<![CDATA[Introduction: Autonomic dysfunction is one of the non-motor symptoms of parkinsonism but has not been of clinical concern. The purpose of this study was to assess the relationship of autonomic dysfunction with the severity of parkinsonism patients.Method: A total of 121 outpatient subjects in the Neurology Clinic of Prof. Dr. R. D. Kandou Hospital Manado, sample selection is done consecutively in analytic cross-sectional studies. The patient characteristics, symptoms and examination of autonomic dysfunction are recorded. Data were analyzed using chi square, Mann Whitney U, Kruskal-Wallis and logistic regression. Result: Almost all variables measuring autonomic function tended to show a higher degree of severity of parkinsonism (p < 0.001). Each increase in the SCOPA-AUT INA score tends to increase the odds of the Hoehn and Yahr stage (OR > 1) also in the greater orthostatic blood pressure difference test, older age, longer illness, longer treatment period, and use of a combination of antiparkinson drugs.Conclusion: Autonomic dysfunction is significantly related to the severity of parkinsonism.]]>
