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Muthmainah . .
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Biochemistry, Genetics & Molecular Biology Education Health Professions Medicine & Pharmacology

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Efek Proteksi Ekstrak Buah Naga Putih (Hylocereus undatus) terhadap Jumlah Sel Spermatid Mencit (Mus musculus) yang Dipapar Asap Rokok Oktavia, Wida Pratiwi; ., Muthmainah .; Sari, Yulia .
Nexus Biomedika Vol 2, No 3 (2013): Nexus Biomedika
Publisher : Nexus Biomedika

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Background: White dragon fruit (Hylocereus undatus) contains vitamin C, E, A and polyphenol as antioxidant. This study aimed to prove the effects of white dragon fruit to to increase number of mice spermatids that exposured by cigarette smoke and to know what the effect of  the increasing dose of the extract to the number of mice spermatid. Methods: This study was an experimental laboratory research with the posttest only control group design. The subject of this research  were 28 male Swiss Webster mice (Mus musculus), aged 8–12 weeks and 20 grams weight. The subjects were arranged by incidental sampling into 4 groups that each group consisted of 7 mice. The negative control group (KKn) was adminstered aquadest while the positive control group (KKp) was exposured by cigarette smoke. The first treatment group (KP1) and the second treatment group (KP2) was successively administered 70 mg and 140 mg white dragon fruit extract per 20 g body weight. Two hours later, the subjects in KP1 and KP2 were exposured to cigarette smoke. This treatments were conducted for 14 days. On day 15th, subjects were sacrificed with neck dislocation and both testicles were stained with HE for microscopy study. The data were analyzed with Kruskall-Wallis test and Mann-whitney test (α=0.05) Results: Mean of spermatids mice in KKn, KKp, KP1 and KP2 were 358.29±16.222; 241.14±36.953;  375.79±74.785; and 436.14±33.629, in a row. Kruskall-Wallis test showed that the significance value was 0.000 (p <0.05). Mann-Whitney test showed significant differences between KKn-KKp, KKn-KP2, KKp-KP1, KKp-KP2, KP1-KP2 and no significant difference between the KKn - KP1. Conclusion: The white dragon fruit extract inhibited the number of damage spermatids of mice that exposured by cigarette smoke and the increasing doses of the extract enlarged the number of spermatids mice exposured by cigarette smoke Keywords: white dragon fruit extract, cigarettes, mice spermatid damage  
Estimated Brain Volume Could Affect the Learning Achievement on Medical Student of Sebelas Maret University Auliansyah Aldisela Januar Sukamto; Muthmainah . .; Suyatmi . .
Nexus Pendidikan Kedokteran dan Kesehatan Vol 5, No 1 (2016): Nexus Pendidikan Kedokteran & Kesehatan
Publisher : Fakultas Kedokteran Universitas Sebelas Maret Surakarta

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Introduction: Cranium capacity can reflect the volume of a person's brain. Brain volume is used to estimate a person's intelligence. Intelligence is a person's ability to learn and to understand something new. Intelligence is governed by the left cerebral cortex. Learning achievement is influenced by level of intelligence. The aim of this study was to prove that the correlation between estimated brain volume and learning achievement. Methods: This research was an observational analytic study with cross-sectional design conducted in Medical Faculty of Sebelas Maret University in October, 2015. Samples from this study were 4th year male students of medical faculty. Sixty nine samples were selected by simple random sampling method. Head height, width and length of the participants were measured to determine the brain volume while exams scores were used as learning achievement indicator. Data analysis was performed using Pearson correlation test. Results: The mean of Estimated brain volume and learning achievement measurement were 1614.35, 105.08 cc and 63.9, 4.48 respectively. The majority of samples (85.5%) had an estimated brain volume more than 1500 cc while 14.5% of samples had an estimated brain volume less than 1500 cc. Most of the samples (89.9%) had satisfactory learning achievement while only 10.1% had a good learning achievement. Data analysis using Pearson correlation test showed p = 0.000 and r= 0.555. Conclusion: There was a positive correlation between estimated brain volume and learning achievement on Medical student of Sebelas Maret. This means that the higher estimated volume of brain, the higher the learning achievement. Keywords: estimated brain volume, learning achievement, medical student
Roxburghine B and OxoxylopinePotential as Hepcidin Antagonist Insilico for Inflammatory Anemia Safirah . Yotriana; Yuliana Heri Suselo; Muthmainah . .
Nexus Biomedika Vol 6, No 2 (2017): Nexus Biomedika
Publisher : Nexus Biomedika

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Introduction: Anemia affects half a billion women in the world and become a problem, especially in pregnant women. One of the cause of anemia is inflammatory disease which also has a high prevalence in Indonesia. Therapies currently used to treat anemia are based on the underlying disease. Anticalin is a protein that works as hepcidin antagonist. Anticalin has completed the clinical phase II, but it has not been distributed to public market yet. Therefore, a new, easily accessible and more effective drug is required. Indonesian herbs have been widely used as medicinal plants in the community and are potential to be developed as drugs. The purpose of this study is to identify Indonesian phytochemicals that can act as hepcidin antagonist. Methods: The research was a bioinformatics study with molecular docking method. Three-dimensional structure of human hepcidin as a target protein and Anticalinas a standar therapy were downloaded from the website of the Protein Data Bank (PDB). The active compounds were obtained from HerbalDB and the three-dimensional structure was from PubChem National Center for Biotechnology Information (NCBI). This study was performing using AutoDock Vina 1.1.2 to analyze the binding affinity. Molecular modification was performed with Autodock Tools 1.5.6. Visualization was done with Chimera 1.10 and PyMol 1.3. Results: The docking scores between hepcidin and Anticalin was -4.6 kcal/mol at Cys13,Cys14, Arg16, and Ser17. The compound Roxburghine B and Oxoxylopine could interact with the ligand binding domain and had the docking scores lower than Anticalin. Conclusions: Roxburghine B and Oxoxylopine are potential to become hepcidin antagonists insilico for inflammatory anemia. Keywords: anemia inflamasi, phytochemical, molecular docking, hepcidin, Anticalin
Efek Proteksi Ekstrak Buah Naga Putih (Hylocereus undatus) terhadap Jumlah Sel Spermatid Mencit (Mus musculus) yang Dipapar Asap Rokok Wida Pratiwi Oktavia; Muthmainah . .; Yulia . Sari
Nexus Biomedika Vol 2, No 3 (2013): Nexus Biomedika
Publisher : Nexus Biomedika

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (13.862 KB)

Abstract

Background: White dragon fruit (Hylocereus undatus) contains vitamin C, E, A and polyphenol as antioxidant. This study aimed to prove the effects of white dragon fruit to to increase number of mice spermatids that exposured by cigarette smoke and to know what the effect of the increasing dose of the extract to the number of mice spermatid. Methods: This study was an experimental laboratory research with the posttest only control group design. The subject of this research were 28 male Swiss Webster mice (Mus musculus), aged 812 weeks and 20 grams weight. The subjects were arranged by incidental sampling into 4 groups that each group consisted of 7 mice. The negative control group (KKn) was adminstered aquadest while the positive control group (KKp) was exposured by cigarette smoke. The first treatment group (KP1) and the second treatment group (KP2) was successively administered 70 mg and 140 mg white dragon fruit extract per 20 g body weight. Two hours later, the subjects in KP1 and KP2 were exposured to cigarette smoke. This treatments were conducted for 14 days. On day 15th, subjects were sacrificed with neck dislocation and both testicles were stained with HE for microscopy study. The data were analyzed with Kruskall-Wallis test and Mann-whitney test (?=0.05) Results: Mean of spermatids mice in KKn, KKp, KP1 and KP2 were 358.2916.222; 241.1436.953; 375.7974.785; and 436.1433.629, in a row. Kruskall-Wallis test showed that the significance value was 0.000 (p <0.05). Mann-Whitney test showed significant differences between KKn-KKp, KKn-KP2, KKp-KP1, KKp-KP2, KP1-KP2 and no significant difference between the KKn - KP1. Conclusion: The white dragon fruit extract inhibited the number of damage spermatids of mice that exposured by cigarette smoke and the increasing doses of the extract enlarged the number of spermatids mice exposured by cigarette smoke Keywords: white dragon fruit extract, cigarettes, mice spermatid damage
Co-Authors Auliansyah Aldisela Januar Sukamto Mochammad Imron Awalludin RR. Ella Evrita Hestiandari Safirah . Yotriana Suyatmi . . Wida Pratiwi Oktavia Yuliana Heri Suselo