Garuda - Garba Rujukan Digital

Eko Suhartono

University of Lambung Mangkurat

Author-ID : 3109083

Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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IMPACT OF HEAVY METALS ON HEXOKINASE ISOFORMS: AN IN SILICO STUDY Ellen Ayuningtyas Pratidina; Eko Suhartono; Bambang Setiawan
Berkala Kedokteran Vol 18, No 1 (2022)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Abstract: Coal mining activities in South Kalimantan produce waste that is very dangerous if not processed wisely. Coal waste produces heavy metals cadmium and mercury that can pollute the environment. Heavy metals that enter the human body will cause negative impacts in the field of health such as the disruption of the glycolysis process in humans. The purpose of this study was determine the interaction of heavy metals which is cadmium and mercury against hexokinase enzymes using hexokinase enzymes type I, II, III with PDB ID : 4F9O, 2NZT, 3HM8 taken from Protein Data Bank and using the molecular docking website MIB: Metal Ion Binding Site Prediction and Docking server. Docking results will be visualized using chimera app version 1.15. Molecular docking of the heavy metals cadmium and mercury can interact with all three types of hexokinase enzymes. Cadmium metal ions bind hydrophobicly to amino acid residues of hexokinase enzymes type I, II, and III, while mercury metal ions bind covalently coordinate with amino acid residues of hexokinase enzymes type I and III. Mercury metal ions bind more strongly than cadmium metal ions. Of the three types of hexokinase enzymes, mercury metal ions bind most strongly with hexokinase enzyme type II because mercury ions bind to the active site of the three amino acid residues of hexokinase enzymes type II.Keywords: Cadmium ; hexokinase enzyme ; mercury ; molecular docking

Obstetrical and Non-Obstetrical Factors toward Uterine Prolapse Occurrence in Ulin General Hospital Banjarmasin on Januari – December 2017 Yohanes Adhitya Prakasa Sukoco Putra; Eko Suhartono; Pribakti Budinurdjaja
Berkala Kedokteran Vol 15, No 1 (2019)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Abstract: Uterine prolapse is a gynecological disease in women that emerge patients physically and psychologically. Uterine prolapse is defined as an uterus herniation inside or outside vagina as the result of the ligament and fascia failure that retain the uterus in its actual place. This research was to identify obstetrical and non-obstetrical factors in uterine prolapses occurrence in Ulin General Hospital Banjarmasin on period January until December 2017 using case control approach. The total sample was 80 medical record samples, which divided into 40 medical record samples of patient with uterine prolapse and 40 medical record samples of patient without the occurrence of uterine prolapse. The results using chi square analysis obtained non-obstetrical factors: age >60 years old (OR 6.67: 95%CI 2.44-18.21), BMI > 30 (OR 3.10: 95%CI 1.24-7.71), menopause (OR 21.00: 95%CI 6.11-72.18); and non-obstetrical factors: parity >4 / multiparity (OR 13.78: 95%CI 4.71-40.28), macrosomia (OR 7.15: 95%CI 2.65-19.34), vaginal delivery (OR 28.78: 95%CI 7.41-111.79). The results of logistic regression obtained non-obstetrical factors: age > 60th (Exp B 4.21 and sig. 0.004), menopause (Exp B 1.12 and sig. 0.001), and multiparity (Exp B 2.35 and sig. 0.016). The results of this analysis obtained that obstetrical and non-obstetrical factors were related to uterine prolapse occurrence, and the dominant factor was age > 60 years old, so it could be concluded that there was significant factor between obstetrical and non-obstetrical factors on uterine prolapse occurrence in Ulin General Hospital Banjarmasin. Keywords: uterine prolapse, obstetrical factor, non-obstetrical factor

Hesperidin Interaction with HMG-CoA-Reductase Enzyme in Hypercholesterolemia: A Study in Silico Annisa Rizqi Dwi Oktaviani; Veronica Shania Aprillia; Eko Suhartono; Noer Komari
Berkala Kedokteran Vol 17, No 2 (2021)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Abstract: Dyslipidemia is a degenerative disease occurred with increased levels of fat and cholesterol levels in blood. One of the proteins used as anti-cholesterol is an HMG-CoA-Reductase. Hesperidin in orange peel can reduce cholesterol levels by interacting with HMG-CoA-Reductase. To prove this, an in silico method was used by using swissdock.ch (http://swissdock.ch/docking#). The receptor protein in dyslipidemia was obtained from the RCSB Protein Data Bank (https://www.rcsb.org) namely HMG-CoA-reductase receptor with code PDB: 1HW9. The natural ligand, hesperidin, was obtained from PubChem with code: 10621 (https://pubchem.ncbi.nlm.nih.gov/). Protein was prepared by omitting the natural ligand residues present in the protein. Ligand and protein preparations were used by the chimera 1.15. The result of this study indicated that the interaction of hesperidin with several amino acid recidues was predicted to provide inhibitory activity on HMG-CoA reductase as the protein target. Inhibition of HMG-CoA reductase will reduce mevalonate synthesis so that cholesterol levels will decrease. Keywords: hesperidin, HMG-CoA-Reductase, cholesterol, dyslhahipidemia

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