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Saefudin Saefudin
Research Center for Biology – Indonesian Institute of Science. Bogor
Agriculture, Biological Sciences & Forestry

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Journal : Indonesian Journal of Forestry Research

 1 
EFFECT OF SAPPAN WOOD (Caesalpinnia sappan L) EXTRACT ON BLOOD GLUCOSE LEVEL IN WHITE RATS Saefudin Saefudin; Gunawan Trisandi Pasaribu; Sofnie Sofnie; Efrida Basri
Indonesian Journal of Forestry Research Vol 1, No 2 (2014): Indonesian Journal of Forestry Research
Publisher : Secretariat of Agency for Standardization of Environment and Forestry Instruments

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (193.078 KB) | DOI: 10.20886/ijfr.2014.1.2.109-115

Abstract

Sappan wood or kayu secang (Caesalpinia sappan L.) was reported of having medicinal properties, such as natural antioxidant, relieve vomiting of blood, and mix of ingredients for malaria drugs. The research was conducted to study the influence of ethanol extract from sappan wood on blood glucose level of white rats. The study of the blood glucose level in rats was carried out by using glucose tolerance method. It was measured by Refloluxs (Accutrend GC) with Chloropropamide 50 mg/200 g BW (Body weight) as positive control. The ethanol extracts were used in various concentrations 10, 20, 30, 40 and 50 mg/200 g BW per-oral and was observed every hour, beginning one hour before to 7 hours after the extract being administered. The results showed that treatment of ethanol extract of sappan wood by administer doses gave remarkable effect on the blood glucose level in white rat. It reduced the glucose level in the blood compared to the negative and positive control. Treatment of dose 30 mg/200 g BW gave similar effect to positive controls, while a dose of 50 mg/200 g BW gave lower blood glucose level (93 mg/dl) than the positive controls.
ANTIOXIDANT ACTIVITY AND TOXICITY EFFECT OF ELEVEN TYPES OF BARK EXTRACTS ACQUIRED FROM EUPHORBIACEAE Saefudin Saefudin; Efrida Basri; Agus Sukito
Indonesian Journal of Forestry Research Vol 5, No 2 (2018): Indonesian Journal of Forestry Research
Publisher : Secretariat of Agency for Standardization of Environment and Forestry Instruments

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (313.236 KB) | DOI: 10.20886/ijfr.2018.5.2.133-146

Abstract

The use of natural antioxidants for medicinal purposes deserves thorough attention for their efficacy and possibly adverse toxicity. This paper studies the antioxidant actions and toxicity effects of bark extracts. The study focuses on eleven tree species of Euphorbiaceae family. Initially, bark samples from those trees were extracted using ethanol. The acquired extracts were examined for peroxide values with iodometric method. The bark extracts were chemically screened for possible antioxidant-compound contents, i.e. polyphenols, flavonoids, and saponins; and followed by oxidation-reduction test to assess the extract ability in vitro to scavenge free radicals in their standard sources, i.e. 2,2-diphenyl-1-picrylhydrazyl; altogether to determine qualitatively which species origin from bark extracts afforded the most potential as antioxidants. Toxicity test was performed on those bark extracts to assess their safety on living creatures, particularly humans as tried on shrimp larvae by counting their death, using the Brine Shrimp Lethality Test method. Results show that bark extracts of four plant species, i.e. Acalypha hispida Blume, Bischofia javanica Blume, Glochidion arboreum Blume and Sapium baccatum Roxb species afforded potentiality as antioxidants, because its peroxide value (POV) was lower than or somewhat above those of the positive control vitamin E (POV 89.45 μg/ml). However, bark extracts from Euphorbia antiquorum  L, Euphorbia hirta L, and Jatropha podagrica Hook (i.e. LC50 : 238.85; 228.11 & 194.51 μg/ml) were highly toxic, because their LC50’s value< 1000 μg/ml.
Co-Authors Agus Sukito Efrida Basri Efrida Basri Gunawan Trisandi Pasaribu Sofnie Sofnie