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Manal, Gadmour
Faculty of pharmacy, Univ. of Tripoli, Tripoli, Libya, 13645 Tripoli- Libya
Medicine & Pharmacology

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Journal : INDONESIAN JOURNAL OF PHARMACY

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CYTOTOXIC ACTIVITY OF SELECTED LIBYAN MEDICINAL PLANTS ON HUMAN BREAST ADENOCARCINOMA CELL LINE (MCF-7) Jamal, Elmezogi; Gazala, Ben Hussien; Mabrouk, Erhuma; Manal, Gadmour; Abdulmotaleb, Zetrini; Abossa, Abdolgader; Shilpi, Jamil Ahmad
Indonesian Journal of Pharmacy Vol 24 No 2, 2013
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (465.789 KB) | DOI: 10.14499/indonesianjpharm24iss2pp127-130

Abstract

Three Libyan plants namely Ballota pseudodictamnus, Hedera helix, Thapsia garganica were tested for anticancer activity. The plants, collected from Aljabal-Al-Akhdar area of Libya in April 2010 were shed dried and subjected to Soxhlet extraction by methanol. Phytochemical screening indicated the presence of 2-deoxy sugars, flavonoids, saponins and tannins but absence of alkaloids in all three plants under investigation. Antiproliferative activity was performed breast adenocarcinoma cell line (MCF7). At the concentration of 100µg/mL, B. pseudodictamnus, T. garganica and H. helix showed 90, 60 and 5% cell death, respectively as compared to the control. Key words: Antiproliferative; Breast adenocarcinoma; Cell l ine MCF-7
Co-Authors Abdulmotaleb, Zetrini Abossa, Abdolgader Gazala, Ben Hussien Jamal, Elmezogi Mabrouk, Erhuma Shilpi, Jamil Ahmad