophallus oncophyllus Prain) TERHADAP Staphylococcus aureus, Escherichia coli DAN Candida albicans Marpaung, Jon Kenedy; Purba, Sondang; Juniwati Barus, Darwita; Iqlima, Dara
JURNAL TEKNOLOGI KESEHATAN DAN ILMU SOSIAL (TEKESNOS) Vol. 4 No. 1 (2022): JURNAL TEKNOLOGI KESEHATAN DAN ILMU SOSIAL (TEKESNOS)
Publisher : Universitas Sari Mutiara Indonesia

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Porang tuber (Amorphophallus oncophyllus Prain) contains carbohydrates, fats, proteins, minerals, vitamins, and dietary fiber which are thought to be alternative growth media. This study aims to determine the growth of alternative media for microorganisms with Porang tubers. This research was conducted in the Pharmaceutical Chemistry laboratory, at Sari Mutiara University, Indonesia. Samples of Porang tubers were obtained from Porang plantations in the Amplas area, North Sumatra. This study uses an experimental method. Characterization of Porang tuber powder was found 9.54% water content, 9.09% water soluble extract content, and 1.43 total ash content.to contain%Secondary metabolites contained in Porang tuber starch were alkaloids and carbohydrates. The process of making starch begins with soaking with NaCl to remove the sap on the Porang tubers. Furthermore, the grating process is carried out until a precipitate of Porang tuber starch is found which will then be dried into Porang tuber starch. The manufacture of starch media respectively used a concentration of 5% (F1); 7.5% (F2) and 10% (F3). Then added agar, NaCl, and milk. Furthermore, microbiological tests were carried out using Staphylococcus aureus, Escherichia coli, and Candida albicans with the pour method. The comparison used is Nutrient agar and Potato dextrose agar. Furthermore, observations of the growth of these microorganisms were carried out. The results of the test Porang tuber starch showed yeast and bacteria growth media. The result of colony growth was found that the most colonies were found in formula 3 with Candida albicans as many as 297 colonies. The number of Staphylococcus aureus was found to be in formula 2 with 251 colonies, and for Escherichia coli, the most colonies were found in formula 3 with 143 colonies. Conclusion From the results of the study, it was found that Porang tubers can be used as growth media, Staphylococcus aureus, Escherichia coli, and Candida albicans.
Penetapan Kadar Vitamin C Secara Iodimetri Pada Paprika Hijau (Capsicum annuum L. Var. Grossum) Yang Tumbuh Disekitar Gunung Sinabung Setelah Erupsi Ginting, Ferdinand Paulus; Sembiring, Evarina; br Brahmana, Nettietalia; Nurazizah
JURNAL TEKNOLOGI KESEHATAN DAN ILMU SOSIAL (TEKESNOS) Vol. 4 No. 1 (2022): JURNAL TEKNOLOGI KESEHATAN DAN ILMU SOSIAL (TEKESNOS)
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Vitamin C is found in many fruits and vegetables, one of which is chilies and peppers. Paprika is thought to have the highest vitamin C content among other types of chili. This study aimed to determine vitamin C levels in green bell peppers (Capsicum annuum L. Var. Grossum) which grew around Mount Sinabung exposed to eruptions and green peppers that grew. far from Mount Sinabung which was not affected by the eruption Compared with the literature the content of vitamin C in fresh green bell peppers is 120 mg/100 g. The method used was an iodometric quantitative analysis method to determine vitamin C levels. The standard solution used was sodium thiosulfate 0 solution. .1 N and the titer solution used was 0.1 N iodine solution. The results of the determination of vitamin C levels in green peppers growing around Mount Sinabung which were affected by the eruption using quantitative analysis methods obtained levels of 104.67 mg/100 g and Green peppers growing far from Mount Sinabung that were not affected by the eruption were found to be 113.71 m g/100 g. The results of the study concluded that both samples experienced a decrease, from the original vitamin C content of fresh green peppers, which was 120 mg/100 g. This is caused by exposure to volcanic ash and hot steam generated by Mount Sinabung.
Uji Aktivitas Antioksidan Pada Teh Chamomile Kemasan Berdasarkan Variasi Suhu Dan Lama Penyeduhan Dengan Metode Dpph (1,1-diphenyl-2-picrylhydrazyl) Dhea Nur Fadhilah*; Binsar Sitorus; Tumpak Rudi Aman Manik; Eva Siburian
JURNAL TEKNOLOGI KESEHATAN DAN ILMU SOSIAL (TEKESNOS) Vol. 4 No. 1 (2022): JURNAL TEKNOLOGI KESEHATAN DAN ILMU SOSIAL (TEKESNOS)
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Antioxidants can neutralize free radicals and protect the body from various diseases by binding to free radicals and highly reactive molecules that can damage cells. Increased knowledge about free radical activity has resulted in the use of antioxidant compounds being increasingly developed for food, beverages, and treatment. Tea is a very popular drink and is consumed by almost all people in the world and become an important agricultural product, one of them is Chamomile tea. Chamomile tea comes from Chamomile flowers which contain lots of chemical compounds such as tannins and flavonoids namely: polyphenol compounds and their derivatives. Group of compounds Tea is one type of functional beverage because in tea is contained natural antioxidants, namely flavonoids that can keep the body from free radical attacks. This study aims to determine the influence of temperature and duration of brewing antioxidant power in the water of broom tea by using the DPPH method. This study used a randomized block design method (RAK), factor A is the brewing temperature (20˚C, 40˚C, and 50˚C) and factor B is the length of the brewing (2, 4, and 6 minutes) treatment combination of 9 treatments.The research results showed that with the higher temperature and duration of brewing the total content of the antioxidant power in tea steep also increased. And the combination of good performance based on the IC 50 test result is a combination of A3B3 (temperature brewing 50˚C for 6 minutes) with the highest total antioxidant equal to 232,4617 µg/mL sample. The result of a statistical test of Kurskal Wallis antioxidant activity of chamomile tea with a variation of temperature 20˚C, 40˚C, and 50˚C and brewing time 2 minutes, 4 minutes, 6 minutes there was a significant difference.
Potensi Tumbuhan Poguntano Sebagai Antidiabetes Julia Susanti; Cut Masyithah Thaib; Hana Ike Dameria Br Purba
JURNAL TEKNOLOGI KESEHATAN DAN ILMU SOSIAL (TEKESNOS) Vol. 4 No. 1 (2022): JURNAL TEKNOLOGI KESEHATAN DAN ILMU SOSIAL (TEKESNOS)
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Background: Diabetes is a dangerous degenerative disease. It even includes adiseasethatis classified as high risk because it can end in death. Diabetes is a heterogeneous syndrome whose overall symptoms are characterized by increased blood sugar levels caused by relative or absolute insulin deficiency. Based on research by Harahap, et al., 2013 and Febby, 2017 Poguntano has chemical compounds that have the potential as antidiabetic compounds, namely saponins as evidenced by the results of research with phytochemical screening results. This study aimstoexa mine the potential of the Poguntano plant as an antidiabetic. This research was conducted using the narrative review method, namely reviewing research articles, research journals, and these relating to the research subject, namely the Poguntano plant has the potential as an antidiabetic in the last 10 years, namely 2011-2021 through a search engine on Google Scholar database, PubMed, and Science Direct with the keywords “antidiabetic, Picria fel-terrae Lour.”. Then proceed with reviewing the articles so that a narrative review will be produced. Based on the results of the collection and selection of articles that have been carried out as the main references reviewed in this study, 11 references were obtained that met the inclusion criteria, research objectives, and journal quality. The results of research conducted by several researchers show that the poguntano plant has potential as an anti-diabetic and even the potency of poguntano is comparable to metformin which is generally used in the treatment of diabetes. Poguntano plant has antidiabetics properties. Where previous studies have conducted tests on animals as well as tests on humans and the results obtained that the poguntano plant is capable and very good at reducing diabetes levels.
Uji Aktivitas Antibakteri Ekstrak Etanol Dan Etil Asetat Daun Mangkokan (Polyscias scutellaria (Burm.f.) Fosberg.) Terhadap Pertumbuhan Bakteri Proteus vulgaris DAN Trichophyton mentagrophytes Syarifah Roslianizar; Hestina; Lina Br Tarigan, Frida; Nur Putri Dewi
JURNAL TEKNOLOGI KESEHATAN DAN ILMU SOSIAL (TEKESNOS) Vol. 4 No. 1 (2022): JURNAL TEKNOLOGI KESEHATAN DAN ILMU SOSIAL (TEKESNOS)
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Indonesia is a tropical country with a wide variety of plants, including the Mangkokan plant (Polyscias scutellaria (Burm.f.) Fosberg.). Mangkokan leaf (Polyscias scutellaria (Burm.f.) Fosberg.) is an ornamental or herbaceous plant. Mangkokan leaves contain compounds of alkaloids, flavonoids, saponins, and steroids/triterpenoids. These compounds are known to have antibacterial activity. The purpose of this study was to determine the antibacterial activity of the ethanolic and ethyl acetate extracts of the leaves of the Mangkukan (Polyscias scutellaria (Burm.f.) Fosberg.) against Proteus vulgaris and Trichophyton mentagrophytes bacteria and to determine the difference in the inhibition zones of the ethanol and ethyl acetate extracts of the leaves of the Mangkokan (Polyscias scutellaria (Burm.f.) Fosberg.) between the bacteria Proteus vulgaris and Trichophyton mentagrophytes. The extraction of the Mangkokan leaf was carried out by the maceration method using two solvents, ethanol 96% and ethyl acetate. The extracts obtained were screened for phytochemicals and tested for antibacterial activity against Proteus vulgaris and Trichophyton mentagrophytes using the agar diffusion method using paper discs with three repetitions and positive control administration of Ciprofloxacin and Ketoconazole. The results of the research on the diameter of the inhibition zone of the ethyl acetate extract showed the strongest antibacterial activity compared to the ethanol extract in inhibiting the growth of Proteus vulgaris and Trichophyton mentagrophytes. Antibacterial activity was tested by agar diffusion method using disc paper. Experiments using concentrations of 20%, 40%, 60%, and 80%. The difference in the zone of inhibition of the ethanol extract of the leaves of the Mangkokan (Polyscias scutellaria (Burm.f.) Fosberg.) against Proteus vulgaris bacteria was 9,4 mm, and for Trichophyton mentagrophytes it was 9,6 mm. The difference in the inhibition zone of the ethyl acetate extract of the leaves of the Mangkokan (Polyscias scutellaria (Burm.f.) Fosberg.) against Proteus vulgaris bacteria was 10,06 mm and for Trichophyton mentagrophytes it was 10,42 mm.
Uji Aktivitas Ekstrak Etanol Daun Salam (Syzygium polyanthum) Terhadap Pertumbuhan Bakteri Methicilin-Resistant Staphylococcus aureus Nuranti Rumela Sirait; Rosina Sitohang; Arman Bemby Sinaga; Maya Sari
JURNAL TEKNOLOGI KESEHATAN DAN ILMU SOSIAL (TEKESNOS) Vol. 4 No. 1 (2022): JURNAL TEKNOLOGI KESEHATAN DAN ILMU SOSIAL (TEKESNOS)
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Bay leaf (Syzygium polyanthum) is a family of Myrtaceae, which has been widely used as a spice in the kitchen, it turns out that it can be used as a traditional medicine to treat various diseases such as diabetes mellitus, hypertension, diarrhea, cholesterol, gastritis, and gout. Bay leaf (Syzygium polyanthum) can be used as a traditional medicine to maintain health and prevent various diseases because it contains alkaloid compounds, tannins, flavonoids, essential oils, and saponins. Methicillin-Resistant staphylococcus aureus (MRSA) is a cause of bacterial infections such as bacteremia, pneumonia, and surgical wound infections. Methicillin-Resistant Staphylococcus aureus can cause various complications, often in the bloodstream, joints, lungs, bones, and heart. This study was conducted with the aim of knowing the antibacterial activity of the ethanolic extract of bay leaves (Syzygium polyanthum) with concentrations of 5%, 10%, 15%, 20%, and 25% against the growth of Methicillin-Resistant staphylococcus aureus bacteria. This research method uses an experimental method, namely to determine the antibacterial activity of ethanol extract from bay leaves (Syzygium polyanthum) against the growth of Methicillin-Resistant staphylococcus aureus bacteria. This research used 96% ethanol as solvent. The test was carried out through several stages including material collection, preparation of Simplicia, manufacture of ethanol extract from bay leaves by maceration, and testing of antibacterial activity against Methicillin-Resistant staphylococcus aureus bacteria. Based on the results of phytochemical screening tests, the thick extract of bay leaf contains a class of alkaloids, flavonoids, glycosides, saponins, and tannins. The results of the antibacterial activity test of thick bay leaf extract against Methicillin-Resistant staphylococcus aureus bacteria had an average inhibitory activity at concentrations of 5% (6.55 mm), 10% (7.5 mm), 15% (8 mm), 20 % (8.8 mm) and 25% (11.06 mm).