Pharmaciana: Jurnal Kefarmasian
Pharmaciana is a scientific journal published by the University of Ahmad Dahlan worked closely with Ikatan Apoteker Indonesia (IAI). Pharmaciana published three times a year, namely March, July and November. with ISSN 2088-4559 and e-ISSN 2477-0256. The article published in the Journal Pharmaciana selected by editors and reviewed by the reviewer. Articles published in Pharmaciana must not be published in other journals or have been previously published. Pharmaciana is indexed in google scholar, ACI (Asean Citation Index), Dimension (Crossreff), Garuda, Sinta, Sherpa Romeo, Index Copernicus International, DOAJ, and BASE. Pharmaciana is accredited by DIKTI (DGHE) of Indonesia No. 105/E/KPT/2022 April 07, 2022
Articles
15 Documents
Search results for
, issue
"Vol 11, No 1 (2021): Pharmaciana"
:
15 Documents
clear
<![CDATA[Effect of virgin coconut oil (VCO) on the physical stability of sweet potato leaf extract (Ipomoea batatas (L.) Lam) creams and antibacterial activity test against Staphylococcus aureus ATCC 25923 ]]>
<![CDATA[Mauritz Pandapotan Marpaung]]>;
<![CDATA[Dani Prasetyo]]>
<![CDATA[ Pharmaciana Vol 11, No 1 (2021): Pharmaciana ]]>
Publisher : <![CDATA[Universitas Ahmad Dahlan ]]>
Show Abstract
|
Download Original
|
Original Source
|
Check in Google Scholar
|
Full PDF (471.87 KB)
|
DOI: 10.12928/pharmaciana.v11i1.18575
<![CDATA[VCO (virgin coconut oil) has benefits for skin health such as softening the skin, maintaining skin health, and protecting the skin from radiation and free radicals. VCO as one of the raw materials for making cream preparations can affect its physical stability. This study aimed to analyze the effect of VCO on the physical stability of sweet potato leaf extract creams and antibacterial activity test against Staphylococcus aureus ATCC 25923. The creams were made with five formulas namely base, extract cream 2%, and VCO 1%, 3%, 5% added to the extract cream 2% respectively. Physical stability test included storage for six weeks at room temperature. Stability parameters were organoleptic observation, homogeneity, pH, spreadability, adhesivity, and cream type. Statistical analysis was carried out with the Anova and Kruskal Wallis tests. The organoleptic test results of the cream extract showed a distinctive odor, green color, with semisolid and homogeneous texture. Increasing the concentration of VCO will increase the spreadability of extract cream but did not affect pH and adhesion. The conclusion of this study was that extract cream 2% without the addition of VCO was the most stable cream formulation. Besides that, all the cream formulas did not show antibacterial activity against Staphylococcus aureus ATCC 25923.]]>
<![CDATA[Booklet handout to improve glycemic control in type-2-DM patients and comparison with other models ]]>
<![CDATA[Daniek Viviandhari]]>;
<![CDATA[Nora Wulandari]]>;
<![CDATA[Nur Rahmi]]>
<![CDATA[ Pharmaciana Vol 11, No 1 (2021): Pharmaciana ]]>
Publisher : <![CDATA[Universitas Ahmad Dahlan ]]>
Show Abstract
|
Download Original
|
Original Source
|
Check in Google Scholar
|
Full PDF (103.389 KB)
|
DOI: 10.12928/pharmaciana.v11i1.17511
<![CDATA[Non-adherence is still a major issue in the management of diabetes in Indonesia which leads to complication problems. Medication adherence in diabetes mellitus is related to better glycemic control, better control of risk factors, lower risk of hospitalization, lower health care cost, and lower risk of mortality. Many educational models are applied to achieve the patient's glycemic control. There were two research purposes in this study. The first one was to determine the booklet handout's effectiveness in improving glycemic control in type-2 diabetes mellitus patients in Malaka Jaya Primary Healthcare Centre, Jakarta. The second aim was to compare two different educational models, which were done simultaneously at Pondok Kelapa Primary Healthcare Centre and Duren Sawit Primary Healthcare Centre. A quasi-experimental study design was applied in these prospective studies. A total of 30 patients met the inclusion criteria. The intervention was a booklet handout that was given and presented to the respondent once every month for three months. The parameter used was the A1C (glycated hemoglobin). For patients exposed to booklet handout, 20.0% of them had the A1C level <6.5% initially, then the A1C level <6.5% significantly increased to 73.34% (p=0.005). For patients who were given public counseling, the number of respondents who had the A1C level <6.5% was 16.7%, then the A1C percentage rose to 76.7% (p=0.005). Meanwhile, for patients who were educated with video, the A1C level <6.5% was 6.67% initially, then the A1C level <6.5% increased significantly to 90.0% (p=0.005) in 12 weeks after the intervention. Either booklet handout, public counseling, or video are effective to improve glycemic control in type-2 diabetes mellitus patients.    ]]>
<![CDATA[Gastroprotective effect of Canna edulis Ker. ethanolic extract in piroxicam-induced rats ]]>
<![CDATA[Dara Pranidya Tilarso]]>;
<![CDATA[Moch. Saiful Bachri]]>;
<![CDATA[Wahyu Widyaningsih]]>
<![CDATA[ Pharmaciana Vol 11, No 1 (2021): Pharmaciana ]]>
Publisher : <![CDATA[Universitas Ahmad Dahlan ]]>
Show Abstract
|
Download Original
|
Original Source
|
Check in Google Scholar
|
Full PDF (670.027 KB)
|
DOI: 10.12928/pharmaciana.v11i1.18063
<![CDATA[Medications derived from plants and pure natural ingredients have far lower side effects and risks than synthetic drugs. One side effect of piroxicam is irritation of the digestive tract. One of the therapeutic preventions to minimize peptic ulcers was utilizing Canna edulis Ker. This study aims to prove that ethanolic extract of Canna edulis Ker. can be used as an alternative to prevent piroxicam-induced peptic ulcers based on ulcer index parameters and the protection ratio. The rats were divided randomly into 6 groups consisting of 5 rats. The normal group was given food and water. The negative control group was given 0.5% CMC-Na. The extract groups were given various doses of ethanolic extract of Canna edulis Ker. (50, 100, and 200 mg/kg BW). The positive control was given sucralfate at 360 mg/kg BW dose. Rats were treated orally for 14 days. One hour after the treatment on the 14th day, all groups except group I were orally administered with piroxicam dissolved in 0.5% CMC-Na at 1.8 mg/kg BW dose. Twenty-four hours later, animals were sacrificed, dissected, and their stomach organs were removed to analyze its number of ulcers. Ulcer observation was formed by giving a score and protection ratio. The mean ulcer index value was 0.33±0.58 for 50 mg/kg BW and 100 mg/kg BW ethanol extract treatment groups, while the 200 mg/kg BW group showed 0.67±0.58. The protection ratio was 83.33±28.87 in 50 mg/kg BW and 100 mg/kg BW treatment groups, while  66.67±28.87 was shown in the 200mg/kg BW group. Canna edulis Ker. ethanolic extract has the gastroprotective ability by decreasing the index of gastric ulcers and increasing the protection ratio to the stomach of piroxicam-induced rats.]]>
<![CDATA[The protective effect of Phyllanthus emblica Linn. extract against doxorubicin-induced hepatotoxicity in rats ]]>
<![CDATA[Eka Susilawati]]>;
<![CDATA[I Nyoman Ehrich Lister]]>;
<![CDATA[Edy Fachrial]]>
<![CDATA[ Pharmaciana Vol 11, No 1 (2021): Pharmaciana ]]>
Publisher : <![CDATA[Universitas Ahmad Dahlan ]]>
Show Abstract
|
Download Original
|
Original Source
|
Check in Google Scholar
|
Full PDF (315.178 KB)
|
DOI: 10.12928/pharmaciana.v11i1.18888
<![CDATA[Recently many researches have been carried out on Malacca fruit extract and its potential protective effect on in vivo organ toxicity. However, there is still no research on the protective effect of Malacca (Phyllanthus emblica L.) fruit extract on induced hepatotoxicity of anticancer drugs, especially doxorubicin in rats. The objective of this study is to determine the potential protective effect of ethanol extract of Malacca fruit (P. emblica L.) against doxorubicin-induced hepatotoxicity in rats. A preliminary phytochemical test was done followed by administration extract into doxorubicin-induced rats. Histological studies were carried out to observe the effect of the extract on liver tissue. Phytochemical test results show that the ethanol extract of Malacca fruit contains flavonoids, phenols, tannins, triterpenoids, terpenoids, and alkaloids. The increasing value of ALT and ALP of doxorubicin-induced liver tissue proved the toxicity in liver tissue caused by doxorubicin. The ethanol extract of P. emblica L. at dosage 200 mg/kg BW and dosage 400 mg/kg BW on doxorubicin-induced rats were successfully played as an antioxidant to decrease the ALT and ALPvalues and improve liver tissue doxorubicin-induced by normal hepatocytes more dominant than lysis and less mark of bleeding and congestion of blood vessels.]]>
<![CDATA[Formulation optimization and antioxidant test for Self-nano emulsifying drug delivery system of soursop leaves (Annona muricata L.) chloroform extract using candlenut oil as oil phase ]]>
<![CDATA[Anif Nur Artanti]]>;
<![CDATA[Anggraini Febriyanty]]>;
<![CDATA[Fea Prihapsara]]>;
<![CDATA[Dian Eka Ermawati]]>
<![CDATA[ Pharmaciana Vol 11, No 1 (2021): Pharmaciana ]]>
Publisher : <![CDATA[Universitas Ahmad Dahlan ]]>
Show Abstract
|
Download Original
|
Original Source
|
Check in Google Scholar
|
Full PDF (226.035 KB)
|
DOI: 10.12928/pharmaciana.v11i1.17805
<![CDATA[Soursop leaves (Annona muricata L.) chloroform extract has an anticancer agent that can be developed for traditional medicine preparation, even though the extract's solubility is low in the water. This study aims to generate new soursop leaves chloroform extract in the Self-Nano Emulsifying Drug Delivery System (SNEDDS). The expected result is that the solubility increases so that the drug delivery system is more effective. The extraction process of soursop leaves uses the percolation method with chloroform as a solvent. It used tween 80 and cremophore E.L. as surfactant, propylene glycol as a cosurfactant, and candlenut oil as a carrier, to make the SNEDDS formulation. Then performed a comparison between the optimal parameters for the physical properties of the SNEDDS formulation with the predictive Simplex Lattice Design (SLD) formulation with the students' t-test statistical analysis [p> 0.05]. Then carried out several tests such as loading dosage extractability, accelerated stability test, particle size, and zeta potential. Furthermore, the antioxidant test was carried out using the DPPH reagent. The optimum composition of candlenut oil, propylene glycol, a mixture of tween 80, and cremophor E.L. based on SLD is 12%: 22%: 66%, respectively. The SNEDDS optimum formulation for chloroform extract of soursop leaves produces a stable nanoemulsion, homogenous. It has a transmittance value of 90.58% ± 0.151, emulsification time of 59.44 ± 1.763 seconds, and a value of separation phase 1. The physical formulation test results showed no significant difference between observations with predictive design expert software. SNEDDS can produce 25.0 mg of soursop chloroform extract with particle size 411.4 nm, polydispersion index 0.482, and zeta potential 34.2 mV. IC50 value in 36.28 ppm indicated the antioxidant potential of the SNEDDS formulation for chloroform extract of soursop leaves is high.]]>
<![CDATA[Effect of carboxymethylcellulose sodium addition as stabilizer for physicochemical characteristic of purple sweet potato fortified yogurt (Ipomoea batatas L.) ]]>
<![CDATA[Uci Ary Lantika]]>;
<![CDATA[Fitrianti Darusman]]>;
<![CDATA[Widad Aghnia Shalannandia]]>;
<![CDATA[Astrid Feinisa Khairani]]>
<![CDATA[ Pharmaciana Vol 11, No 1 (2021): Pharmaciana ]]>
Publisher : <![CDATA[Universitas Ahmad Dahlan ]]>
Show Abstract
|
Download Original
|
Original Source
|
Check in Google Scholar
|
Full PDF (428.381 KB)
|
DOI: 10.12928/pharmaciana.v11i1.18088
<![CDATA[The yoghurt consisted of low-fat milk, three bacterial strains starter, which included: L. bulgaricus ATCC 11842, L. plantarum ATCC 8014, and B. longum (1:1:1); purple sweet potato puree (Ipomoea batatas, L.) and carboxymethylcellulose sodium with the concentration of 0.6%, 1.2%, and 1.8%. Purple sweet potato fortification in yogurt can prevent hypercholesterolemic conditions because it inhibits lipid and sugar absorption in the intestine. Unfortunately, there is one shortcoming in the production of yogurt which affects the final product quality. This shortcoming is in the decrease in the air holding capacity (whey off) during the production due to the pH level within the isoelectric point of casein. This causes precipitation and phase separation. This study will add a stabilizer to the formula to overcome it. The stabilizer used is carboxymethylcellulose sodium, which is semi-synthetic water-soluble ester polymer cellulose. This study aimed to determine the optimal concentration of carboxymethylcellulose sodium and its effect on purple sweet potato yogurt's physicochemical and organoleptic properties. The product quality evaluations were on organoleptic evaluation, density, viscosity, and pH level. Centrifugation and freeze-thaw tests were also performed to evaluate product stability. The results showed that carboxymethylcellulose sodium could maintain the stability of purple sweet potato yogurt by binding the air content, increasing consistency, and smoothing the texture even though it did not affect the freezing point of the product. This study gave the best results for purple sweet potato yogurt with 1.2% carboxymethylcellulose sodium concentration.]]>
<![CDATA[Comparison between clinic and home measurements of blood pressure, total cholesterol, blood sugar to identify 10-year atherosclerotic cardiovascular disease risk score ]]>
<![CDATA[Putri Ani Sunjaya]]>;
<![CDATA[Agatha Nensida Venary]]>;
<![CDATA[Ruth Estika Ave Haryono]]>;
<![CDATA[Rita Suhadi]]>
<![CDATA[ Pharmaciana Vol 11, No 1 (2021): Pharmaciana ]]>
Publisher : <![CDATA[Universitas Ahmad Dahlan ]]>
Show Abstract
|
Download Original
|
Original Source
|
Check in Google Scholar
|
Full PDF (509.478 KB)
|
DOI: 10.12928/pharmaciana.v11i1.13731
<![CDATA[The clinical guideline recommends home monitoring for hypertension, diabetes, and hyperlipidemia maintenance therapy. The study aimed to compare the 10-year atherosclerotic cardiovascular disease (ASCVD) risk calculated using systolic blood pressure, fasting total-cholesterol, and fasting blood sugar measured at the clinic and home. This analytical cross-sectional study was done in population from villages in Sleman District, Yogyakarta. The subjects were selected purposively with the criteria of 40-79 years old and signing the informed consent. The home-measured systolic blood pressure was monitored with a digital sphygmomanometer and peripheral finger-stick methods for cholesterol and blood sugar. On the same occasion, the clinic measurements were monitored with a mercury sphygmomanometer for systolic blood pressure, and with venous plasma analyzed in the laboratory for cholesterol and blood glucose. Measurements between methods were compared with paired T-tests. The subjects (n=171) had a mean age of 52.6 (8.1) years; 21.6% were male. The systolic blood pressure, total cholesterol, and blood glucose from clinic and home measurement were 130.0 (21.1) mmHg and 137.6 (22.4) mmHg (p<0.001); 202.8 (32.8) mg/dl and 205.2 (44.8) mg/dl (p= 0.44); and 98.5 (42.9) mg/dl and 91.9 (34.6) mg/dl (p<0.001) respectively. The average ASCVD risks of the clinic and home measurements were 6.4 (6.2)% and 7.1 (6.9)% (p<0.001); however, both methods had the same ASCVD risk category at borderline risk (5-<7.5%). Conclusion: The ASCVD risk scores calculated using clinic and home measurements were statistically different.]]>
<![CDATA[The effect of propylene glycol and polyethylene glycol 400 on physicochemical properties of peel off mask of nanosilver using bioreductor Sweet Orange Peels (Citrus sinensis L. Osbeck) ]]>
<![CDATA[Dian Eka Ermawati]]>;
<![CDATA[Fridha Angelina Pamuji]]>;
<![CDATA[Adi Yugatama]]>
<![CDATA[ Pharmaciana Vol 11, No 1 (2021): Pharmaciana ]]>
Publisher : <![CDATA[Universitas Ahmad Dahlan ]]>
Show Abstract
|
Download Original
|
Original Source
|
Check in Google Scholar
|
Full PDF (454.473 KB)
|
DOI: 10.12928/pharmaciana.v11i1.19663
<![CDATA[Nanosilver (AgNPs) can be synthesized using plant extracts that safe, simple, and environmentally friendly. Sweet orange contains flavonoids and citric acid, which can be a bioreductor and capping agent in silver biosynthesis to increase antimicrobial activity. AgNPs are then dispersed in a gel for acne treatment through a peel-off mask preparation. Humectants provide moisture, prevent skin irritation and regulate the viscosity of the preparation. Propylene Glycol (PG) and Polyethylene Glycol 400 (PEG 400) are humectants combined to obtain good physicochemical properties of the preparation. This study aims to determine the character of AgNPs and the effect of humectant combinations on the physicochemical properties of peel-off mask preparations. AgNPs characterization was performed using UV-VIS Spectrophotometry, Particle Size Analysis, and Scanning Electron Microscope. The PG-PEG 400 combinations are F1 (0: 100%); F2 (25%: 75%); F3 (50%: 50%); F4 (75%: 25%) and F5 (100%: 0). The physical-chemical test for 28 days included organoleptic, viscosity, dry time, and pH. The biosynthesis results produced AgNPs with maximum absorption of nanoparticles at 435 nm, rod morphological shapes measuring 106 ± 10.6 nm, and PI 0.26 ± 0.06. Statistical analysis showed that the PG-PEG 400 combination significantly affected the viscosity, dispersibility, and dry time of the preparation but affected nothing to pH. The combination of PG-PEG 400 decreased the viscosity and increased the dispersibility of peel-off mask preparation. The higher concentration of propylene glycol caused the dry time of preparation to become longer. Formulas with PG-PEG 400 combination of 25%: 75% and 75%: 25% meet the requirements of viscosity, dispersibility, dry time, and pH and not significant changes during 28 days of storage at room temperature.]]>
<![CDATA[Synthesis and virtual screening of bis-(4-(tert-butyl)-N-(methylcarbamothioyl) benzamide)-Iron (III) complex as an anticancer candidate ]]>
<![CDATA[Ruswanto Ruswanto]]>;
<![CDATA[Winda Trisna Wulandari]]>;
<![CDATA[Richa Mardianingrum]]>;
<![CDATA[Indah Cantika]]>
<![CDATA[ Pharmaciana Vol 11, No 1 (2021): Pharmaciana ]]>
Publisher : <![CDATA[Universitas Ahmad Dahlan ]]>
Show Abstract
|
Download Original
|
Original Source
|
Check in Google Scholar
|
Full PDF (613.942 KB)
|
DOI: 10.12928/pharmaciana.v11i1.17837
<![CDATA[Thiourea derivatives were much used in drug discovery and drug-making, such as for an anticancer. The formation of drug complexes can increase lipophilicity through chelation formation, and the drug action is significantly upward due to the effective permeability to the center. In another study, the alteration of the compound becomes the complex with metal will grow in its activity so recently we have synthesized the Bis-(4-(Tert-Butyl)-N-(Methylcarbamothioyl) Benzamide)-Iron (III) complex. The synthesis of Fe (III) metal with the 4-(Tert-Butyl)-N-(Methylcarbamothioyl) Benzamide in ethanol by reflux at 75oC for 7 hours. Hot Stage Microscopy, UV-Visible Spectrophotometry Infrared Spectrophotometry, and Massa Spectrophotometry were used to characterize the complex. This study concerns representing, inferring, and predicting pharmacokinetics and toxicity and molecular docking complexes. The complex weight was 0.29469 g. Its purity has been tested using the melting point determination and has obtained its range was 113o-115oC. The Characteristics of Bis-(4-(Tert-Butyl)-N-(Methylcarbamothioyl) Benzamide)-Iron(III) complex have a maximum wavelength of 260,0 nm and provide absorption of Fe-O vibrations at wavenumbers 478,2 cm-1and 588 cm-1, and the m/z complex of spectrophotometry mass was 559,31. The molecular docking process was performed using AutodockTools-1.5.6 software. It showed that Bis-(4-(Tert-Butyl)-N-(Methylcarbamo-thioyl)Benzamide)-Iron(III) complex could interact with ribonucleotide reductase enzyme, and it has better interaction than the 4-(Tert-Butyl)-N-(Methylcarbamothioyl)Benzamide with the binding affinity energy (ΔG)of  -8,52 kcal/mole and the constant inhibition (Ki ) of 568,55 nM.]]>
<![CDATA[Ointment formulation of snakehead fish (Channa striata) Extract with variations of CMC-Na and carbopol ]]>
<![CDATA[Mohamad Andrie]]>;
<![CDATA[Wintari Taurina]]>
<![CDATA[ Pharmaciana Vol 11, No 1 (2021): Pharmaciana ]]>
Publisher : <![CDATA[Universitas Ahmad Dahlan ]]>
Show Abstract
|
Download Original
|
Original Source
|
Check in Google Scholar
|
Full PDF (303.595 KB)
|
DOI: 10.12928/pharmaciana.v11i1.18385
<![CDATA[Â Snakehead fish (Channa striata) and kelulut honey (Trigona sp.) have the potential to accelerate the wound-healing process. These natural ingredients are formulated in the form of ointment because ointment is an external medicine that is easy to apply and has long contact with the skin. Previous research has shown that the snakehead fish extract ointment undergoes phase separation, so it needs a material that can bind the snakehead fish extract and kelulut honey as the active substances in the preparation. This study aimed to determine the effect of variations in the concentration of CMC-Na (3%, 4.5%, 6%) and Carbopol (0.5%, 1%, 2%) as a binder on the ointment physical properties and to determine the best snakehead fish (Channa striata) extract ointment formulation. The ointment of snakehead fish extract was tested for organoleptic, homogeneity, spreadability, and adhesion. The test results were analyzed by One Way ANOVA with a confidence level of 95%. The results showed that the higher the concentrations of CMC-Na and Carbopol used, the greater the adhesive power and the lower the spreadability. Ointment with Carbopol has a wider spreadability and a softer consistency than ointment with CMC-Na. The best formulation is shown by the Carbopol 0.5% (F4) formula, where the average spreadability with a load of 150 g is 5.09 cm and the average adhesion is 229 seconds.]]>
