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Integrative Analysis of the Pharmacological Activities of Lumbricus rubellus: Evidence from Preclinical and Clinical Research Hardiana, Iyan; Wahyudin, Elly; Aswad, Muhammad; Agustina, Rina
Borneo Journal of Pharmacy Vol. 8 No. 4 (2025): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v8i4.8741

Abstract

Lumbricus rubellus, commonly known as the red earthworm, has long been used in traditional medicine and contains diverse bioactive compounds with therapeutic potential. However, comprehensive and systematic evaluation of its pharmacological mechanisms remains limited. This review systematically analyzes the pharmacological activities of L. rubellus based on in vivo and clinical trial evidence to provide an integrated scientific understanding of its therapeutic potential. A systematic literature search was performed in PubMed, ScienceDirect, Wiley Online Library, Cochrane Library, and Google Scholar for studies published between 2013 and 2022. The review followed PRISMA 2020 guidelines, applying the PICOS framework for eligibility determination. Study quality was assessed using the ARRIVE checklist for in vivo studies and the JADAD scale for clinical trials. Twelve studies met the inclusion criteria, comprising nine in vivo and three clinical trials. Lumbricus rubellus demonstrated multiple pharmacological effects, including fibrinolytic, antibacterial, hepatoprotective, neuroprotective, and anticancer activities. These effects are mainly attributed to proteins such as lumbrokinase and coelomic fluid metabolites that exhibit antithrombotic, anti-inflammatory, and cytoprotective actions. This review highlights strong evidence supporting the diverse pharmacological activities of L. rubellus and its potential as a natural source for developing novel therapeutic agents. Further standardized clinical investigations are required to confirm its efficacy and safety.
Co-Authors . Hasbunallah AS Abd Halim Umar Abd. Haris Abdul Gaffar Haris abdul Rauf Sulaeman Abidah, Asiska Nur Adlan, Muhamad Aqim Ahmad Abbas Ahmad Budiman, Ahmad Ahmada, Muhamad Agus Alfiyan Nur Ahmed Sardi Aisyah Fatmawaty Ali H Ambo Lallo, Subehan Aminuddin Aminuddin Anwar Sewang Aqim Adlan, Muhammad Ardiansyah Ardiansyah Arsyad, Muhammad Aryadi Azizah, Irtifa Umi Bahktiar, Jusuf Barambangi, Jamil Burhan, Asril Dede Nurohman Deris Lazuardi Djabir, Yulia Yusrini Djalaluddin, Nurgadima Elly Wahyudin Febrianto, M. Nanang Firmansyah JN, Muh Fitriah, Reski Fortunasari, Fortunasari Gemini Alam Hajati, Kartika Hardiana, Iyan Hidayah, Arifah Rohmatul HIDAYAT, MARZUL Hijayati, Siti Sofiyah Hijra HM., Rahmaniah Hudain, Muh. Adnan Ikrar Taruna Syah, Ikrar Taruna IRMA YULIA MADJID, IRMA YULIA Kamil, Dairabi Kasim, Athia Kurnia Khaerati, Rahma KHASANAH, KHOLIFATUL Latif, Wenry Deston Latifah Rahman Lestari, Anggita Della Lestari, Lisa Yuni Linawati, Diana Lomba Sultan M. Nanang Febrianto Mappaompo, M. Adam Marianti A Manggau Matias N Kolobani Muh. Akbar Bahar Muh. Akbar Bahar, Muh. Akbar Muhamad Aqim Adlan Muhammad Arsyad Muhammad Syahrul Hidayat Mulia Ardi Mulyani, Ariny Aggreni Mustika Nur Astuti Nur Adyla S Nur Iman Saal Nur Zamzam Nurchalis, Nur Fadillah Nurdina Rasjid Nurrohman, Dhika Nursal, Muhammad Akbar Nursamsiar Nursamsiar Oftafiana, Triya Prasojo, Hendris Agung Pratiwi, Putri Hidayanti Putri, Dwi Anggara Rafiqa Rafiqa Raida Asfihana Ramadhani, Nur Rina Agustina Risfah Yulianti Risfah Yulianty Rohmah, Siti Lailatur Rokhmat Subagiyo Rokhmat Subagiyo, Rokhmat Rusdiah Salsabila, Chairunnisa Santoso, Irvan Widi Singh, Amreet Kaur Jageer Sohrah Sohrah, Sohrah Sutikno, Johan Dwi Syamsiyah, Siti Itsna Syamsu Nur, Syamsu Tadjuddin Naid Tumigolung, Aprilia Ester Eunike Utami, Rahmawati Ning Utoro, Bambang Wahyu Hendrarti Yasir, Budiman Yensawai E. Rumbiak Yudi Azis Yusnita Rifai, Yusnita