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Uddin, Mohammad Nasir
Professor of Chemistry, University of Chittagong, Bangladesh
Medicine & Pharmacology

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Journal : INDONESIAN JOURNAL OF PHARMACY

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Formulation of Ketorolac Tromethamine for Controlled Release in Gastrointestinal and Colonic Delivery System Hossain, Md. Amzad; Shill, Swapon Kumar; Khan, Shakhawat Hasan; Hossen, S. M. Moazzem; Uddin, Mohammad Nasir
Indonesian Journal of Pharmacy Vol 29 No 2, 2018
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1370.121 KB) | DOI: 10.14499/indonesianjpharm29iss2pp49

Abstract

A suitable matrix system of ketorolac tromethamine (KTR) formulation has been developed with the aim of increasing the contact time, achieving controlled release, reducing the frequency of administration, improving patient compliance. In this concern an enteric-coated KTR matrix tablet intended for specific delivery of drugs to the colon by combining the use of a time dependent core with a pH-sensitive film coating. Eudragit L100, with a threshold pH 7, was selected as coating material.  New formulation is proved to be noble as to KTR delivery through both gastrointestinal and colonic system. New formulation is considered to reduce gastrointestinal side effects and achieve high local drug concentration at the afflicted site in the gastro-intestine and colon. 
Co-Authors Hossain, Md. Amzad Hossen, S. M. Moazzem Khan, Shakhawat Hasan Shill, Swapon Kumar