The entire World is going through hard times because of the emergence of new pandemic named Coronavirusor COVID-19. The virus originated from Wuhan and is spreading Worldwide. There are many questionsarising regarding the origin of this fatal virus; whether it is natural or man-made. In the past years, manymicroorganisms were used as a bio-warfare agents for causing destruction. In 2001, anthrax attack tookplace in US by the use of bacteria, Bacillus anthracis which acted as a bioweapon and lead to number ofdeaths in Texas, US. This review summarises the origin, epidemiology, medico-legal aspectsand the recentresearches of the virus indicating its nature of being manmade or a natural virus