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Journal of Islamic Pharmacy
Published by Universitas Islam Negeri Maulana Malik Ibrahim Malang
ISSN : 24605182     EISSN : 25276123     DOI : http://dx.doi.org/10.18860/jip
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Immunology & microbiology Medicine & Pharmacology Public Health
Welcome to Journal of Islamic Pharmacy (e-ISSN : 2527-6123) formerly Jurnal Farmasains (p-ISSN : 2460-5182) Department of Pharmacy, Universitas Islam Negeri Maulana Malik Ibrahim Malang, Indonesia. The journal was established in 2015 and online publication was begun in 2016. Since 2016, the journal has been published in English and only receives manuscripts in English.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 10 Documents
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Search results for , issue "Vol 10, No 1 (2025): J. Islamic Pharm." : 10 Documents clear
Informasi Obat Non Etiket pada Pasien Hipertensi di Puskesmas Kota Bandar Lampung Isnenia, Isnenia; Fauziyah, Ageng Hasna
Journal of Islamic Pharmacy Vol 10, No 1 (2025): J. Islamic Pharm.
Publisher : Universitas Islam Negeri Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jip.v10i1.32432

Abstract

Etiket sebagai media informasi obat memiliki keterbatasan dalam menampung informasi. Beban kerja yang tinggi menjadi alasan pemberian informasi obat secara lisan tidak adekuat. Hipertensi sebagai penyakit kronis, membutuhkan pengobatan jangka panjang. Ketidakpatuhannya dapat berdampak buruk bagi kualitas hidup pasien. Penelitian ini bertujuan untuk mengetahui media selain etiket yang diperoleh pasien, jenis informasi lisan selain yang ada di etiket, tingkat kepentingan untuk dicantumkannya, dan sumber informasi obat selain dari puskemas. Penelitian dilakukan secara cross-sectional pada 134 pasien hipertensi. Pengumpulan data dilakukan dengan observasi saat pasien memperoleh obat dan wawancara. Hasil yang diperoleh yaitu sebanyak 69,4% responden adalah perempuan, 73% berada pada rentang umur 61-80 tahun, lama menderita hipertensi 1-5 tahun. Media selain etiket berupa kartu kendali kronis dan potongan kertas diperoleh 33,5% responden. Jenis informasi tertulis pada media tersebut adalah nama obat, jumlah obat, tanggal berobat ulang pada kartu kendali kronis, dan waktu minum obat pada potongan kertas. Informasi lisan yang tidak tercantum pada etiket adalah penggunaan rutin di malam hari, pagi hari, dan tanggal berobat ulang. Responden menyatakan tidak perlu menuliskan informasi lisan tersebut. Responden memperoleh informasi obat selain dari puskesmas sebesar 17,2% (kerabat, kader posyandu, dan tenaga kesehatan). Dapat disimpulkan bahwa terdapat media non etiket (kartu kendali dan potongan kertas) sebagai informasi tambahan tertulis dan informasi lisan tidak tertulis pada etiket yang diberikan pada responden. Sebagian kecil responden memperoleh informasi selain dari puskesmas.Labels, as a tool for drug information, have limitations in accommodating comprehensive information. A high workload often leads to the inadequate provision of verbal drug information. Hypertension, being a chronic disease, necessitates long-term treatment. Non-compliance can significantly impact a patient's quality of life. This study aimed to identify media used by patients other than labels, types of verbal information provided beyond what is written on labels, the perceived importance of documenting this information, and sources of drug information other than the health center. This cross-sectional study was conducted on 134 hypertensive patients. Data were collected through observation when patients received drugs and through interviews.The results show that 69.4% of respondents were female, 73% were in the 61-80 age range, and they had suffered from hypertension for 1-5 years. Media other than labels, such as 'kartu kendali kronis' and pieces of paper, were obtained by 33.5% of respondents. The types of information written on these media included the name of the drug, the quantity of the drug, and the date of repeat treatment on the 'kartu kendali kronis', as well as the time to take the drug on the pieces of paper. Verbal information not listed on the labels included routine use at night, in the morning and the date of repeat treatment. Respondents indicated that they did not need to have this verbal information written down. A small percentage of respondents (17.2%) obtained drug information from sources other than the health center, including relatives, integrated health post cadres, and other health workers. In conclusion, non-label media (specifically 'kartu kendali kronis' and pieces of paper) serve as sources of additional written information, and verbal information not written on labels is also provided to respondents. A minority of respondents obtained information from sources other than the health center.
Kualitas Hidup Pasien Parkinson Berdasarkan Jenis Obat yang Digunakan Fatkhiya, Musa Fitri; Jeff, Jamaludin Al; Setiana, Cita; Yaasiin, Muhammad Malik; Haq, M. Fahmi Izzul
Journal of Islamic Pharmacy Vol 10, No 1 (2025): J. Islamic Pharm.
Publisher : Universitas Islam Negeri Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jip.v10i1.28856

Abstract

Parkinson merupakan penyakit neurodegenerative yang memerlukan pengobatan jangka panjang atau bahkan seumur hidup. Dampak yang ditimbulkan dari penyakit Parkinson adalah gangguan pergerakan dan otot seperti tremor, gerakan melambat atau kekakuan otot pada penderita. Terapi farmakologi dan non farmakologi diperlukan untuk meminimalkan gejala. Keberhasilan manajemen dampak dan gejala tersebut dapat mempengaruhi kualitas hidup pasien Parkinson.  Tujuan dilakukan penelitian untuk mengetahui kualitas hidup pada kemampuan aktivitas pasien Parkinson berdasarkan jenis obat yang digunakan. Penelitian ini merupakan penelitian deskriptif observasional dan data diambil secara prospektif dengan mengambil data pasien Parkinson rawat jalan di RSUD dr. M. Ashari dan menyebarkan kuisioner kualitas hidup kepada pasien Parkinson. Teknik sampling menggunakan purposive sampling yang sesuai dengan kriteria inklusi dan eksklusi. Penelitian dianalisis univariat dan bivariate menggunakan SPSS. Hasil penelitian dari 23 sampel menunjukkan karakteristik paling banyak pasien jenis kelamin laki-laki sebesar 70%, dan sebanyak 52% berusia 65 tahun. Sebanyak 33% pasien Parkinson menerima obat Levodopa dan Triheksiphenidil. Pasien Parkinson dengan kemampuan aktivitas berdasarkan jenis pengobatan paling besar pada pemberian Triheksiphenidil dengan aktivitas Baik Sekali sebesar 90%. Kualitas hidup pasien berdasarkan jenis terapi yang digunakan mendapatkan hasil p value = 1  (0,05). Pada penelitian ini dapat disimpulkan bahwa tidak terdapat perbedaan kualitas hidup berdasarkan terapi yang yang digunakan.
Rasionalitas Penggunaan Obat Pada Pasien Diabetes Melitus Tipe II Di Puskesmas Kota Martapura Tahun 2023 Normila, Normila; Soemarie, Yulistia Budianti; Ramadhani, Juwita
Journal of Islamic Pharmacy Vol 10, No 1 (2025): J. Islamic Pharm.
Publisher : Universitas Islam Negeri Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jip.v10i1.32341

Abstract

Diabetes melitus tipe 2 dikatakan sebagai gangguan metabolisme yang umum di dunia, penyakit ini disebabkan oleh rusaknya sekresi insulin oleh sel ẞ pankreas serta ketidakmampuan jaringan tubuh dalam merespon insulin. Tujuan studi ini agar mengetahui rasionalitas pengobatan diabetes melitus tipe 2 pada pasien di Puskesmas  Kota Martapura di Kabupaten Banjar tahun 2023.  Metode yang dimanfaatkan agar studi ini ialah non-eksperimental observasional bersama rancangan studi deskriptif serta pengambilan data secara retrospektif. Sampel penelitian sebanyak 173 dengan menggunakan rekam medis pasien diabetes melitus tipe 2 yang dianalisis kesesuaiannya dengan standar PERKENI 2019 penelitian ini juga menggunakan probability sampling dalam pengambilan sampel.  Hasil penelitian berdasarkan demografi pasien pada jenis kelamin yang paling banyak ialah perempuan, sebanyak 64%, pekerjaan pasien terdapat Ibu rumah tangga 29%, paling tinggi dan rentang umur pasien ditemui 47,89% pada rentang 56-65 tahun. Jumlah penyakit penyerta pasien yang banyak ditemui DM Tipe 2 dengan  Hipertensi 46%.  Hasil evaluasi rasionalitas  ditemukan di Puskesmas Kota Martapura memiliki tepat indikasi (99%) serta  tidak tepat (1%), tepat pasien 100%, tepat obat 100%. Tepat dosis 100%,  cara pemberian obat  sebesar 100%, tepat interval waktu pemberian  98 % tidak tepat 2%, tepat lama pemberian obat sebesar 100% tepat.  
Perbandingan dan Optimasi Metode Pembuatan Kompeten Sel Escherichiae coli, Media dan Suhu Transformasi pET-32-HCR-CTB sebagai Dasar Pengembangan Kandidat Vaksin COVID Poejiani, Soeyati; Megasari, Suci; Yurina, Valentina
Journal of Islamic Pharmacy Vol 10, No 1 (2025): J. Islamic Pharm.
Publisher : Universitas Islam Negeri Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jip.v10i1.31390

Abstract

Vaksinasi merupakan salah satu strategi utama dalam mengatasi pandemi. Saat ini sebagian besar vaksin yang dikembangkan merupakan vaksin berbasis teknologi rekombinan. Protein rekombinan sering menggunakan bakteri Escherichia coli (E. coli) karena mudah dimanipulasi secara genetik dan relatif aman untuk dikembangkan. Teknologi DNA rekombinan menggunakan berbagai jenis plasmid sebagai vektor utama yang memfasilitasi masuknya DNA rekombinan ke dalam bakteri. Plasmid pET-32 merupakan plasmid yang dikembangkan untuk kloning dan ekspresi protein rekombinan pada E. coli. Meskipun metode transformasi plasmid pada bakteri cukup lama dikembangkan, namun sering menemui kendala dalam prosesnya. Penelitian ini bertujuan mengembangkan metode pembuatan sel kompeten dan metode transformasi yang paling efektif. Metode pembuatan sel kompeten dengan menggunakan calcium chloride (CaCl₂) dan dimethyl sulfoxide (DMSO), serta optimasi transformasi gen pET-32-HCR-CTB ke dalam sel kompeten BL21 dilakukan menggunakan kondisi heat shock pada suhu 42°C selama 45 detik dan 60 detik. Hasil penelitian menunjukkan bahwa penggunaan DMSO dalam pembuatan sel kompeten menghasilkan efisiensi transformasi sebesar 3,5 × 10³ CFU/µg. Klon bakteri yang tumbuh setelah proses transformasi kemudian diuji menggunakan PCR, yang mengonfirmasi keberadaan gen pET-32-HCR-CTB. Dengan demikian, variasi metode pembuatan sel kompeten BL21 dan kondisi optimum transformasi yang diperoleh dalam penelitian ini dapat digunakan sebagai dasar untuk pengembangan lebih lanjut dalam produksi vaksin COVID berbasis protein rekombinan. Vaccination is one of the main strategies in combating the pandemic. Currently, most vaccines being developed are based on recombinant technology. Recombinant protein production frequently utilizes E. coli due to its ease of genetic manipulation and relative safety for development. Recombinant DNA technology employs various types of plasmids as primary vectors to facilitate the insertion of recombinant DNA into bacterial cells. The pET-32 plasmid is one such vector, designed for cloning and expressing recombinant proteins in E. coli. Although plasmid transformation methods in bacteria have been developed for a long time, the process often encounters several challenges. This study aims to develop an effective method for preparing competent cells and optimizing the transformation process. The competent cells were prepared using calcium chloride (CaCl₂) and dimethyl sulfoxide (DMSO), and the transformation of the pET-32-HCR-CTB gene into BL21 competent cells was optimized using a heat shock at 42°C for 45 seconds and 60 seconds. The results showed that the use of DMSO in competent cell preparation resulted in a transformation efficiency of 3.5 × 10³ CFU/µg. Bacterial clones that grew after the transformation process were tested using PCR, confirming the presence of the pET-32-HCR-CTB gene. Therefore, the variation in the BL21 competent cell preparation method and the optimized transformation conditions obtained in this study can serve as a foundation for further development of recombinant protein-based COVID vaccine production.
Evaluation of Drug Management Before and During the COVID-19 Pandemic In The Pharmaceutical Installation of NTB Provincial Hospital Wisnu, M. Ari; Khairani, Ayudia Cipta
Journal of Islamic Pharmacy Vol 10, No 1 (2025): J. Islamic Pharm.
Publisher : Universitas Islam Negeri Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jip.v10i1.32374

Abstract

The COVID-19 pandemic that occurred from 2019 to 2023 and has spread to nearly 190 countries in the world has caused a shortage of drug supply. The need for public medicines that must be available for health services makes hospitals must try to fulfill and currently, the COVID-19 pandemic situation is continuing so hospitals must be ready to provide health services to patients. This study aims to evaluate drug management in the Pharmacy Installation of the NTB Provincial Hospital before the COVID-19 pandemic in 2019 and during the COVID-19 pandemic in 2020. This study used a descriptive-evaluative method. The main data was collected through documents containing specific data on drug management history. Supporting data was collected through interviews with the pharmaceutical installation. The results of the suitability of drug management in the Pharmacy Installation of the NTB Provincial Hospital before the COVID-19 pandemic in 2019 obtained 5 indicators that did not meet the standards and 6 indicators that met the standards while during the COVID-19 pandemic in 2020 there were 7 indicators that did not meet the standards and 4 indicators that met the standards.
Molecular Docking of Hygrophila auriculata (Schum.) Heine Compounds Targeting PBP2 Protein in Neisseria gonorrhoeae Salmasfattah, Novyananda; Prayogi, Syaiful; Prasetyawan, Fendy
Journal of Islamic Pharmacy Vol 10, No 1 (2025): J. Islamic Pharm.
Publisher : Universitas Islam Negeri Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jip.v10i1.31740

Abstract

Antibiotic resistance in gonorrhoea cases and patients is detrimental. Amidst the rising cases of gonorrhoea caused by Neisseria gonorrhoeae, Hygrophila auriculata (Schum.) Heine has activity as an antibiotic for the disease. The penicillin-binding protein 2 (PBP2) is a transpeptidase that catalyses the formation of cross-bridges on bacterial cell wall peptidoglycan, which will be the target of this plant. The purpose of molecular docking study is to see the binding affinity, compounds in Hygrophila auriculata (Schum.) Heine and ceftriaxone which is used as a comparison drug, will be targeted at PBP protein. Discovery studio visualizer v21.1.0.20298 was used for PBP2 protein preparation and visualisation. DoG Site Scorer was used to predict ligand binding sites on PBP2 proteins. PyRx 0.8 was used for virtual screening, validating of the docking method, and ligand preparation. Compounds in Hygrophila auriculata (Schum.) Heine as ligands were derived from MPDB 2.0 and the following PubChem codes; apigenin CID 5280443, luteolin CID 5280445, allagic acid CID 5281855, gallic acid CID 370, quercetin CID 5280343, lupeol CID 259846, lupenone CID 92158, betulin CID 72326, stigmasterol CID 5280794, and comparator drug ceftriaxone CID 447043. The binding affinity of ellagic acid -9,8 from Hygrophila auriculata (Schum.) Heine was lower than ceftriaxone -9,4 on the target PBP2 protein. Some of the amino acid residues that appear in protein-ligand docking include: ALA A:310, THR A:500 and 347, LYS A:313, and SER A:362. These amino acid residues owned by the PBP2 protein serve as the bonding bridge. Ellagic acid, the compound has potential as an antibiotic in gonorrhoea. Further testing and studies are needed to strengthen the evidence of the findings in this study
Antidiabetes Activity of Ethanol Extract of Pandan Leaves (Pandanus amaryllifolius Roxb) in Male White Mice (Mus musculus) Jehan, Nabilah Nauli; Hidayah, Harismayanti; Khairani, Ayudia Cipta
Journal of Islamic Pharmacy Vol 10, No 1 (2025): J. Islamic Pharm.
Publisher : Universitas Islam Negeri Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jip.v10i1.32378

Abstract

Diabetes Mellitus is a metabolic disease characterized by hyperglycemia due to abnormalities in insulin secretion. This study aims to evaluate the antidiabetic effect of ethanol extract of fragrant pandan leaves (Pandanus ammarillyfolius Roxb) on aloxane-induced male white mice (Mus musculus). After alloxane induction, all test animals reached hyperglycemic conditions with blood glucose levels of ≥126 mgdL. The method used was the Paired Sample T-Test to analyze the difference in blood glucose levels before and after the treatment. The normality of the data was tested by the Shapiro-Wilk test, while the homogeneity was tested by the Leven test. The results showed that the most effective ethanol extract of fragrant pandan leaves reduced blood glucose levels at a dose of 600mgkgBB by 26%, a dose of 400mgkgBB by 21%, a dose of 200mgkgBB by 18%, a positive control using glibenclamide 0.65mgkgBB as much as 10% and a negative control using CMC-Na by 3%.
Analisis Kadar Etanol dalam Minuman Legen Menggunakan GC-FID dan Tinjauan Fatwa MUI tentang Produk Fermentasi Suhardi, Haidar Rafli Putra; Zummah, Atiqoh; Zahro, Dea Ma'rifatul; Rahmah, Firda Maghfiratur; Ainida, Anya Hayyu; Rani, Titis Eka
Journal of Islamic Pharmacy Vol 10, No 1 (2025): J. Islamic Pharm.
Publisher : Universitas Islam Negeri Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jip.v10i1.32098

Abstract

Legen merupakan minuman tradisional hasil sadapan nira pohon siwalan yang berpotensi mengalami fermentasi alami sehingga menghasilkan etanol. Penelitian ini bertujuan untuk menganalisis kadar etanol dalam sampel legen yang diperoleh dari kawasan Surabaya menggunakan metode Gas Chromatography-Flame Ionization Detector (GC-FID), serta mengevaluasi kesesuaiannya dengan ketentuan halal berdasarkan fatwa Majelis Ulama Indonesia (MUI) Nomor 10 Tahun 2018. Sebanyak tujuh sampel legen dikumpulkan secara acak dari pedagang kaki lima dan dianalisis kandungan etanolnya, disertai pengamatan karakteristik organoleptik (warna, aroma, dan viskositas) untuk mendeteksi indikasi fermentasi. Hasil menunjukkan kadar etanol bervariasi antara 0,15% (3B) hingga 11,31% (4B). Sampel dengan kandungan alkohol tertinggi memiliki aroma asam yang kuat yang mengindikasikan proses fermentasi terus berlanjut serta ketersediaan gula sebagai substrat fermentasi. Tiga sampel (1B, 2A, dan 4B) melebihi ambang batas etanol halal ( 0,5%) sebagaimana ditetapkan MUI, sehingga dinyatakan tidak memenuhi kriteria halal. Penelitian ini menegaskan pentingnya pengawasan mutu pada produk minuman fermentasi tradisional untuk memastikan keamanan konsumsi dan kesesuaiannya dengan syariat Islam.Legen is a traditional beverage obtained from the sap of the lontar palm, which has the potential for natural fermentation, thereby producing ethanol. This research aims to analyze the ethanol content in legen samples obtained from the Surabaya area using the GC-FID method, and to evaluate its compliance with halal provisions based on the MUI fatwa Number 10 of 2018. Seven legen samples were randomly collected from street vendors, and their ethanol content was analyzed, accompanied by observations of organoleptic characteristics (color, aroma, and viscosity) to detect indications of fermentation. The results showed ethanol content varied from 0.15% (3B) to 11.31% (4B). Samples with the highest alcohol content had a strong sour aroma characteristic, indicating that the fermentation process continued as well as the availability of sugar as a fermentation substrate. Three samples (1B, 2A, and 4B) exceeded the halal ethanol threshold ( 0.5%) as stipulated by MUI, thus being declared non-halal. This research emphasizes the importance of quality control in traditional fermented beverage products to ensure their safety for consumption and compliance with Islamic law.
Molecular Docking: Analysis of Mahogany Plant Compounds (Swietenia macrophylla King) against the ACE2 Enzyme of SARS-CoV-2 Amrulloh, Lalu Sanik Wahyu Fadil; Khairani, Ayudia Cipta
Journal of Islamic Pharmacy Vol 10, No 1 (2025): J. Islamic Pharm.
Publisher : Universitas Islam Negeri Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jip.v10i1.32426

Abstract

Various treatment approaches have been attempted to tackle severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)  infection. One approach to develop new drugs is through the utilization of medicinal plants. Mahogany (Swietenia macrophylla King) is one of the plants that is thought to have potential as an inhibitor of SARS-CoV-2. This study aims to determine the anti-SARS-CoV-2 potential of compounds in mahogany plants that have good interactions and interaction patterns with angiotensin-converting enzime 2 (ACE2) receptors. A total of ten mahogany plant compounds were tested for drug-likeness based on Lipinski screening which will then be docked to the ACE2 molecular target, using the molecular docking method. The parameters observed were binding energy values and amino acid residues. The results of molecular docking showed that the compounds predicted to have the highest binding affinity and have similar interaction patterns with natural ligands to the ACE2 molecular target were secomahoganin and stigmasterol. The secomahoganin and stigmasterol compounds are predicted to have good interactions with the ACE2 receptor.
Pengaruh Kombinasi Kitosan dan Karbopol 940 Terhadap Karakteristik Fisik dan Stabilitas Sediaan Gel Ekstrak Daun Kelor (Moringa oleifera L) Zatalini, Dioni Fadia; Bhagawan, Weka Sidha; Norachuriya, Zedny
Journal of Islamic Pharmacy Vol 10, No 1 (2025): J. Islamic Pharm.
Publisher : Universitas Islam Negeri Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jip.v10i1.32255

Abstract

Gel merupakan salah satu sediaan topikal yang memiliki keuntungan seperti bewarna jernih, memberikan sensasi dingin, tidak berminyak, mudah menyebar di kulit sehingga dapat maksimal memberikan efek teraupetik. Gelling agent merupakan komponen penting dalam pembentukan gel. Kitosan merupakan polimer alam yang dapat membentuk gel pada larutan asam. Sedangkan karbopol 940 dapat menghasilkan gel bewarna jernih dan stabilitasnya baik selama penyimpanan. Tujuan dari penelitian ini adalah untuk mengetahui pengaruh kombinasi karbopol 940 dan kitosan pada sediaan gel ekstrak daun kelor terhadap karakteristik fisik dan uji stabilitas selama 4 minggu. Pembuatan gel ekstrak daun kelor menggunakan ekstrak etanol daun kelor sebesar 5%. Kombinasi gelling agent yaitu karbopol 940 1% dan kitosan 0,5%, 1%, 1,5%. Uji karakteritik dan stabilitas meliputi organoleptis, homogenitas, pH, viskositas, daya sebar dan stabilitas selama 4 minggu. Hasil menunjukkan gel ekstrak daun kelor bewarna coklat tua, kental, bau khas daun kelor serta homogen dan tidak mengalami perubahan signifikan selama disimpan 28 hari. Nilai Uji pH sediaan gel ekstrak daun kelor tidak mengalami perubahan setelah disimpan selama 4 minggu (4,94-5,20) menjadi 5,09-5,65). Stabilitas viskositas sediaan gel ekstrak daun kelor mengalami penurunan dari minggu ke-1 2,964 cps-4420 cps menjadi 2,438 cps-3556 cps setelah minggu. Pada uji daya sebar terjadi peningkatan setelah disimpan selama 4 minggu (4,2 cm- 5,9 cm menjadi (5,1 cm – 6,9 cm). Berdasarkan hasil tersebut semua formula gel kitosan-karbopol 940-ekstrak daun kelor telah memenuhi persyaratan.

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