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Medula
Published by Universitas Lampung
ISSN : -     EISSN : 97726154     DOI : -
Core Subject : Health, Science, Education,
Education Medicine & Pharmacology Neuroscience Public Health
Medical Profession Journal of Lampung didirkan pada tahun 2013. Medula hadir memenuhi kebutuhan publikasi jurnal bagi mahasiswa Fakultas Kedokteran, Dosen ataupun klinisi dan profesi lain dibidang kedokteran. Medula diterbitkan dengan frekuensi 4 kali dalam setahun yang tiap nomornya mencakup 30 jenis artikel ilmiah seperti artikel penelitian, laporan kasus, tinjauan pustaka dan lain-lain. Medula sudah memiliki nomor ISSN media cetak sejak tahun 2013
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 30 Documents
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Search results for , issue "Vol 10 No 4 (2021): Medula" : 30 Documents clear
Manajemen Preoperatif dan Anestesia Pasien Geriatri Dita Mauliana Prabiwi; Ari Wahyuni
Medula Vol 10 No 4 (2021): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v10i4.153

Abstract

Geriatric patients are elderly patients over 60 years of age and have multi-pathological characteristics whose symptoms are atypical with decreased physiological reserve and are usually accompanied by functional disorders. Up to 60 years of age, both basal organ function and physiological reserve are well preserved. Furthermore, the physiological reserve function will decrease. In addition to the pharmacokinetic changes in drug metabolism associated with aging, pharmacodynamic changes can also alter drug response in geriatric patients. The preoperative evaluation and assessment in elderly patients is usually more complex than in younger patients because of the heterogeneity and the increased frequency and severity of comorbidities associated with aging. In addition, perioperative functional status may be difficult to evaluate. Aging produces changes in physiology that are linked to reduced functional reserves and the ability to compensate for physiological stress. As a result, the consumption of several drugs typical of elderly patients can alter the homeostatic mechanism. Elderly patients are at greater risk of long-term functional impairment after the stress of surgery than younger patients. In general, elderly patients with complex medical histories should be given more attention before surgery to ensure that they are properly prepared. All elderly patients should undergo preoperative evaluation and preparation of anesthesia as well as relevant consultations.
Hububgan Hubungan Riwayat Merokok, Konsumsi Alkohol dan Diabetes dengan Derajat Histopatologi Karsinoma Kolorektal di RSUD Dr. H. Abdul Moeloek Bandar Lampung Periode 2017-2018 Gede Ardi Saputra; Rizki Hanriko; Hendri Busman; Muhartono
Medula Vol 10 No 4 (2021): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v10i4.154

Abstract

Colorectal carcinoma is a malignant neoplasm which originating or growing in the colon or rectum. Colorectal carcinoma is one of the 10 most common cancers suffered by Indonesians. Carcinomas develop much less in the duodenum, jejunum, and ileum than in the colon and rectum. The duodenum, jejunum, and ileum join the colon in the lower right abdomen. In the early stages most cancers do not show any particular clinical symptoms, however, early testing can minimize a poor prognosis. Screening or screening for colorectal carcinoma can be performed in groups of men and women over 50 years of age or patients who are at risk of developing colorectal carcinoma. Screening should also be done by people with polyps or individuals at risk of other carcinomas. The purpose of this study was to determine the frequen distribution and the relationship between smoking history, alcohol consumption history and diabetes history to the histopathological degree of colorectal carcinoma in RSUD Dr. H. Abdul Moeloek. This research was conducted in October-November 2019 at Dr. H. Abdul Moeloek Bandar Lampung using the observational method. The sample of this study consisted of 94 people with medical record data determined using total sampling techniques. Data were processed using statistical tests with a confidence level of 0.05. Chi-square test results showed that there is a  correlation between smoking history (p = 0.0008), alcohol consumption (p = 0.006) and diabetes mellitus (p = 0.015) with the histopathological degree of colorectal carcinoma. So, it can be concluded there is a correlation between smoking history, alcohol consumption and diabetes.
Pengaruh Pemberian Ekstrak Teh Hijau (Cammelia Sinensis) Terhadap Gambaran Histopatologi Silia Pada Trakea Tikus Putih Jantan Galur Sprague Dawley yang Dipapar Uap Rokok Elektronik Ahmad Syah Putra; Susianti; Rizki Hanriko
Medula Vol 10 No 4 (2021): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v10i4.156

Abstract

At present, there is a shift in the use of cigarettes, from conventional cigarettes to e-cigarettes. Exposure to particulate e-cigarettes can cause damage to the airway, one of which is ciliary tracheal. Green tea (Camellia sinensis) has a source of antioxidants in the form of polyphenols which can reduce the number of organ damage through a mechanism as an anti-oxidant. The study used an experimental design using 30 Sprague Dawley strain white rats which were divided into 6 groups, namely 3 control groups and 3 treatment groups. In the control group, given regular treatment, exposure to electric cigarettes and exposure to conventional cigarettes. In the treatment group, mice were given peritoneal injection of green tea extract each of 50 mg/kg body weight, 100 mg/kg body weight, and 200 mg/kg body weight. After 14 days of treatment, the 15th day of mice was euthanized and preparations were taken. There was a change in histopathological damage in all samples where there were significant differences in the control group, but not significantly in the treatment group with a value of K1 to K2 with p = 0.005, and K1 to K3 with p = 0.007. Whereas in vape control group (K2) between treatment groups P1, P2, and P3 were p = 0.521.There is not difference between the administration of green tea extract to histological ch es in cilia’s tracheal structure of rats exposed to steam electronic cigarettes with p=0,521.
Laporan Kasus : Bayi 3 Bulan dengan Ulkus Kornea Ocular Dextra et causa Koloboma Palpebra Superior Ocular Dextra Rani Himayani; Farhandika Muhammad
Medula Vol 10 No 4 (2021): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v10i4.157

Abstract

Coloboma is a condition of congenital malformation in which the ocular structures are not fully formed due to failed fusion of the optic fissure during the embryonic development. The resulting defects can affect different structures, such as the eyelids, iris, lens, ciliary body, choroid, optic nerve, and retina.Eyelid coloboma is a congenital disorder that can occur unilateral or bilateral, partially or completely. This is due to the failure of mesodermal fusion during eyelid embryogenesis. There is no fusion between contigous tissue, the failure of the mesenchyme to fill the embryogenic process, and the result of necrosis due to the suppression effect of the amniotic band syndrome. This case reports a 3 month old baby with a chief complaint of white part  on right eye since 15 days. The complaint was initiated with the patient being born without a complete right eyelid. The ophthalmology examination of the right eye found that the sharp vision of the baby began to be able to follow the moving object that was seen, but the baby did not follow the instructions to see from one object to another without having to move his head, the pupil diameter was the same in both eyes, with normal pupillary reflex. Eyelid inspection found a coloboma on the right upper eyelid. In the sclera and limbus, there was minimal ciliary injection, the cornea was cloudy, the front chamber was shallow and it looked positive.Based on the history, physical examination, and investigations, the patient was diagnosed as right ocular corneal ulcer et causa coloboma of the superior ocular palpebrae. Medical management by administering antibiotic therapy and artificial tears, and in the patient planned operative action in the form of reconstruction of the superior palpebra on the oculi dextra.
Rabdomiosarkoma Helmi Ismunandar; Rani Himayani; Diki Prawira Adifa
Medula Vol 10 No 4 (2021): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v10i4.158

Abstract

Rhabdomyosarcoma is a soft tissue malignancy with prevalences about 5% of all malignancies in children and 20% of soft tissue malignancies that occur in children. The most common primary tumor sites include the head and neck area followed by the genitourinary and extremities. Meanwhile, the most common subtypes are embryonic in children and alveolar in adolescents. Although the specific etiology for RMS is largely unknown, there are increased risk factors for environmental factors such as radiation and drugs, syndromes, and chromosomal abnormalities. The clinical symptoms vary and are related to the location of the mass and the blockage it caused. Histopathological and immunohistochemical examinations are gold standard tests for diagnosing RMS and determining subtypes that serve as prognosis and therapy. Various therapeutic approaches can be surgery, chemotherapy, radiotherapy, or in a combination.
KORELASI PANJANG TULANG FEMUR TERHADAP TINGGI BADAN DAN USIA PADA PRIA DEWASA SUKU BUGIS DI KOTA KARANG KECAMATAN TELUK BETUNG TIMUR KOTA BANDAR LAMPUNG Anggraeni Janar Wulan; Hendro Sihaloho
Medula Vol 10 No 4 (2021): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v10i4.159

Abstract

Estimates of height based on bone length is the femur bone are the most widely used methods, because they have good correlation coefficient values. This study was conducted using a descriptive analytical method with a cross sectional approach to 38 subjects who were over 21 years old and there were no bone abnormalities. The averages of height Bughis is 162,758 ± 6,09, length of femur bone Bughis right is 33,2 ± 3,09 and left is 32,158 ± 2,86. By using Pearson correlation analysis, the value of r = 0.855 for the right femur bone with height and r = 0.862 for the left femur bone with height very strongthWhich means a very strong relationship between the length of the femur bone with height. And the Bughis regression formula to estimate of height is Y = 106,767 + 1,683X (right) and Y = 102,026 + 1,835X (left), meanwhile Y = estimated height (cm) and X = Femur Bone Length. And for the correlation of femur length with age, r = -0.206 for the right femur bone and r = -0.223 for the left femur bone is weak. There is correlation of femur bone length to height and age in Bughis adult men at Karang City East Teluk Betung Subdistrict Bandar Lampung City.
Rakhitis: Tinjauan Pustaka Helmi Ismunandar; Rani Himayani; Maula Al Farisi
Medula Vol 10 No 4 (2021): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v10i4.163

Abstract

Vitamin D and calcium are important nutrients in bones. Bone growth and mineralization are dependent on the availability of adequate calcium and phosphate. Due to the lack of mineralization in the bone plates it causes rickets. Rickets is the most common bone disease worldwide and became known in 1650’s when it first appeared in Europe. Rickets can have a profound impact on the health, growth and development of infant’s, children’s and adolescent’s which can result in death or persistence to adult. Rickets is a metabolic disease of the bones, that is often associated with vitamin D deficiency and decreased circulating calcium storage, mainly due to a lack of bone capacity to absorb the calcium. Usually people with rickets have a short stature and have joint disorders. There are several types of rickets, such as rickets type-1 and type-2 that depend on vitamin D (but in type-2 rickets involves a genetic disorder related to the FGF23 gene), renal rickets due to decreased of kidney function, rickets hypocalcemia caused by deficiency of calcium, and hypophosphatemic rickets caused by deficiency of phosphate. Rickets can be diagnosed based on history, physical examination, radiological examination and biochemical tests.
Ruptur Tendon Achilles: Tinjauan Pustaka Helmi Ismunandar; Rani Himayani; Ranti ayu puspita Alwi
Medula Vol 10 No 4 (2021): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v10i4.165

Abstract

The Achilles tendon (AT) is the most frequently ruptured tendon in the human body but its etiology is poorly understood. Achilles tendon rupture (44% to 83%) occurs during sports activities, intrinsic structural, biochemical, and biomechanical changes associated with aging. The two main explanations for mechanism are degenerative and mechanical theories. The diagnosis of AT rupture is based on a history of such a sudden feeling of pain in the heel, sometimes accompanied by a pounding sound during activity. Specific physical examinations that can be done are the Simmonds or Thompson squeezed test, O'Brien's test, the matles or knee flexion test, and the Copeland test or sphygmomanometer. The diagnosis can be made by a good history and physical examination. Imaging is usually not required, as a diagnosis can be made clinically. Ultrasound or magnetic resonance imaging (MRI) can help if the diagnosis is not clear (partial rupture or tendonopathy). Non-operative and operative management may be options. The initial management of Achilles tendon rupture is rest, elevation, pain control, and functional support. For most patients with Achilles tendon rupture, the prognosis is very good. However, in some non-athletic patients, there may be some residual deficits such as reduced range of motion. No matter which method is used to treat tendon ruptures, participating in exercises is very important.
Efek Anti-Mikrobial pada Ekstrak Cinnamomum verum (Kayu Manis) sebagai Terapi Adjuvant pada Malaria Falciparum Khairun Nisa; Fitria Putridewi Abidin
Medula Vol 10 No 4 (2021): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v10i4.167

Abstract

Malaria is a major public health problem in the world, especially in Indonesia. The prevalence of malaria in Indonesia reaches 6 percent with 2000 deaths each year, most of which are caused by Plasmodium falciparum. Various treatment options for falciparum malaria have been developed, but due to various factors, one of which is the adherence of patients who are not monitored medication, increases the risk of resistance to current malaria therapy. Therefore, the researchers conducted further research on alternative malaria therapies. Cinnamomun verum or cinnamon is known to contain cinnamaldehyde compounds which have antimicrobial properties. The purpose of this study was to determine the anti-microbial effect of Cinnamomun verum (cinnamon) extract as an adjuvant therapy in falciparum malaria. This literature review article takes 25 case report articles, research articles, and literature reviews. The conclusion of this study is that the cinnamaldehyde compound in the extract of Cinnamomun verum has an antiparasitic effect which can inhibit the denaturation potential of amino acids, inhibits β-hematin formation and activity of the reductase enzyme on Plasmodium falciparum enoyl-ACP reductase. It is known that these four things have an important role in the pathogenesis of falciparum malaria.
Hubungan Rinitis Alergi Dengan Rinosinusitis Kronik Zhafran Ramadhan Lumbantobing; Mukhlis Imanto
Medula Vol 10 No 4 (2021): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v10i4.168

Abstract

Chronic rhinosinusitis is an inflammatory and infectious disease of the paranasal sinuses with the characteristics of 5 major symptoms that have occurred for at least 12 weeks: nasal congestion, pain or pressure on the face, nasal obstruction, the presence of secretions in the nose anterior and posterior, and loss of smell. Allergic rhinitis is the most common predisposing factor for chronic rhinosinusitis because it is associated with obstruction of sinus ostium due to mucosal edema. As many as 50% - 84% of patients with chronic rhinosinusitis have a history of atopy to dust, fungi and allergies to animal hair and an increase in serum specific IgE antibodies and peripheral eosinophils associated with the onset of symptoms of chronic rhinosinusitis. In chronic rhinosinusitis patients with allergic rhinitis, hypersensitivity reaction occur and an increase in the number of inflammatory mediators such as histamine, proinflammatory cytokines such as interleukins, TNF-α (tumor necrosis factor), GM-CSF (granulocyte-macrophage colony stimulating factor) is more in the nasal mucosa compared with chronic rhinosinusitis patients without allergic rhinitis. All these inflammatory mediators will then lead to increased vascular permeability and hypersecretion of the mucus glands. The inflammatory process caused by allergic rhinitis will cause blockage of the ostiomeatal complex, impaired mucocilliary clearance, and impaired ciliary function resulting in paranasal sinus obstruction which will lead to chronic rhinosinusitis. It is very important for patients with allergic rhinitis to be managed properly both pharmacologically and non-pharmacologically in order to help prevent the occurrence of chronic rhinosinusitis.

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