This study aims to examine the effect of asset growth, firm size, leverage, and liquidity on profitability in manufacturing companies listed on the Indonesia stock exchange for the period 2015-2017.The population in this study are all Manufacturing Companies Registered on the Stock Exchange of the 2015-2017 Period. The sample selection uses a purposive sampling method. The analytical tool used in this study is multiple linear regression analysis.The test results show that asset growth, company size, and liquidity have a significant positive effect on profitability. While leverage does not have a significant negative effect on profitability.