The development of bioactive surgical additives to regulate the inflammation and increase the speed ofthe healing process is one of the great challenges in clinical research. In this sense, platelet-rich fibrin(PRF) appears as a natural and satisfactory alternative with favorable results and low risks. The followingreview attempts to summarize the relevant literature regarding the technique of using PRF, focusing on itspreparation, advantages, and disadvantages of using it in clinical applications and its updates. PRF alone orin combination with other biomaterials seems to have several advantages and indications both for medicineand dentistry, due it is a minimally invasive technique with low risks and satisfactory clinical results