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Kadek Joni Prayoga
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Chemistry Dentistry Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology

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STUDI PENGARUH BAHAN TAMBAHAN PADA POLA PUNCAK KROMATOGRAM TABLET PARASETAMOL DENGAN TLC-SPEKTROFOTODENSITOMETRI UNTUK DRUG PROFILING Kadek Joni Prayoga; Ni Putu Linda Laksmiani; I Nengah Kadjeng Widjaja
Indonesian Journal of Legal and Forensic Sciences (IJLFS) Vol 5 (2015): Indonesian Journal of Legal and Forensic Sciences
Publisher : Penerbit, sejak 2012 : Asosiasi Ilmu Forensik Indonesia dan UPT Lab. Forensik Sain dan Kriminilogi - Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/IJLFS.2015.v01.i01.p04

Abstract

The study of chromatogram peak pattern by influence of excipient in paracetamol tablet with TLC- Spectrophotodensitometry method for drug profiling has been done. Sample (6 kind of paracetamol tabletsfrom different factory) and reference compounds were analyzed with TB (cyclohexane : toluene:diethylamine = 75:15:10) and TAEA (toluene : acetone : ethanol: ammonia = 45:45:7:3) as mobile phase andAl-TLC Si 60 G F254 as stationary phase.The initial step was non analyte peak reduction on Al-TLC plate with washing method, drying time and temperature variation. Sample was extracted with 1 ml chloroform and Na2CO3 buffer pH 10 and spotted onAL-TLC plate. First, sample extract from same factory was spotted on one plate, continued by sample extractfrom 6 different factories on one plate which is replicated five fold on each plate that different. Plate was eluted and scanned at 210 nm. Chromatogram was analyzed by cosine and cluster function. C95 value thatwas calculated from sample was used as a parameter to determine the influence of excipient towardchromatogram peak pattern.The result of this research showed that each tablet from same factory gave C95 value near 100 if calculated with cosine function (96 - 98,7 for TB and 78 - 83 for TAEA), whereas if all tablets from 6different factories was used, the excipient from each tablet will give C95 value alteration (63 for TB and 68 for TAEA). Cluster analysis will divide sample into 3 different groups for TB and 1 group for TAEA.
Co-Authors I Nengah Kadjeng Widjaja Ni Putu Linda Laksmiani