Article Per Year (5 Year)
p-Index From 2021 - 2026
0.444
P-Index
This Author published in this journals
All Journal Microbiology Indonesia Jurnal Biodjati Tropical Genetics
MAELITA RAMDANI MOEIS
Unknown Affiliation
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Earth & Planetary Sciences Immunology & microbiology Medicine & Pharmacology

Published : 4 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 1 Documents
Search
Journal : Tropical Genetics

 1 
Identification of single nucleotide polymorphisms on the D-loop region of mtDNA in Sundanese population Wolly Candramila; Sony Heru Sumarsono; Bambang Suryobroto; Maelita Ramdani Moeis
Tropical Genetics Vol. 1 No. 1 (2021)
Publisher : Genetikawan Muda Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Identification of sequence polymorphism on the D-loop region of mtDNA has been done for various purposes, including health and medical treatment. In this research, single nucleotide polymorphisms were identified in the D-loop region of mtDNA of the Sundanese population in western Java. A total of 118 unrelated and healthy Sundanese probands were collected from closed-traditional kampung adat and open communities distributed in 14 cities and regencies in western Java. DNA amplification and direct sequencing of the D-loop region were proceeded using primers L15990 and H409. Multi-alignment was conducted not only intrapopulation but also with D-loop sequence data stored in GenBank for comparison. In this research, we categorized high-frequency SNPs as less effective for identification in population studies because of their presence in other populations outside Indonesia. Meanwhile, lower-frequency SNPs showed typical variants of Sundanese haplotypes. On the other hand, rare or low-frequency SNPs should be re-examined in larger size of samples to have a better understanding of risk factors for many diseases.
Co-Authors Aila Gema Safitri Anisa Nurul Huda ARI DWIJAYANTI Arifa Nadya Nur Afifah ARUM PATRIATI Bambang Suryobroto DESSY NATALIA EDY GIRI-RACHMAN PUTRA ERNAWATI ARIFIN GIRI-RACHMAN FENRYCO PRATAMA IHSANAWATI IHSANAWATI Linda Pertiwi Muhammad Farid Maksum Nisa Ihsani Oktira Roka Aji RAHMA WIDYA NINGRUM SONY HERU SUMARSONO Tiwi Sartika WOLLY CANDRAMILA