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Ganguly, Debgopal
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Medicine & Pharmacology

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A brief review on colon-specific drug delivery system for targeting to colonic region Ghosh, Soumyadip; Majumdar, Subhabrota; Ganguly, Debgopal
Journal of Applied Pharmaceutical Research Vol. 9 No. 4 (2021)
Publisher : Creative Pharma Assent

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18231/j.joapr.2021.9.15

Abstract

Drug delivery to the colonic region refers to the drug that should have to released in the colonic environment instead of released in the upper gastrointestinal tract. To reach the site-specificity of the local treatment of the colon such as amoebiasis, colorectal cancer, and inflammatory bowel disease the target-specific drug delivery played an important role. To the establishment of the target-specific drug delivery to the colon, the various approach that has been explored include pH-dependent polymer, time-dependent, and bacteria-dependent drug delivery approach. Nanotechnology has been gaining much more interest due to target specificity and enhancement of bioavailability and high loading capacity. In this review, oral nanoparticle formulation for colon targeting specifically inflammatory bowel disease and suitable drugs for useful treatment and future aspects of nanoparticle formulation with particular approaches to enhancement of drug stability in the gastric environment have been covered.
Current trends and future perspectives of natural polymer loaded nanoparticle based drug delivery system for the management of inflammatory bowel disease Basak, Ankita; Ghosh, Soumyadip; Ganguly, Debgopal; Garain, Soukat; Ghosh, Riya; Choudhury, Ananta; Deka, Himangshu; Sarmah, Jahnabi
Journal of Applied Pharmaceutical Research Vol. 11 No. 4 (2023)
Publisher : Creative Pharma Assent

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18231/j.joapr.2023.11.4.1.9

Abstract

Targeting the drug delivery system is very tough nowadays due to premature drug release at the upper GIT tract and altered pH conditions. Colon-specific drug delivery systems can overcome that problem using different polymer combinations. A nanoparticulate drug delivery system is the prominent dosage form that impacts the bioavailability and requires a low dose to excrete the therapeutic efficacy. All nanoscience and nanotechnology are applications of Nanometrology, the science of measurements at the nanoscale. NPDDSs were primarily developed to combine the colloidal stability of solid particle suspensions in biological fluids and the solubilizing properties of liquids. An ideal drug-delivery system possesses two elements: the ability to target and control the drug release. Colloidal drug carriers offer a number of potential advantages as delivery systems, such as better bioavailability for poorly soluble drugs. Researchers have created various sophisticated and multifunctional nanocarrier systems that can transport pharmaceuticals in a targeted, sustained, and regulated manner to provide therapeutic medications that are safer and more effective, particularly to ulcerative colitis. These innovative technologies are improving the pharmacokinetic profile of pharmaceuticals, increasing their systemic circulation, and decreasing the frequency of pharmacological side effects. The review focuses on the current trend and future perspectives of natural polymer-based-loaded nanoparticle-based drug delivery systems for the management of inflammatory bowel disease.
Co-Authors Ananta Choudhury, Ananta Basak, Ankita Deka, Himangshu Garain, Soukat Ghosh, Riya Ghosh, Soumyadip Majumdar, Subhabrota Sarmah, Jahnabi