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Pharmaciana: Jurnal Kefarmasian
Published by Universitas Ahmad Dahlan
ISSN : 20884559     EISSN : 24770256     DOI : 10.12928
Core Subject : Health,
Medicine & Pharmacology
Pharmaciana is a scientific journal published by the University of Ahmad Dahlan worked closely with Ikatan Apoteker Indonesia (IAI). Pharmaciana published three times a year, namely March, July and November. with ISSN 2088-4559 and e-ISSN 2477-0256. The article published in the Journal Pharmaciana selected by editors and reviewed by the reviewer. Articles published in Pharmaciana must not be published in other journals or have been previously published. Pharmaciana is indexed in google scholar, ACI (Asean Citation Index), Dimension (Crossreff), Garuda, Sinta, Sherpa Romeo, Index Copernicus International, DOAJ, and BASE. Pharmaciana is accredited by DIKTI (DGHE) of Indonesia No. 105/E/KPT/2022 April 07, 2022
Arjuna Subject : Kimia(semua kategori) - Kimia (Lain-Lain)
Articles 36 Documents
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Search results for , issue "Vol 8, No 1 (2018): Pharmaciana" : 36 Documents clear
The formulation of probiotic Lactobacillus acidophilus granule with acacia and sodium alginate as binding agents Ari Widayanti; Lusi Susanah; Priyo Wahyudi
Pharmaciana Vol 8, No 1 (2018): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (140.288 KB) | DOI: 10.12928/pharmaciana.v8i1.9152

Abstract

Probiotics are living microorganisms that can have a positive impact on health when consumed in adequate amounts. This research aimed to determine the effect of different binders on the viability of Lactobacillus acidophilus, a member of Lactic Acid Bacteria (LAB). The probiotic granules were prepared with wet granulation method using mannitol as the filling ingredient. Formulas I-III used acacia as a binder (3%, 4%, and 5%), while Formulas IV-VI used sodium alginate (1%, 1.5%, and 2%). The probiotic granules produced from all formulas were evaluated for flow time, the angle of repose, compressibility, and LAB viability. The LAB viability test results showed that all of the six formulas met the probiotic requirements, i.e., at least 107 CFUs (Colony Forming Units) per gram. The viable LAB in Formulas I-VI were 3.94x107, 4.4x107, 2.7x107, 2.6x107, 3.5x107, and 2.3x107 CFU/g, respectively. The data were analyzed by comparing the average values of the One-Sample T-Test results, followed by Mann-Whitney test. The results revealed that each formula had different capacity in maintaining the viability of Lactobacillus acidophilus with different binders (i.e., acacia and sodium alginate) as a probiotic product. Formula II (4% of acacia) produced probiotic granules that met the requirements of compressibility and the angle of repose. However, its granular flow time exceeded the standard.
Formulation and test activities of hair tonic with a combination of the aqueous extracts of aloe vera ( Aloe vera L.) and licorice (Glycyrrhiza glabra L.) Sulistiorini Indriaty; Teti Indrawati; Shelly Taurhesia
Pharmaciana Vol 8, No 1 (2018): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (53.953 KB) | DOI: 10.12928/pharmaciana.v8i1.8877

Abstract

Aloe vera contains lignin, folic acid, vitamin A, and 20 types of amino acids, while Glycyrrhiza glabra L. contains glycyrrhizin, steroids, and beta-glycyrrhetinic acid that benefit for hair health. This research aimed to produce hair tonic with the best activity from the combination of aloe vera and licorice extract. The phytochemicals in the aqueous extract of licorice and Aloe vera were screened. The hair tonic was then prepared with 3 formulas using 7.5% Aloe vera extract and 2.5% licorice extract, as well as 96% ethanol with varying percentages, namely 5, 10, and 15%. Afterward, the formulas were tested for their activity as hair fertilizer on 4 white male rabbits for 28 days. The evaluation of hair tonic preparation included organoleptic observation, pH, specific weight, viscosity, and hedonic tests. It measured hair growth rate, the acceleration of hair growth, and hair weight. The results showed that hair tonic containing a mixture of 7.5% of Aloe vera extract, 2.5% of licorice extract, and 96% ethanol with different percentages (i.e., 5, 10, and 15%) created a good hair fertilizer. Hair tonic prepared with 15% of 96% ethanol exhibited an optimum activity. It was characterized by brown color, distinctive odor, homogeneity, a specific weight of 1.0577 g/mL, a viscosity of 2.8479 cP to distilled water, and pH 5.5. Its effectiveness as hair fertilizer was evidenced by a hair growth rate of 2.6617 cm in 28 days, a hair growth acceleration of 0.1635 cm/day, and a hair weight of 0.1854 gram in 28 days.
The relationship between patient satisfaction and effectiveness of insulin-based therapy for type 2 diabetes mellitus at Ulin Regional Public Hospital, Banjarmasin Risya Mulyani; Dedi Hartanto
Pharmaciana Vol 8, No 1 (2018): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (422.09 KB) | DOI: 10.12928/pharmaciana.v8i1.7633

Abstract

Diabetes Mellitus (DM) can cause significant problems to the quality of life as it may increase the risk of complications. Dissatisfaction with therapy also contributes to its low effectiveness. Therapeutic satisfaction has an essential role in DM management, i.e., to optimize the effectiveness of the treatment. It is also believed to affect the decision-making process regarding patients‘ healthrelated issues. A routine assessment of the satisfaction of DM patients is useful for health professionals in identifying the potential problems experienced by those who are in the middle of DM treatment. This study aimed to determine the relationship between patient satisfaction and effectiveness of insulin-based therapy for type 2 DM at Ulin Regional Public Hospital, Banjarmasin. This research is a nonexperimental study with a cross-sectional design. The data were collected prospectively with purposive sampling method from the type 2 DM patients at the Pharmacy Installation of Ulin Regional Public Hospital, Banjarmasin. While the therapeutic satisfaction data were obtained using the Patient Satisfaction with Insulin Therapy (PSIT) questionnaire, the effectiveness of the therapy was identified by examining the HbA1c values. Fifty-six (56) respondents participated and filled in the questionnaire, and the answers were processed with bivariate analysis, namely the chi-square test. The results showed that the respondents‘ satisfaction with the treatments was mostly on a medium level according to 33 patients (58.9%). However, only 3.6% respondents found the therapy effective (HbA1c <6.5%). The remaining 96.4% thought that it was less effective in controlling diabetes. Based on the statistical analysis results, there is a significantly positive relationship between patient satisfaction and HbA1c value ([r= 0.828]; [p= 0.000]). There is also a significant positive relationship between patient satisfaction and the effectiveness of therapy in patients with type 2 diabetes at the Pharmacy Installation of Ulin Regional Public Hospital, Banjarmasin.
Chemometrics-assisted spectrophotometry for simultaneous determination of sodium benzoate and citric acid in beverage products Ganjar Wahyu Rahardian; Sausa Monica; Hendri Wasito; Sri Sutji Susilowati
Pharmaciana Vol 8, No 1 (2018): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (196.299 KB) | DOI: 10.12928/pharmaciana.v8i1.6766

Abstract

The development and validation of chemometrics-assisted spectrophotometry have been successfully performed for determination of sodium benzoate and citric acid that have overlapping of ultra violet absorption spectra. The study aimed to develop, validate, and apply spectrophotometric method with chemometrics approach for determination of both compounds in beverage products simultaneously. The analytical method was performed by making a calibration model using 16 training sets and 10 test sets of mixed solution followed by absorbance measurenment at wavelength of 190 nm up to 400 nm. In addition, the absorbance data was processed by multivariate calibration models of principal component regression (PCR) and partial least square-1 (PLS-1) and validated internally and externally to obtain optimum model. Validation of analytical methods was done by evaluating some parameters such as linearity and ranges, accuracy, precision, detection limits and quantification limits. The results showed that the optimum wavelength was 235 nm to 250 nm for sodium benzoate and 220 nm to 240 nm for citric acid with the selected optimum principal components (PCs) value were 6 (PCR) and 4 (PLS-1) for sodium benzoate and PCs 2 (PCR and PLS-1) for citric acid. The parameters of the analytical method validation developed were suitable and the analytical methods could be applied for the determination of the sodium benzoate and citric acid contents simultaneously in the beverage products. 
Detoxification of 1,2-dihydroxy- 4-allylbenzene, a major phenolic compound in Piper betle, through glucuronidation using S9 protein of rat liver (Sprague Dawley) Erryana Martati
Pharmaciana Vol 8, No 1 (2018): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (355.158 KB) | DOI: 10.12928/pharmaciana.v8i1.9194

Abstract

1,2-dihydroxy- 4-allylbenzene (DHAB) is a major compound in Piper betle leaf and also a metabolite of safrole metabolism. Epidemilogic studies showed people who have betel quid chewing habit are related to the incidence of oral submucous fibrosis and/or tumor formation. The aims of this research was to study the detoxification through the glucuronidation of DHAB using S9 protein of male rat liver  (Sprague Dawley) and a co-factor of uridin 5′-diphosphoglucuronide acid (UDPGA). The results showed that glucuronidation of DHAB using S9 protein of rat liver resulted two isomers of glucuronide metabolites due to the availibility of two active hydroxyl groups that one of them can bind glucuronide but not two of hydroxyl at the same time.
Antibacterial activity of two isolated endophytic extracts assosiated with Indonesian mangrove plant Rhizophora mucronata Muhamad Salman Fareza; Nur Amalia Choironi; Harwoko Harwoko; Sunarto Sunarto
Pharmaciana Vol 8, No 1 (2018): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (52.736 KB) | DOI: 10.12928/pharmaciana.v8i1.8878

Abstract

Endophytic fungi are microorganisms reside in the living tissues of the host plant. This fungi can contribute to provide protection to the host from the infection caused by another microorganism. The one reasonable strategy to discover a new antibacterial agent from endophytic fungi are from the plant which lived in special condition such Rhizophora mucronata. The aim of this research is to determine antibacterial activity of the endophytic fungi extracts assosiated with Rhizophora mucronata from Sagara anakan. The isolated endophytic fungi was identified as Neopestalotiopsis sp. and Peniophora lycii using molecular analysis method. The antibacterial activity was carried out by using microdillution method. The antibacterial properties from mycelium extracts showed moderate to low antibacterial activity with Minimum Inhibitory Consentration (MIC) values of 125-500 µg mL-1 against Eshcerichia coli ATCC 25922 and Staphylococcus aureus ATCC 25923 bacteria. The n-hexane extract of both endophytic fungi shows the strongest antibacterial activity against Escherichia coli with MIC values of 125 µg mL-1

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