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Medula
Published by Universitas Lampung
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Core Subject : Health, Science, Education,
Education Medicine & Pharmacology Neuroscience Public Health
Medical Profession Journal of Lampung didirkan pada tahun 2013. Medula hadir memenuhi kebutuhan publikasi jurnal bagi mahasiswa Fakultas Kedokteran, Dosen ataupun klinisi dan profesi lain dibidang kedokteran. Medula diterbitkan dengan frekuensi 4 kali dalam setahun yang tiap nomornya mencakup 30 jenis artikel ilmiah seperti artikel penelitian, laporan kasus, tinjauan pustaka dan lain-lain. Medula sudah memiliki nomor ISSN media cetak sejak tahun 2013
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 30 Documents
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Search results for , issue "Vol 10 No 4 (2021): Medula" : 30 Documents clear
Efektivitas Nutrasetikal sebagai Agen Kemopreventif dalam Melawan Sel Kanker Payudara Tesya Agustin; Ratna Dewi Puspita Sari
Medula Vol 10 No 4 (2021): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v10i4.126

Abstract

Cancer is the leading cause of death with breast cancer cases that occupies the highest incidence rate in Indonesia. Breast cancer is a growth of abnormal cells in the epithelium of the ducts or lobules of the breast, causing malignancy in the breast tissue. Beacuse the breast cancer is the most common cancer case, so early detection is carried out and accompanied by recommendations for the most effective treatment for confirmed patients. However, some of these therapies trigger unexpected side effects, then a lot of efforts were made to prevent and control the growth of malignant cells in breast cancer. This malignancy can be inhibited by consuming nutraceutical, which is a combination of nutrition and pharmaceuticals. Nutraceutical is a type of food whose nutritional composition has benefits for health, both prevention and treatment of a disease. The chemopreventive components in fruit and vegetables that are classified as nutritional, besides having effect on health, also having the potential for the anti-carcinogen and anti-mutagenic action. The compounds contained in it are able to against cancer cells with minimal side effects. There are many of them such as ginger, turmeric, cruciferous vegetables, soybeans, tomatoes, garlic, black cumin, and pomegranate have potential anticancer action by reducing the growth of cancer cells, inhibiting cell proliferation, and inducing apoptosis of cancer cells. Thus, nutracetical has potential as a chemopreventive agent with various mechanism of action to against breast cancer cells effectively.
Pengaruh Pemberian Ekstrak Biji Kopi Robusta Lampung (Coffea canephora) terhadap Nilai Elevated Plus Maze (EPM) Kecemasan Tikus Putih Jantan (Rattus novergicus) Galur Sprague dawley yang Diinduksi Monosodium Glutamat (MSG) Adillah Afrilia Syahwina Pado; Anggraeni Janar Wulan; Eca Cania B
Medula Vol 10 No 4 (2021): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v10i4.129

Abstract

Anxiety can be triggered by consuming MSG through the mechanism of oxidative stress. Lampung Robusta coffee bean extract contains polyphenols, given as an antioxidant and neuroprotective. To know the effect of the giving of Lampung Robusta Coffee Bean extract (Caffea canephora) to the value of Elevated Pus Maze (EPM) Anxiety of Male White Rats (Rattus novergicus) Sprague Dawley strain induced by Monosodium Glutamate (MSG). Experimental research with Posttest Only Control Group Design. This study used 25 Sprague Dawley (Rattus norvegicus) male rats randomly selected and divided into 5 groups namely, K1 (negative control), K2 (MSG 2g / kgBB / day), P1 (MSG 2g / kgBB / day + coffee 0.5mg / ml), P2 (MSG2g / kgBB / day + coffee 1mg / ml) and P3 (MSG2g / kgBB / day + coffee 2mg / ml). The mean duration (seconds) on the open arm was K1 78.6 ± 62.9, K2 4.2 ± 9.3, P1 5.0 ± 7.8, P2 10.0 ± 13.6 and P3 14.8 ± 13.5. The mean duration on the closed arm was K1 141.8 ± 105.0, K2 271.2 ± 33.7, P1 285.2 ± 12.9, P2 266.2 ± 32.7 and P3 261.2 ± 15.6 Kruskal-Wallis test on the open arm 0.006 (p <0.05) and 0.026 on the close arm (p <0.05). The Mann-Whitney U test found a significant difference between the K1 and K2 groups and there was no significant difference between the P1, P2, and P3 groups in the open and close arms. There was no effect of giving Lampung Robusta Coffee Bean extract on the value of Elevated Plus Maze (EPM) Anxiety Male White Rats (Rattus novergicus) Sprague dawley strain induced by Monosodium Glutamate (MSG).
Penatalaksanaan Holistik pada Lansia dengan Isolated Systolic Hypertension (ISH), Suspek Retinopati Hipertensi dan Imobilitas: Penatalaksanaan Holistik pada Lansia dengan Isolated Systolic Hypertension (ISH), Suspek Retinopati Hipertensi dan Imobilitas Karimah Khitami Aziz; Dian Isti Angraini
Medula Vol 10 No 4 (2021): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v10i4.130

Abstract

Isolated Systolic Hypertension (ISH) is an increase of systolic blood pressure (BP) without diastolic BP common in old age. ISH may develop from a history of chronic essential hypertension or result from arterial stiffness in normotensive person. Secondary causes of arterial stiffness are type 1 diabetes, osteoporosis with calcification, atherosclerosis, peripheral vascular disease, thyrotoxicosis and aortic disorders. Implementation of family medicine and evidence based medicine by identifying risk factors, clinical problems and management based on a patient centered and family approach. This study is a case report. Primary data were obtained through history taking, physical examination and home visit. The assessment based on the holistic initial diagnosis, process and final diagnosis by in-depth interviews, observation and notes. The patient complained of intermittent headaches and blurred vision since 1 week ago. Complaints for the first time and never been treated. The patient's concern with the complaint interferes with his activities and rest. The patient's expectation of complaints is reduced and not worsen. Patients' perceptions of complaints occur due to certain lifestyles causing diseases that are not known for sure by patient and their family. The patient was diagnosed with grade II ISH. The patient's father had history of hypertension and heart disease. The patient's treatment pattern is curative, rarely has light physical activity, lack of knowledge about the disease, inappropriate diet and eating habits, elderly age and lack of family knowledge about the disease and its complications. Functional degree 2. After the intervention shows clinical improvement and changes in behavior. ISH in the elderly with insufficient knowledge about risk factors, drug use and adherence to BP control can cause acute and advanced complications.
A Laporan Kasus: Wanita 58 Tahun dengan Ptosis Oculi Sinistra et causa Paresis Nervus Oculomotor (CN III) Incomplete-Without Pupillary Involvement Alfia Nikmah; Sisca Mayasari
Medula Vol 10 No 4 (2021): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v10i4.135

Abstract

Ptosis is a condition when the palpebrae drop from their normal position. Ptosis describes the dropping of the upper eyelid  so that it covers half or all of the pupils which can disturb the vision. This condition got worse in downgaze position. Based on its onset, ptosis is divided into congenital and acquired. Neurogenic ptosis is the most common aquired ptosis, mainly due to paresis oculomotor nerve (CN III). In the elderly, it is necessary to suspect the paresis due to ischemia, especially in patients with underlying systemic disease. This case report describes a 48 year old woman with the chief complaint of painless upper eyelids ptosis since 4 months ago. Initially it was only partially closed, and the last 2 months it became completely closed. Visual acquity of the left eye  6/60, eye movements were full, pupil were equal and reactive, Relative Afferent Pupillary Defect (RAPD) were not found, and normal Bell’s phenomenon. Margin Reflex Distance (MRD)-1 score-5 mm, Interpalpebral Fissure (IPF) score 0 mm, and  poor levator function 0 mm. The anterior segment is within normal limits. Laboratory tests, head CT scan, and MRI were within normal limits. Based on the results of the history, ophthalmological examination, and investigations, the patient was diagnosed with ptosis ocular sinistra et causa nerve oculomotor (CN III) paresis incomplete-without pupillary involvement. The patient get non-steroidal anti-inflammatory drugs, observation, and planned for frontalis sling surgery.
A Hiperleukositosis pada Pasien dengan Kanker Paru Divian Ozaza Sari; Yusuf Aulia Rahman
Medula Vol 10 No 4 (2021): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v10i4.136

Abstract

Leukocytosis can be found in patients with lung cancer at the time of diagnosis or during the course of the disease. Hyperleukocytosis was defined as a leukocyte count above 11.000/mL on pheripheral blood. This case report describes hyperleukocytosis in a paraneoplastic syndrome resulting from lung cancer in a 42-year-old man who has had fever and weakness since the last 3 months. Peripheral blood morphological examination, there is increased leukocyte, 88% segment neutrophils, no blast cell and negative BCR-ABL examination. In people with lung cancer, leukocytosis can be caused by infection, use of corticosteroid,  hematopoietic disorders, bone marrow involvement, or paraneoplastic manifestations. Paraneoplastic leukocytosis is associated with poor prognosis and aggressive disease, so the diagnosis of hyperleukocytosis in paraneoplastic syndromes is important because it determines the patient's prognosis. Paraneoplastic syndrome is a symptom seen in certain malignancies and is not associated with direct cancer invasion and occurs in 7-15% of all patients with cancer. Solid tumors activate a variety of different systems, namely the endocrine, neurological, mucocutaneous, and hematological systems. Granulocyte Macrophage Colony Stimulating Factor (GM-CSF), Granulocyte Colony Stimulating Factor (G-CSF), interleukin (IL) -1, IL-6 and Tumor Necrosis Factor (TNF)-α have been implicated in paraneoplastic leukemoid reactions. Among these, G-CSF is the strongest cytokine that triggers hyperleukocytosis.
A Penatalaksanaan Holistik Penyakit Tuberkulosis Paru dengan Gout Arthritis pada Wanita Usia 41 Tahun Melalui Pendekatan Kedokteran Keluarga Betari Ariefia; Azelia Nusadewiarti
Medula Vol 10 No 4 (2021): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v10i4.138

Abstract

Indonesia is the second country with the highest incidence of TB cases in the world in 2020. New TB cases in Indonesia is 543,874 cases in 2020 (20 March 2020). Meanwhile, there were 777 new TB cases in Lampung province (June 2020). The increase in TB infection is influenced by several factors, age, gender, nutritional status, level of cleanliness, ventilation, temperature, lighting, occupant density, and education. Gout arthritis is an inflammatory joint disease that is influenced by the intake of high-purine foods or other factors such as anti-tuberculosis drugs. Pyrazinamide can inhibit uric acid excretion in the kidneys and increase the value of blood uric acid. Therefore, it takes the role of a family doctor who can manage patients from various aspects. The aim of research is to apply a holistic and comprehensive family doctor approach in detecting internal and external risk factors and solving problems based on Evidence Based Medicine which is family-approached and patient-centered. This study is a case report. Primary data from autoanamnesis, physical examination, and home visits. Secondary data from patient medical records. The patient has functional grade 2 in pulmonary TB disease and Gout Arthtitis with internal risk factors, the patient's lack of knowledge of the disease and curative treatment behavior; External factors are low income families, home environment is close to dusty and slum areas. The intervention are education for control according to schedule, cough ethics and TB transmission, and low-purine diet. In the evaluation there are changes in the patient's behavior and diet.
Efektivitas pengajaran klinik di RSUD dr. H. Abdul Moeloek Provinsi Lampung Restu Cyntia Permatasari; Merry Indah Sari; Dwita Oktaria; Oktafany
Medula Vol 10 No 4 (2021): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v10i4.142

Abstract

Clinical Clerkships refers to a program designed for medical students to qualify a competent doctor. This program is carried out in the teaching hospital, network hospitals, community health center (Puskesmas) and companies. The aim of the study was to determine the effectiveness of clinical teaching in the RSUD Dr. H. Abdul Moeloek of Lampung Province. This study was a descriptive study using a purposive sampling. The subject of this research were 29 clinical clerkships students in the first data retrieval, and 21 each in the second and third data retrieval in the Department of Surgery at the RSUD Dr. H. Abdul Moeloek of Lampung Province. The data was collected using The Clinical Teaching Effectiveness Instrument (CTEI) and analyzed using univariate analysis.This study showed the overall effectivity of the clinical teaching in RSUD Dr. H. Abdul Moeloek of Lampung Province. Average category was the most frequent accounted for 91.67% while 8.33% cases was in the Good category. The Clinical Teaching Effectiveness in Dr. RSUD H. Abdul Moeloek of Lampung Province was in Average category.
Hubungan Otitis Media Akut Dengan Riwayat Infeksi Saluran Pernapasan Atas Pada Anak Lidya Angelina Purba; Mukhlis Imanto; Dian Isti angraini
Medula Vol 10 No 4 (2021): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v10i4.145

Abstract

Children are very susceptible to Acute Otitis Media (AOM) because the anatomical shape of the eustachian tube is shorter, more flexible and more horizontal than adult. Two thirds of all children have an episode of acute otitis media in the first 3 years of life. Upper Respiratory Tract Infection (ARI) is one of the most common risk factors for causing acute otitis media (AOM) in children. This is because the inflammatory process that occurs in ARI causes damage to mucocilia, goblet cells, and mucus glands in the epithelium of the nasopharynx and middle ear. Children aged under 5 years will usually experience upper respiratory tract infections of two to seven episodes per year. Children who have frequent episodes of ARI are more likely to experience episodes of AOM. his is also in line with repeated episodes of ARI against the risk of AOM recurrence. Recurrent ARI is an ARI that occurs at least four times a year. Therefore, the diagnosis and management of ARI in children as early as possible must be done properly, so that the incidence of ARI in children does not progress to AOM. The causes of otitis media are multifactorial, the anatomical variation of the eutachian tube, and the invasive ability of the pathogen compared to the human's immune system. The diagnosis of otitis media can be confirmed by fulfilling 3 criteria: sudden appearance of the disease, found signs of effusion (known fluid) in the middle ear, found signs of middle ear inflammation.
daun Daun Salam (Syzygium Polyanthum) Sebagai Penurun Kadar Kolesterol Dalam Darah Aditya Ramadhon Islami Sakaganta; Asep Sukohar
Medula Vol 10 No 4 (2021): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v10i4.146

Abstract

Coronary Heart Disease (CHD) is a major health problem in developed or developing countries. CHD is classified as a degenerative disease related to lifestyle, and socio-economic community. In 2008 it was estimated that 17.3 million deaths were caused by cardiovascular disease. The prevalence of hypercholesterolemia in Indonesia according to riset kesehatan dasar (riskesdas) in 2013 was obtained by Indonesians with higher than normal cholesterol levels higher in women by 39.6% when used with men by 30%. The full scientific bay leaf plant has the Latin name Eugenia polyantha Wight and has another scientific name, namely syzygium polyantha wight and eugenia lucidula miq. This plant belongs to the myrtaceae tribe. Bay leaf contains essential oils of 0.17%, citral, eugenol, tannin, flavonoids, and metal cavikol. Substances that are significant in lowering cholesterol are flavonoids and tannins. How flavonoids work in reducing cholesterol occurs when the hydroxyl group on cholesterol is considered with the ketone group on flavonoids forming hemiasetal. The carbonyl group in flavonoids will choose the hydroxyl group in cholesterol to determine the hydrogen bond. Tannins work quickly in binding and shrinking proteins. Tannin works as an antioxidant, astringent, and hypocholesterolemic. Tanninakan with mucous protein and intestinal epithelial cells so it needs to prevent fat.
Pengaruh Asupan Asam Folat Maternal terhadap kejadian Neural Tube Defect Arina Muti Amaliah; Ratna Dewi PS
Medula Vol 10 No 4 (2021): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v10i4.150

Abstract

Neural tube defects (NTDs) are common complex congenital malformations resulting from failure of the neural tube closure during embryogenesis. Human NTDs are multifactorial, with contributions from both genetic and environmental factors. The genetic basis is not yet well understood, but several nongenetic risk factors have been identified as have possibilities for prevention by maternal folic acid supplementation. Congenital abnormalities included in NTD include anencephaly, encephalocele, cranial meningocele, myelomeningocele, spinal meningocele, lipomeningocele, spina bifida, and several other brain defects. Spina bifida and anencephaly are the two most common forms of NTD. The incidence of NTD can be caused by several risk factors such as nutritional status, prevalence of obesity and diabetes, use of folic acid supplements and / or fortification, presence of toxicity in the environment, and different genetic predispositions between ethnic groups. The genetic basis is not well understood, but several non-genetic risk factors have been identified as likely to be prevented by maternal folic acid supplementation. The incidence of NTD can be reduced if women consume a folic acid supplement before and during the early weeks of pregnancy.Folate is involved in the methylation process of homocysteine ​​and cytosine. It also contributes to the synthesis of purines and pyrimidines. As a result, a lack of folate causes an inability to properly build proteins and DNA and also changes the expression of some genes. Although the role of folate in reducing the risk of NTDs is unknown, women of reproductive age are encouraged to include folate supplements in their diets.

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