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Pharmaciana: Jurnal Kefarmasian

PHARMACIANA
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Published by Universitas Ahmad Dahlan

ISSN : 20884559 EISSN : 24770256 DOI : 10.12928

Core Subject : Health,

Medicine & Pharmacology

Pharmaciana is a scientific journal published by the University of Ahmad Dahlan worked closely with Ikatan Apoteker Indonesia (IAI). Pharmaciana published three times a year, namely March, July and November. with ISSN 2088-4559 and e-ISSN 2477-0256. The article published in the Journal Pharmaciana selected by editors and reviewed by the reviewer. Articles published in Pharmaciana must not be published in other journals or have been previously published. Pharmaciana is indexed in google scholar, ACI (Asean Citation Index), Dimension (Crossreff), Garuda, Sinta, Sherpa Romeo, Index Copernicus International, DOAJ, and BASE. Pharmaciana is accredited by DIKTI (DGHE) of Indonesia No. 105/E/KPT/2022 April 07, 2022

Arjuna Subject : Kimia(semua kategori) - Kimia (Lain-Lain)

Articles 13 Documents

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Search results for , issue " Vol 5, No 2 (2015): Pharmaciana" : 13 Documents clear

PENINGKATAN SISTEM IMUN OLEH KOMBINASI EKSTRAK ETANOL DAUN AWAR â AWAR (Ficus septica burm. F) DAN EKSTRAK ETANOL DAUN KELOR (Moringa oleifera) SEBAGAI KO-KEMOTERAPI KANKER PADA TIKUS PUTIH BETINA GALUR SPRAGUE DAWLEY YANG DIINDUKSI DOKSORUBISIN Anovia, Rizka Angerti; Sari, Dewi Indah; Yazin, Annisa Hardikasari; Ismayani, Ulfa; Darmawan, Endang
Pharmaciana Vol 5, No 2 (2015): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Use of the drug doxorubicin for cancer therapy causes decreasing of immune system reported. Leaves of Ficus septica Burm. F and leaves of Moringa oleifera as immunostimulatory agents. The purpose of this study, among others, determine the combined effects of ethanol extract of Ficus septica Burm. F leaves and ethanol extract of Moringa oleifera leaves as co-chemotherapy for in female rats Sprague Dawley strain induced doxorubicin. Eighteen Sprague Dawley rats were divided into six treatment groups, normal group was given 0.9% NaCl 10ml / kgBB, positive control group were given by doxorubicin with dose of 4.67 mg / kgBB, single-dose treatment group were each given ethanol extract of Ficus septica Burm F leaves dose of 750 mg / kgBB and ethanol extract of Moringa oleifera leaves 500 mg / kgBB, treatment groups were given by combination of ethanol extract Ficus septica Burm. F leaves and Moringa oleifera leaves with a dose of 1.25 g / kgBB and a dose of 1 , 75 g / kgBB. treatment carried out for 7 days. On days 1 and 4 of each treatment groups except the normal group induced by doxorubicin 4.67 mg / kgBB intramuscularly. Blood sampling performed on day 0 and 7 th for lymphocytes CD3+ and lymphocytes CD8+ test. The results showed that the combination of ethanol extract Ficus septica burm. F leaves and Moringa oleifera leaves dose of 1.25 g / kgBB and the dose of 1.75 g / kgBB can enhanched immune system relative small which was not statistically significantly different (p> 0.05). However, a single dose of ethanol extract Moringa oleifera leaves dose of 500 mg/kg have immunostimulatory activity as lymphocytes CD3+ and lymphocytes CD8+ were more effective than a single dose of ethanol extract of Ficus septica Burm. F leaves dose of 750 mg/kgBB.

EFEK ANTI INFLAMASI KITOSAN DARI CANGKANG UDANG PANTAI TRISIK PADA TIKUS MODEL RHEUMATOID ARTHRITIS Hanifah, Nurul; Darmawan, Endang
Pharmaciana Vol 5, No 2 (2015): Pharmaciana
Publisher : Universitas Ahmad Dahlan

This research was conducted to investigate the effect of chitosan as anti-inflammatory in rheumatoid arthritic in reduction of paw edema using plethysmometer. Chitosan was isolated from the shrimp shell on the Trisik Coastal were administered orally on 17-32th day with CMC 0,5%. This research using repeated measure design. To evaluate anti-inflammatory effect of the suspension, an arthritic rats model was developed using Complete Freund`s Adjuvant (CFA) on 1-16th day. In addition, the research was divided into 5 groups (n=6) including normal control groups, positive control groups, negative control groups, 1 group were treated by chitosan suspension at 50 mg/200 gram BW doses and the other group were treated by chitosan suspension at 100 mg/200 gram BW doses. The reduction of paw edema were determined every 3 day after 17th days then analyzed using general linear repeated measure test (p<0,05). The results showed that paw edema of arthritic rats were evidently decreased by chitosan suspension at 100 mg/200 gram BW doses (142,66%) better than chitosan suspensionÂ at 50 mg/200 gram BW doses (117,23%). In conclusion, the chitosan from shrimp shell of Trisik coastal is found to be effective as anti-inflammatory in rheumatoid arthritic rats model.

EFEK EKSTRAK ETANOL GANGGANG HIJAU (Ulva Lactuca L) TERHADAP BERAT BADAN DAN KADAR TRIGLISERIDA TIKUS JANTAN YANG DIBERI DIET LEMAK TINGGI Widyaningsih, Wahyu; Salamah, Nina
Pharmaciana Vol 5, No 2 (2015): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Previous studies showed the potential of melatonin of green algae ( Ulva lactuca L ) to reduce the risk of coronary heart disease with the activity of antihiperlipidemia. Obesity and hiperlipidemia were the risk factor of degenerative diseases such as heart disease. This research aims was explore the effect of ethanol extract of green algae against weight, consumption of rat feed test white male rat were given high fat diet . Research was started with extraction green algae with ethanol 96 % to obtained concentrated extract. The extract was tested to wistar rats age of 2 months. Animals test divided into 6 group. Group I was control group, treated with high fat diet of lard 2 ml / 200g BW, of group II given high fat diet and simvastatin, group III, IV and V given high fat diet and green algae extract doses 50 mg/ Kg BW, 100 mg/Kg BW and 200 mg/ Kg BW. Group VI is the control group without diet fat high. Treatment was conducted over 28 days. Measuring normal of his weight every five day for 28 days and in measuring consumption feed with measure weight feed the rest of feed early 20 g. The difference of data weight rats per 5 days and consumption fodder for 28 days counted area under curve ( AUC ) from curves time versus weight. The measurement of triglycerides levels. The result showed the high fat diet with lard 2 ml / 200g BW for 28 days reduce weight and consumption feed mice in a significantly than control without high fat diet. The treatment with extract ethanol dose of 50 , 100 and 200 mg / Kg BW did not reduce weight, feed consumption, triglyceride levelsofÂ mice were given high fat diet.

KUALITAS PELAYANAN FARMASI BERDASARKAN WAKTU PENYELESAIAN RESEP DI RUMAH SAKIT Rusdiana, Nita; Wijayanti, Rahayu; Wahyuni, Sri
Pharmaciana Vol 5, No 2 (2015): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Based on Standard of Pharmaceutical Quality in Hospitals, there are methods are applied to distribute pharmaceuticals. One outpatient care efforts is to obtain medication prescribed by a doctor in a short time. The quality of outpatient pharmacy services as measured by the time of complete prescription at the pharmacy installation hospitals are based on reliability, responsiveness, assurance, empathy and tangibles. The study use cross-sectionalâs method, which is done by January-February in 2015, to analyze pharmacy quality standard and time of complete prescription. The data used in this study are primary data. This study was used sample of 157 respondents for quetioners and 787 outpatients prescriptions. The results showed that the highest satisfaction turn around time is 13 minutes. For the five variables tested showed that the responsiveness had the highest scores of 3.18 and tangibles has the lowest score of 2,53. Conclusion, time of complete prescription less than 13 minutes and supported by quetioners shows the highest variables of responsiveness at 3,29 are agreed that time to wait is not too long.

HUBUNGAN JUMLAH OBAT YANG DIRESEPKAN DENGAN POTENSIAL PENGGUNAAN OBAT YANG TIDAK TEPAT PADA PASIEN PENYAKIT GINJAL KRONIS DI RS PKU MUHAMMADIYAH YOGYAKARTA Mulyani, Evi; Darmawan, Endang; Mustofa, Mustofa
Pharmaciana Vol 5, No 2 (2015): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Age-related decrease of physiological function caused some healt problem in elderly, so the problem of treatment in the elderly is also not uncommon found as polypharmacy and Potentially Inappropriate medication (PIMs). The purpose of this study to determine the relationship of the number of drug prescribed with PIMs in elderly patients with CKD in PKU Muhammadiyah Yogyakarta Hospital. PIMs identification by STOPP criteria, while the number of drugs prescribed seen by drugs control books. To assess the patients medical history by interviews and search records. Patient characteristics were analyzed descriptively, correlations between variables were analyzed with chi square test. From 53 samples, PIMs identified 17% and average one sample got one PIMs, while of the 410 drugs that prescribed average patient receivingÂ 8 drugs (> 6). Bivariate test results showed that no significant relationship between the number of drug prescribed with PIMs.

VALIDASI ST EUROPEAN QUALITY OF LIFE-5 DIMENSIONS (EQ-5D) VERSI INDONESIA PADA PASIEN HIPERTENSI DI PUSKESMAS KOTAGEDE II YOGYAKARTA Sari, Andriana; Yuni Lestari, Nidia; Aryani Perwitasari, Dyah
Pharmaciana Vol 5, No 2 (2015): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Hypertension is a major risk factor for the occurrence of deaths from non-communicable diseases in the world. In the World Health Statistics 2012, WHO reported that approximately 51% of deaths from stroke and 45% of coronary heart disease due to hypertension. Patients with obsesitas, hypertension, and diabetes can worsen patientâs quality of life both physically and mental status. This study aims to assess the quality of life by the European Quality of Life-5 Dimensions (EQ-5D) questionnaire. This study aims to determine the validity and reliability of the EQ-5D in Indonesian version as an instrument for measuring the quality of life of patients with hypertension in the Health Center Kotagede II Yogyakarta. The method of this study was descriptive observational. Data were collected using a questionnaire conducted at a particular time. The instrument used in this study is the EQ-5D which has been translated into Indonesian. Affordable population in this study were all patients with hypertension in Health Center Kotagede II Yogyakarta at May to June 2014. The sample in this study are in accordance with the criteria for inclusion and exclusion criteria. Analysis of the validity was constructs validity with Pearson method. Test reliability was Cronbachs alpha coefficient. From the data analysis for 51 patients Hypertension Pearson correlation coefficient obtained results are above 0.30, so it can be concluded instrument EQ-5D questionnaire Indonesian version is valid. Results CornbachsÎ± is 0718 so it can be concluded instrument EQ-5D questionnaire Indonesian version is reliable.

EVALUASI UJI IRITASI DAN UJI SIFAT FISIK SEDIAAN EMULGEL MINYAK ATSIRI BUNGA CENGKEH (Syzigium aromaticum) Sari, Delia Komala; Sugihartini, Nining; Yuwono, Tedjo
Pharmaciana Vol 5, No 2 (2015): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Inflammation is the human bodys response to a tissue damage as indicated by an increase of vascular permeability. One of the natural substances that can be used to treat inflammation is clove oil (MABC). This study aimed to evaluate the physical properties and MABC emulgel irritation test (Syzygium aromaticum). This experimental study was initiated by the emulgel formulation with three kinds of formula, with each formula contains MABC levels of 10% (F1), 12.5% (F2), and 15% (F3). The physical tests for emulgel was done including pH, spreading test and adhesive test and irritation test in guinea pigs using Draize test method. Statistical analysis by t test with a level of confidence 95% was conducted to detect a significant differences between the treatment groups. The emulgel formula with a concentration of 10%, 12.5% and 15% were physically stable, moreover the dispersive power test for each formula showed normal distribution data (p>0.05) and homogeneous (p>0.05), ANOVA test results obtained significantly different results in each formula (p<0.05), whereas the stickiness test results for each formula more than 30 minutes with pH 6. The results of irritation test by using Draize test Â method, indicated that each formula did not show any irritant effect.

PENGARUH PEMAKAIAN KOMBINASI MINYAK JINTEN HITAM (Nigella sativa) dan MADU (Apis mellifera) SEBAGAI ANTI-ACNE SECARA TOPIKAL PADA SUKARELAWAN WANITA Anjani, Baiq Lenysia Puspita; Hati, Ari Sabar; Az-Zahra, Halimah; Rahmawanti, Fitri; Darmawan, Endang
Pharmaciana Vol 5, No 2 (2015): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Acne mostly affects teenagers with prevalence of 85%. Changing habits of cosmetics may affect the incidence of acne vulgaris. Healing acne can use herbal ingredients such as black cumin oil and honey. Black cumin oil effective for treating mild acne vulgaris and moderate acne vulgaris. Honey has property that can kill the bacteria Propionibacterium acnes. Â The purpose of this study is to determine the anti-acne activity in use of black cumin oil and honey combination in 1:1 ratio for 14 days in women. This study included experimental study with pre-post treatment study design. There are 2 groups, control group (six women volunteer) and treatment group (six women volunteer). For 14 days, control group use chemical drugs anti-acne, while treatment group use black cumin oil and honey combination in 1:1 ratio. Analysis of data used independent sample t-test with confidence interval 95%. The results show that treatment group of women who use black cumin oil and honey combination in 1:1 ratio for 14 days compared with the control group of women there is no difference in reducing the number of parameters black blackheads, white blackheads, papules, pustules, hyperpigmentation, erythema, pruritis, xerosis, desquamation, and sunburn with a value of p> 0.05. The conclusion of this study is the use black cumin oil and honey combination in 1:1 ratio for 14 days has effect as Â anti-acne in women, but statistically not significant.Â

PENGARUH KITOSAN DARI CANGKANG UDANG TERHADAP RED BLOOD CELL, HEMOGLOBIN, DAN TROMBOSIT PADA MODEL RHEUMATOID ARTHRITIS YANG DIINDUKSI CFA Sah Putra, Suyandra; Darmawan, Endang
Pharmaciana Vol 5, No 2 (2015): Pharmaciana
Publisher : Universitas Ahmad Dahlan

The research was conducted the effect of chitosan on rats blood alteration that induced arthtritis. In addition, the research used pre-post test group control design. than used Â was divided into groups (n=6) including normal groups, positive control, negatif control, and Â groups were treated byÂ khitosan at varian 50 mg/200gBB and 100 mg/200gBB doses. Adjuvant-induced was developed using complete Freundâs Adjuvant on 1st day, than 17-47th days after treated given appropriate their groups. To evaluate did blodd counter on 0, 16th,and 47th days after treated with otomatic optic dan electronic resisten method. Than analyzed using ANOVA test and paired t-test (p<0,05). Result of the research is Chitosan 50 mg/200gBW fit to reduce of eritrocid 6,1% (p<0,05), hemoglobin 7,77% (p<0,05) and PLCR 35,29% (p<0,05), meanwhile of Chitosan 100 mg/200gBW fit to reduce of trombocyte 40,49% (p>0,05) and PLCR 35,66% (p<0,05). In additional research, khitosan 50 mg/200gBW fit to complete blood of the rheumatoid arthritic mouse well.

PENGEMBANGAN PREPARASI NANOPARTIKEL THYMOQUINONE-KITOSAN DENGAN METODE KOSOLVEN MENGGUNAKAN ISOPROPIL ALKOHOL Binarjo, Annas; Yuwono, Tedjo; Priyanti, Renny
Pharmaciana Vol 5, No 2 (2015): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Thymoquinone, an active compound isolated from black cumin seeds (Nigella sativa L.), has pharmacological activity as anticancer, antiinflammatory, and immunomodulator. This compound has a volatile nature, easily oxidized, and low melting point, leading to difficulties in tablet formulation. Moreover, its low solubility in water leading to low bioavailability. Therefore, it is necessary to develop nanoparticle drug delivery systems to solve these problems. Chitosan-thymoquinone nanoparticles can be formed using sodium tripolyphosphate as cross linker by cosolven method. Chitosan solution in acetate buffer pH 4 was added to thymoquinone solution in 50%, 75%, 100% isopropyl alcohol, than sodium tripoliphosphate solution in water was added slowly in a gently stirrer.Â The nanoparticle produced was characterized in its loading capacity (LC), particle morphology, particle size, and zeta potential, as well as the loading efficiency (LE) of nanoparticle. Factorial Design Optimization resulted that the best condistion is achieved by 75% isopropyl alcohol using thymoquinone level of 10 mg/mL and chitosan level of 10 mg/mL. In this condition, the nanoparticle has LC of 8.71%, LE of 76.29%, 609.8 nm in diameter and zeta potential of 137.9 mV. It can be concluded that isopropyl alcohol can help the formation of nanoparticles thymoquinone. The particle size and zeta potential is too big, therefore it is craved to modify the process by variation in thymoquinone, chitosan, and sodium tripoliphosphat concentration.

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Jl. Prof. Dr. Soepomo, S.H., Janturan, Warungboto, Umbulharjo, Yogyakarta, Indonesia Kode pos 55164

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Home Page

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Contact Name Muhammad Syahrir

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Journal Mail Official nurkhasanah@pharm.uad.ac.id

Editorial Address Jl. Prof. Dr. Soepomo, S.H., Janturan, Warungboto, Umbulharjo, Yogyakarta, Indonesia Kode pos 55164

Location Kota yogyakarta, Daerah istimewa yogyakarta INDONESIA

Abstract

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Contact Name
Muhammad Syahrir

Contact Email
m.syahrir7406@unm.ac.id

Phone
-

Journal Mail Official
nurkhasanah@pharm.uad.ac.id

Editorial Address
Jl. Prof. Dr. Soepomo, S.H., Janturan, Warungboto, Umbulharjo, Yogyakarta, Indonesia Kode pos 55164

Location
Kota yogyakarta,

Daerah istimewa yogyakarta

INDONESIA