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All Journal Jurnal Surya Medika JURNAL ANALIS LABORATORIUM MEDIK Jaringan Laboratorium Medis Media Publikasi Promosi Kesehatan Indonesia (MPPKI) Jurnal Ilmiah Pengabdian Masyarakat Bidang Kesehatan Jurnal Laboratorium Khatulistiwa
Sofyanita, Eko Naning
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Biochemistry, Genetics & Molecular Biology Dentistry Education Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health

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PENGARUH DAYA HAMBAT PERASAN BAWANG PUTIH TUNGGAL (Allium Sativum L) TERHADAP PERTUMBUHAN BAKTERI Salmonella typhi Sofyanita, Eko Naning
Jurnal Laboratorium Khatulistiwa Vol 6, No 2 (2023): MEI 2023
Publisher : poltekkes kemenkes pontianak

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30602/jlk.v6i2.630

Abstract

Typhoid fever is a disease caused by Salmonella typhi bacterial infection. This disease is one of the global infections throughout where the level of typhoid resistance to chloramphenicol in Indonesia itself is increasing, and it has even been reported that resistance increases 16% to 81% in 1 year in one location. Single garlic contains an active compound, namely allicin, which is used as an antibacterial which can inhibit the growth of gram-positive and gram-negative bacteria. Therefore, single garlic is expected to be used as an alternative in overcoming the problem of resistance to bacteria Salmonella typhi that causes typoid. This study used the disc diffusion method on MHA agar media to test the inhibition of single garlic juice against Salmonella typhi bacteria. This type of experimental research with descriptive criteria, with 4 repetitions. Results by measuring the diameter of the power area of the test sample in the concentration group of 50%, 75% and 100%. The results of this study the average diameter of the inhibitory power at a concentration of 100% is 25 mm, at a concentration of 75% is 21 mm, and at a concentration of 50 % i.e. 17 mm. The results of statistical tests with simple linear regression showed that p (0.000) <α 0.05 means that Ha is accepted, so it can be stated that there is an effect of various concentrations of single garlic (Allium Sativum L) on the inhibition zone of Salmonella typhi bacteria.
Gambaran Ureum dan Kreatinin pada Pasien Penyakit Ginjal Kronik yang Menjalani Hemodialisis Afriansya, Roni Roni; Sofyanita, Eko Naning; Suwarsi, Suwarsi
Jaringan Laboratorium Medis Vol. 2 No. 1 (2020): May 2020
Publisher : Poltekkes Kemenkes Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31983/jlm.v2i1.5813

Abstract

Chronic Kidney Disease is evident if the blood urea level is more than 200 mg/dl. Uremia causes a malfunction in almost all organ systems such as; fluid and electrolyte disorders, metabolic endocrine, neuromuscular, cardiovascular and pulmonary, skin, gastrointestinal, hematological, and immunological. Hemodialysis is an attempt to reduce the symptoms of uremia so that the patient's clinical condition can also improve. The purpose of this study was to determine the description of Ureum and Creatinine in CKD Patients undergoing Hemodialysis. This type of research is observational descriptive. The sample included all CKD patients undergoing hemodialysis at the Ir Sukarno Sukoharjo Regional Hospital in 2019 who met the inclusion criteria, so as many as 83 samples were obtained. The type of data is secondary data obtained from medical records. The results showed that most patients were in the 40-60 years age group of 72% and the majority of the male sex were 51 patients (61%). Urea and creatinine appearance in patients undergoing hemodialysis has increased very high. In 83 patients with CKD increased serum creatinine levels (> 100%) with a mean creatinine level in men of 11.80 mg / dL and women of 9.73 mg / dL and an increase in ureum levels with a mean of 167 men, 09 mg / dL and women of 164.39 mg / dL. This study concludes that all patients with CKD have increased levels of urea and creatinine by more than 100%.
Hubungan Kadar Hemoglobin dan Kadar Kreatinin Darah pada Pasien Gagal Ginjal Kronik Pasca Transfusi Berulang Sofyanita, Eko Naning; Afriansya, Roni; Palupi, Nur Indah
Jaringan Laboratorium Medis Vol. 2 No. 2 (2020): November 2020
Publisher : Poltekkes Kemenkes Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31983/jlm.v2i2.7030

Abstract

Kidneys are part of the body that has an important role. One of the functions of the kidney is the production of erythropoietin. Erythropoietin stimulates the production of red blood cells. People or patients who have kidney problems can cause anemia. This study aims to determine the relationship between hemoglobin levels and blood creatinine levels in patients with chronic kidney disease after receiving a transfusion. Blood creatinine levels in this study were used as an index to measure kidney function. The study was conducted at the Wira Tamtama Hospital Semarang by taking data on 20 patients in 2020 with chronic kidney disease and taking data on hemoglobin (cut-off 12 g/dL) and serum creatinine (cut-off 1.5 mg/dL). The relationship between the two was calculated by chi-square test and found 80% of patients with low hemoglobin in patients with high creatinine levels and 0% of patients with low hemoglobin in patients with normal creatinine levels (p=0.040). There is a risk of decreased hemoglobin levels (OR = 3,442) in patients with high creatinine levels. It was concluded that there was a significant relationship between hemoglobin levels and blood creatinine levels and patients with high creatinine levels tended to be at risk of anemia.
Rasio Penutupan Luka pada Tikus Diabetes Diinduksi Streptozotocin dengan Perlakuan Dressing Tipe Pasif dan Interaktif (Penelitian Pendahuluan) Sofyanita, Eko Naning; Iswara, Arya
Jaringan Laboratorium Medis Vol. 3 No. 2 (2021): November 2021
Publisher : Poltekkes Kemenkes Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31983/jlm.v3i2.8045

Abstract

Deparaffinization is a stage before the staining process to remove/dissolve paraffin so that the absorption of color in tissue preparations is maximized. Deparaffinization is usually carried out using xylol and toluol. Xylol has toxic effects including acute neurotoxicity, heart and kidney damage, hepatotoxicity, fatal blood dyscrasias, skin erythema, dry skin, peeling skin, and also has a carcinogenic effect. The toxicity effect of olive oil is lower than that of xylol. Oils that have non-polar properties can remove the remaining paraffin contained in the tissue. The purpose of this study was to determine the microscopic appearance of the kidney tissue preparations of mice deparaffinized with olive oil on hematoxylin eosin (HE) staining. The type of research used is experimental research which is analyzed with a descriptive approach. The results of the assessment of preparations deparaffinized with xylol in 80 visual fields obtained 100% good preparations and preparations deparaffinized with olive oil in 80 visual fields obtained 0% poor preparations, 11.3% poor preparations, and 88.7% good preparation. So it can be said that better results are found in the microscopic picture of the kidney preparations of mice (Mus musculus) deparaffinized with xylol.
Tingkat Pengetahuan terhadap Donor Darah pada Masyarakat Pendonor Afrianti, Dina; Susilawati, Elis; Sofyanita, Eko Naning
Jaringan Laboratorium Medis Vol. 4 No. 1 (2022): May 2022
Publisher : Poltekkes Kemenkes Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31983/jlm.v4i1.8445

Abstract

Blood donation is an activity to donate blood for transfusion purposes. The number of voluntary blood donors in Indonesia is around 20% of the total production of blood bags per year, the rest is met from replacement donors. People are generally reluctant to donate blood because of fear of pain when blood is drawn using a syringe, fear of running out of blood, resulting in anemia, contracting the disease through blood donors, feeling unwell to donate blood and feeling that it is enough to only donate blood once. This is a factor that causes the limited number of donors due to limited knowledge. Research Objectives: To see an overview of the level of knowledge about blood donors in the community of donors at Pekalongan City. Methods: The type of research used is descriptive quantitative with a cross sectional approach with a questionnaire to determine the level of knowledge of the donor community. Results: Most of the blood donors at the Pekalongan City are Male 73 respondents (73%), the highest percentage aged 17-30 years as many as 54 respondents (54%), high school education, namely as many as 49 respondents (49%). Most of the donor knowledge level is said to be good, namely 88 respondents (88%). Conclusion: Most of the donor community at the Pekalongan City have a good level of knowledge about blood donation.
Minyak Zaitun Sebagai Pengganti Xylene pada Prosesing Jaringan Histologis untuk Pewarnaan Kulit dan Hepar Mencit dengan Hematoxylin Eosin: Sebuah Studi Perbandingan Sofyanita, Eko Naning; Iswara, Arya; Priyatno, Djoko
Jaringan Laboratorium Medis Vol. 4 No. 2 (2022): November 2022
Publisher : Poltekkes Kemenkes Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31983/jlm.v4i2.8688

Abstract

Clearing results in histological processing can be affected due to tissue density and viscosity of the clearing agent. Xylene is the most commonly used aromatic solvent for clearing agents and deparaffinizing agents in histopathology laboratories, but xylene is one of the most dangerous chemicals found in histology laboratories. Based on the dangers posed by xylene, a replacement material is needed. Several xylene substitutes such as reagents derived from limonene, aliphatic hydrocarbons, vegetable oils and mineral oils have been commercially developed, but the available xylene substitutes are still less effective, more expensive, and still as dangerous as xylene itself. Substitutes that are considered safer are from natural oils, one of which is olive oil which has similarities with xylene, namely in hydrocarbon and phenol compounds. This study used two types of tissue, namely skin and liver from mice (Mus musculus) which were cut into two parts; the first part uses xylene as and the other part uses olive oil as a clearing agent. The assessment of hematoxylin eosin staining results were determined based on the category of assessment of cell structure, such as the cell nucleus, cytoplasm, and color uniformity carried out by three readers and five fields of view for each microscopic slide at 40X magnification of the objective lens. Comparison of observations of the xylene group in skin and liver tissue 100% got a good score on the cell nucleus, cytoplasm, and color uniformity. (p=1,000). The olive oil group had a slight difference in color uniformity in liver tissue when compared to skin, but not statistically different (p=0.773). The comparison of the overall readings of the xylene and olive oil groups on skin and liver tissue also showed no statistically different (p=0.262). So it can be concluded that olive oil can be recommended as a substitute for xylene in the clearing process in histological tissue processing.
Deteksi Karsinoma Nasofaring Mengunakan Rapid Test Uji Imunokromatografi pada Petugas SPBU Afriansya, Roni; Rosidah, Umi; Sofyanita, Eko Naning
Jaringan Laboratorium Medis Vol. 5 No. 1 (2023): May 2023
Publisher : Poltekkes Kemenkes Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31983/jlm.v5i1.9337

Abstract

Nasopharyngeal cancer (NPC) is the 4th most common malignancy in Indonesia, after breast, cervical and lung cancer. The risk factors for this cancer are Epstein-Barr virus, gender, race, adult age 30-50 years, family history, drinking alcohol and smoking. The prevalence of NPC in Indonesia is 6.2/100,000, with nearly 13,000 new cases, but this is a small proportion that has been documented. Adham et al (2012) reported that NPC is the most common head and neck cancer (28.4%), with a male-female ratio of 2:4 and is endemic to the island of Java. The existence of knowledge about NPC starting from prevention, early detection, appropriate treatment will be able to help overcome problems caused by nasopharyngeal cancer. Early detection is very important. If NPC is found at an early stage, the cure rate is quite high, reaching 90%. The purpose of this study was to find out whether there were gas station workers in Semarang City who experienced NPC. This study used an analytic survey method with a cross-sectional approach. The results of the study of 20 Semarang City Gas Station officers found that the characteristics based on age were the most in the range 31-50, namely 70%. Characteristics based on gender of the 20 gas station attendants are all male (100%). Characteristics based on length of service are 1 - 10 years (35%), 11 - 20 years (35%) and 21 - 30 years (30%) respectively. Characteristics based on smoking history, 55% of respondents smoked and 45% did not smoke. And the NPC examination results of all respondents (100%) were NPC negative.
Gambaran Nilai Index Trombosit pada Pasien Tuberulosis Paru yang Mengonsumsi Obat Anti Tuberkulosis Widiyanto, S.Y. Didik; Qomariyah, Nurul; Sofyanita, Eko Naning
Jaringan Laboratorium Medis Vol. 5 No. 2 (2023): November 2023
Publisher : Poltekkes Kemenkes Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31983/jlm.v5i2.9646

Abstract

Tuberculosis (TB) is a disease caused by the bacterium Mycobacterium tuberculosis which mostly attacks the lungs. Based on several studies, it is stated that tuberculosis sufferers who take OAT for healing experience side effects in the form of lowering the platelet index due to reactions from drugs that lyse platelets. This research is a descriptive study with a cross sectional design. Research was conducted on 30 respondents who consumed OAT. The results of this study obtained results of more than 50% on one of the platelet indices, namely the PWD value, which was obtained with low results with a total of 19 patients (63.3%), while for other indices such as platelet counts there were 21 patients (70%) , MPV in 28 patients (93%) and PCT in 23 patients (77%) had normal results. The conclusion of this study is that platelet index examinations in TB patients tend to be low in MPV and PDW, while they show high results in PLT and PCT examinations.
Mentoring and Empowerment Diploma Three Student in Blood Bank Technology, Health Polytechnic, Ministry of Health, Semarang, Through Training in Making Soy Milk as an Effort to Prevent Anemia Afrianti, Dina; Hartono, Rodhi; Setyowatiningsih, Lilik; Sofyanita, Eko Naning; Wahyudi
Jurnal Ilmiah Pengabdian Masyarakat Bidang Kesehatan (Abdigermas) Vol. 2 No. 1 (2024): Jurnal Ilmiah Pengabdian Kepada Masyarakat Bidang Kesehatan (Abdigermas)
Publisher : CV Media Inti Teknologi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58723/abdigermas.v2i1.169

Abstract

Mentoring participants know about anemia and its symptoms. Participants know the equipment and materials needed to make soy milk and know the steps on how to make soy milk and participants are able to give a demonstration of making soy milk to the residents of the target village. Residents of the assisted villages know how to make soy milk. Community service activities with the Entrepreneurship Development Program (PPK) scheme with the theme "Assistance in the Empowerment of Diploma Three Technology Students at the PolkesMar Blood Bank through training in making soy milk (Soymilk) as an effort to prevent anemia" was carried out on Friday 28 July 2023 with a target of 10 people participating. consisting of 8 active students and 2 alumni. The output is in the form of videos and pamphlets on making soy milk that have received IPR certificates as well as the expertise of training participants resulting from a series of training activities on making soy milk (Soymilk) targeting students and alumni. This has also been implemented in community service activities for the target village residents in Pundan Hamlet, Subdistrict. Kebondowo Banyubiru, Semarang district, which will be held on Sunday 15 October 2023. The successful achievement of this activity was that all participants in the training on making soy milk were able to give demonstrations on making soy milk to the residents of the target villages. Residents of the assisted villages were given education about anemia and solutions to preventing anemia, the committee also showed videos of making soy milk, distributed pamphlets and gifts to residents of the assisted villages.
PENGARUH PENGGUNAAN MINYAK KELAPA MURNI SEBAGAI LARUTAN CLEARING PADA SEDIAAN HEPAR MENCIT Sofyanita, Eko Naning; Azahra, Nabila
Jurnal Analis Laboratorium Medik Vol 8 No 1 (2023): JURNAL ANALIS LABORATORIUM MEDIK
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51544/jalm.v8i1.3945

Abstract

Salah satu tahapan dalam pemrosesan jaringan dengan histoteknik adalah clearing yang menggunakan larutan xylol. Xylol sering digunakan sebagai agen clearing karena prosesnya cepat dan harganya tidak terlalu mahal, tetapi penggunaan xylol sudah mulai ditinggalkan karena sifatnya yang karsinogenik. Minyak mempunyai karakter bersifat non polar sehingga dengan sifat non polar dari minyak kelapa ini dapat menghilangkan sisa parafin yang terdapat pada jaringan dan dapat digunakan sebagai alternatif larutan clearing. Tujuan penelitian ini adalah untuk mengetahui pengaruh penggunaan minyak kelapa murni (virgin coconut oil) sebagai alternatif larutan clearing terhadap gambaran makroskopis jaringan hepar mencit (Mus musculus). Metode penelitian ini menggunakan penelitian eksperimental dengan pendekatan one-shot case study. Hasil penelitian ini dilihat dari parameter transparansi dan tekstur menghasilkan 16 (100%), preparat baik sedangkan parameter kemudahan pemotongan didapat 10 sediaan baik (62,5%). Uji Mann-Whitney didapatkan nilai p-value < 0,05 maka ada perbedaan kualitas sediaan jaringan hepar mencit (Mus musculus) yang dijernihkan menggunakan xylol dan minyak kelapa murni (virgin coconut oil). Kesimpulan pada penelitian ini yaitu minyak kelapa murni (virgin coconut oil) dapat digunakan sebagai alternatif larutan clearing berdasarkan gambaran makroskopis jaringan hepar mencit (Mus musculus) dengan hasil kualitas sediaan jaringan yang baik tetapi kualitasnya masih tidak semaksimal penggunaan larutan xylol.
Co-Authors Achmad Zulfa Juniarto Ari Suwondo Arya Iswara Azahra, Nabila Dina Afrianti1 Djoko Priyatno, Djoko Heri Nugroho Nurul Qomariyah Palupi, Nur Indah Raden Mohamad Herdian Bhakti Rodhi Hartono Roni Afriansya Rosidah, Umi Setyowatiningsih, Lilik Siwi, Utami Purnama Susilawati, Elis WAHYUDI Widiyanto, S.Y. Didik