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All Journal JKPK (Jurnal Kimia dan Pendidikan Kimia)
Yesaya Reformyada Nusantoro
Department of Chemistry, Faculty of Science and Data Analytics, Institut Teknologi Sepuluh Nopember Jl. Teknik Mesin No.175, Keputih, Sukolilo, Surabaya, East Java 60115
Chemical Engineering, Chemistry & Bioengineering Chemistry

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The Effect of Energy Minimization on The Molecular Docking of Acetone-Based Oxindole Derivatives Arif Fadlan; Yesaya Reformyada Nusantoro
JKPK (Jurnal Kimia dan Pendidikan Kimia) Vol 6, No 1 (2021): JKPK (Jurnal Kimia dan Pendidikan Kimia)
Publisher : Program Studi Pendidikan Kimia FKIP Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/jkpk.v6i1.45467

Abstract

In silico study by molecular docking, drug discovery, and virtual screening are useful for obtaining compounds with promising biological activity. The force fields energy minimization in molecular docking is the overall process to produce better geometry estimation and ligand-receptor affinity. In this study, the divide and conquer algorithm based on the Mikowski matrix in MarvinSketch and the conjugate gradient algorithm of Open Babel were used to minimise acetone-based oxindole derivatives in indoleamine 2,3-dioxygenase 1 (IDO1). The results showed that the binding energy produced by MarvinSketch was generally better than the binding energy obtained with Open Babel. The visualization of molecular docking results indicated that the poses and hydrogen bonding, halogen bonding and π-π interactions are different between MarvinSketch, Open Babel, and no energy minimization. The results revealed that energy minimization affects the molecular docking results. 
Co-Authors Fadlan, Arif