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Hartono Kahar
Fakultas Kedokteran Universitas Muhammadiyah Surabaya

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Journal : proceeding umsurabaya

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Kelainan Hemostasis pada pasien Covid-19 Hartono Kahar; Nabil Salim
PROCEEDING UMSURABAYA 2020: Prosiding Seminar Online UPDATES ON COVID-19 : MULTIDICIPLINARY PERSPECTIVE
Publisher : Universitas Muhammadiyah Surabaya

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Abstract

AbstractCoagulopathy in SARS-CoV-2 (Covid-19) patients is an emerge situation to treat because itincreases morbidity and mortality. Increased levels of tPA indicate spontaneous fibrinolysis aswell as a significant increase in Fibrin / Fibrinogen degradation product (FDP) and D-dimerin Covid-19 patients. The invasion of the Covid-19 virus into the endothelial blood vesselscauses endothelial cell dysfunction, a decrease in the fibrinolytic function of the cells, whichpredisposes to thrombus formation. In severe cases, IL-6 which is also released due toendothelial damage predisposes to Sepsis-Induced Coagulopathy (SIC) and DisseminatedIntravascular Coagulation (DIC).Keywords: SARS-CoV-2 (Covid-19), Coagulopathy, SIC, DIC.
Co-Authors Nabil Salim