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All Journal Indian Journal of Forensic Medicine & Toxicology
Sreepreeti Champatyray1 , Priyanka Debta2 , Neeta Mohanty3 , Saurjya Ranjan Das4
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Journal : Indian Journal of Forensic Medicine

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Tumor Associated Macrophages: A Review with Institutional Study Sreepreeti Champatyray1 , Priyanka Debta2 , Neeta Mohanty3 , Saurjya Ranjan Das4
Indian Journal of Forensic Medicine & Toxicology Vol. 14 No. 4 (2020): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v14i4.13096

Abstract

Aims: To study the expression of tumor-associated macrophages in different grades of squamous cellcarcinoma and find the association between their expression and local recurrence, metastasis.Methodology: Thirty tumor biopsy samples of oral squamous cell carcinoma in T1N0M0 and T2N0M0stages. Ten biopsy specimen of normal oral mucosa that are taken during minor oral surgical procedure withpatient consent.Result: Macrophages were found to have better specificity for local recurrence, metastasis, and survival.Further, higher expression of biomarkers was associated with shorter survival. We have analyzed thedifferential expression of MMP 9 in different grades of OSCC & compare their expression with differentTNM staging of tumors.Conclusions: Concluding this review of tumor-associated macrophages in comparison with OSCC cases.Since metastases are the principal cause of death in cancer patients, a greater understanding of the process oftumor invasion and metastasis is essential in leading to the identification of new therapeutic targets.
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