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All Journal Jurnal Kedokteran Indonesia Indonesian Journal of Medicine
Bella Lexmita Dorra
Universitas Airlangga
Medicine & Pharmacology Public Health

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Aktivitas Antimikroba Fraksi-Fraksi Dari Ekstrak Jamur Endofit Cladosporium oxysporum Yang Diisolasi Dari Aglaia Odorata Lour Sugijanto, Noor Erma; Dorra, Bella Lexmita
Jurnal Kedokteran Indonesia Vol 3, No 1 (2012)
Publisher : Jurnal Kedokteran Indonesia

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Abstract

Background:Some endophytic fungi have shown economicpotentials for future  production of enzyme, medicine, and biological control agent. This study aimed to examine the antimicrobial activities in ethyl acetate extract fractions of Cladosporiumoxysporumendophyticfungi against Escherichia coli, Staphylocooccusaureus,and Candida albicans. Method: Cladosporiumoxysporumendophyticfungi  was isolated from AglaiaodorataLour (pacarCina, Java)which was collected at Purwodadi Botanical Garden, Pasuruan, East Java. C. oxysporum were cultivated, extracted and fractionated. The fractions then were applied to antimicrobial activity assay. Disc diffusion method was conducted with 2 mg/disc concentration extracts. Results: The ethyl acetate extract fractions of C.oxysporumshowed antimicrobial activities against the three microbes tested. Six of 13 fractions exhibited inhibition zone against S. aureus ATCC 6538, E. coli ATCC 8739 and C. albicans ATCC 10231. The seventh fraction exhibited the highest inhibition zone against S. aureus ATCC 6538, and C.albicans ATCC 10231. The tenth fraction exhibited the highest inhibition zone against E. coli ATCC 8739. Conclusion:Cladosporiumoxysporum from Aglaiaodoratais a good source of antimicrobial substance.The discovery of bioactive metabolites in C.oxysporumendophytic fungi allows the development of a new antimicrobial medicine for commercial use. Key words:Cladosporiumoxysporum,endophytic fungi, AglaiaodorataLour,antimicrobial activity
Antimicrobial Activity of Cladosporiumoxysporum Endophytic Fungus Extract Isolated From Aglaiaodorata Lour Sugijanto, Noor Erma; Dorra, Bella Lexmita
Indonesian Journal of Medicine Vol 1, No 2 (2016)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

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Background: Endophytic fungi have econo­mi­c potential as enzymes, medicines and biological control agents. Cladosporiumoxysporum endophytic fungi can be isolated from a plant named Aglaia­o­dorata Lour (Indonesian: Paca rCina). This plant can be found inPurwodadi Botanical Garden, Pasu­ruan, East Java. This study aimed to assess the antimicrobial activity from the ethyl ace­tate extract of the Cladosporiumoxysporum endophytic fungi against Escherichia coli, Staphylo­coc­cu­saureus, and Candida albicans.Subjects and Method: This was a descriptive study. C. oxysporum was cultivated, extracted, and fractionated. The fractions then were applied to antimicrobial activity assay. Disc diffusion method was used in this project with 2 mg/disc concentration extracts.Results: Some fractions of ethyl acetate extracts C. oxysporum showed anti­mi­cro­bial activity against all microbials tested. 6 of 13 fractions exhibited inhibition zone against S. aureusATCC 6538, E. coli ATCC 8739, and C. albicansATCC 10231. The seventh fraction exhibited the highest inhibition zone against S. aureusATCC 6538, and C.albicans ATCC 10231.The tenth fraction exhibit  ed the highest zone against E. coli ATCC 8739.Conclusion: Cladosporiumo­xysporum from Aglaiaodorata could be a good source of anti­microbial substance.It produces bioactiveagent that can be developed into a new drug at a larger commercial scale.Keywords: endophytic fungi, cladosporiumn oxysporum, aglaiaodorata lour, antimicrobial activityCorrespondence: Noor Erma Sugijanto, Bella Lexmita Dorra. Faculty of Pharmacy, Airlangga University.Indonesian Journal of Medicine (2016), 1(2): 108-115https://doi.org/10.26911/theijmed.2016.01.02.04
Co-Authors Noor Erma Sugijanto