Distribution is an important aspect of industrial activity to serve customers on time with minimal operational cost. Therefore, it is necessary to design a quick and accurate distribution route. One of them can be design travel distribution route using the k-means method and genetic algorithms. This research will combine k-means method and genetic algorithm to solve VRPTW problem. K-means can do clustering properly and genetic algorithms can optimize the route. The proposed genetic algorithm employs initialize chromosome from the result of k-means and using replacement method of selection. Based on the comparison between genetic algorithm and hybrid k-means genetic algorithm proves that k-means genetic algorithm is a suitable combination method with relative low computation time, are the comparison between 2700 and 3900 seconds.