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All Journal African Multidisciplinary Journal of Sciences and Artificial Intelligence Open Access DRIVERset African Journal of Sciences and Traditional Medicine Open Access DRIVERset
Chinedu, Emmanuel Kinsley
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Nursing Public Health

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Organocatalysis: A Revolutionary Approach in Organic Synthesis Ahmad, Kabiru Bashir; Chinedu, Emmanuel Kinsley; Pambani, Reuben; Adam, Ansar Bilyaminu; Abubakar, Musa Yahaya; Shamsuddeen, Ruslan
African Multidisciplinary Journal of Sciences and Artificial Intelligence Vol 1 No 1 (2024): African Multidisciplinary Journal of Sciences and Artificial Intelligence
Publisher : Darul Yasin Al Sys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/amjsai.v1i1.3518

Abstract

Organocatalysis has emerged as a powerful tool in organic synthesis, enabling the efficient and selective formation of complex molecules. This review highlights the recent advances in organocatalysis, including the development of new catalysts, reactions, and applications. The advantages and limitations of organocatalysis are discussed, and its potential for scalability and sustainability is evaluated. The review also explores the mechanistic insights and future directions in this field, demonstrating the versatility and impact of organocatalysis in modern organic synthesis. This paradigm shift not only addresses the pressing environmental challenges but also paves the way for more innovative and economically viable synthetic strategies. As a result, organic synthesis is poised to play a crucial role in advancing pharmaceuticals, materials science, and agrochemicals, driving forward a more sustainable and resilient chemical industry.
Natural Products as Leads for Neglected Trophical Diseases (NTDs) Treatment; A Chemical and Biological - Review Mathew, Twan Sale; Chinedu, Emmanuel Kinsley; Haladu, Muhammed; Abubakar, Musa Yahaya; Adam, Ansar Bilayamin; Shamsuddeen, Ruslan
African Multidisciplinary Journal of Sciences and Artificial Intelligence Vol 1 No 1 (2024): African Multidisciplinary Journal of Sciences and Artificial Intelligence
Publisher : Darul Yasin Al Sys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/amjsai.v1i1.3735

Abstract

Natural compounds are mostly found in medicinal plants that are used to treat various ailments. They are distinguished by their structural complexity and diversity, which span a wide chemical universe and present both benefits and shortcomings to the process of discovering novel drugs. Neglected tropical diseases (NTDs) are common tropical diseases that impact over one billion people globally. Numerous pathogens, such as bacteria, fungi, viruses, parasites, and poisons, are responsible for them. Natural products have always been important in the search for new drugs to treat differents diseases including NTDs. The purpose of this chapter is to provide an update on the evaluation of both the chemical and biological properties of natural compounds that have been extracted and identified from plant sources, and may be utilized as viable candidates for the development of new drugs treat NTDs with lower incidence such as: Buruli ulcer, dracunculiasis, echinococcosis, food-borne trematodiases, leprosy, lymphatic filariasis, parasitics, schistosomiasis, soil-transmitted helminthiases, taeniasis/cysticercosis, trachoma and yaws. This chapter also intends to make a critical review on the chemical analysis of natural products’ structure and classification, biological evaluation of natural products’ antiparasitic, anti-inflammatory and immunomodulatory activities. In conclusion, Natural products continue to be a key source of fresh ideas for treating NTDs. Their distinct methods of action and variety of chemicals offer potential for the development of new treatments.
Co-Authors Abdullahi, Saeed Abubakar, Musa Yahaya Adam, Ansar Bilayamin Adam, Ansar Bilyaminu Ahmad, Kabiru Bashir Bilyamin, Ansar Haladu, Muhammed Mathew, Twan Sale Pambani, Reuben Shamsuddeen, Ruslan