Background: Medical waste is unwanted bioÂloÂgical products that are highly infectious in naÂture. It is broadly classified as infectious waste and bioÂhazardous waste, and can easily spread any disease virally and can even pose a danger to life. MeÂdical waste is found in hospitals, laboÂratories, reÂsearch centres, tattoo parlours, and others. It has to be disposed properly otherwise it poses a health and environmental danger. This study aimed to examine the effects of motivation and supervision on adherence to medical waste policy in South Labuhanbatu, North Sumatera.Subjects and Method: This was a cross-secÂtiÂonal study carried out in South Labuhanbatu, NorÂth Sumatera. A sample of 34 health care worÂkers were selected for this study, consisting of health center doctors, private doctors, and health clinic owner. The dependent variable was adheÂrenÂce to medical waste policy. The independent variÂables were motivation and supervision. The data were collected by questionnaire and analyzÂed by multiple logistic regression.Results: Adherence to medical waste policy was affectÂed by strong motivation (OR= 6.31; 95%CI= 2.74 to 9.33; p= 0.048) and regular supervision (OR= 5.56; 95%CI= 3.42 to 8.09; p= 0.039).Conclusion: Adherence to medical waste policy is affected by motivation and supervision.Keywords: waste policy, adherence, motivation, supervision.Correspondence: Syahrul An. Masters Program in Public Health, Universitas Sumatera Utara, Medan, North Sumatera. Email: 44nregar@gmail.com. Mobile: 082366502449.Journal of Health Policy and Management (2020), 05(02): 146-151ttps://doi.org/10.26911/thejhpm.2020.05.02.07