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All Journal Jurnal Riset Kefarmasian Indonesia Jurnal Ilmiah Medicamento
Hayatus Sa`adah, Hayatus
Faculty of Pharmacy, Universitas Gadjah Mada. Yogyakarta, Indonesia.
Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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AKTIVITAS ANTIBAKTERI EKSTRAK AIR KULIT BAWANG MERAH (Allium cepa L.) TERHADAP BAKTERI Propionibacterium acnes Sa`adah, Hayatus; Supomo, Supomo; Musaenah, Musaenah
Jurnal Riset Kefarmasian Indonesia Vol. 2 No. 2 (2020): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v2i2.73

Abstract

Propionibacterium acnes is one of the causes of acne. Shallot peels contain flavonoids, tannins, and saponins which potentially have antibacterial activity. The purpose of this study was to determine whether the water extracts of shallot peels have antibacterial activity against Propionibacterium acnes and determine the concentration which can inhibit the growth of bacteria Propionibacterium acnes. This research is an experimental study. The research stage begins with the extraction of shallot peels using in the foundation. Antibacterial activity was tested using the diffusion method with the Cup-plate technique. Propionibacterium acnes used as a sample of bacteria, with extract concentrations of 5%, 10%, 20%, and 40%. Positive controls used are clindamycin 150 mg and negative controls were used dimethyl sulfoxide 1% (v / v). Data were analyzed with a statistical test of the Kolmogorov-Smirnov method. The measurement results inhibition zone of shallot peels water extract with a concentration of 5%, 10%, 20%, and 40% of the bacteria Propionibacterium acnes sequentially by 12.8 mm, 13 mm, 14.33 mm and 15.50 mm in the strong category. The measurements of bacterial growth inhibition zone were statistically analyzed with the Kruskal-Wallis method gained 0,053 results indicating that the test has a significant effect (P > 0.05) with a decision that means that there is no significant difference between all concentrations.
Optimization Of Tablet Formulation of Ethanol Extract of Basin (Ocimum basilicum L.) As Antioxidant with Variations of Pregelatinized Starch and Explotab Sa`adah, Hayatus; Sya’diyah, Halimatus; Ansyory, Achmad Kadri; Supomo, Supomo
Jurnal Ilmiah Medicamento Vol 12 No 1 (2026): Jurnal Ilmiah Medicamento (In progress)
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/medicamento.v12i1.12621

Abstract

Background: Basil (Ocimum basilicum L.) is recognized as a rich botanical source of secondary metabolites that exhibit notable antioxidant properties.Objective: The present investigation sought to examine how variations in disintegrant type and proportion—specifically pregelatinized starch and Explotab—influenced the physical characteristics and antioxidant capacity of tablets prepared from basil leaf ethanol extract.Methods: Three distinct formulations were developed based on differing pregelatinized starch-to-Explotab ratios: Formula I (0:1), Formula II (1:1), and Formula III (1:0). All prepared tablets underwent comprehensive physical evaluation and stability assessment, while antioxidant potential was quantified through the DPPH radical scavenging method. The formulation optimization process employed the Simplex Lattice Design (SLD) methodology executed via Design-Expert® version 13 software.Results: Experimental findings demonstrated that the ratio variation between pregelatinized starch and Explotab exerted measurable effects on both granule and tablet physical attributes. Specifically, pregelatinized starch was found to predominantly elevate bulk density, weight uniformity, and disintegration time, whereas Explotab exhibited a stronger regulatory influence over moisture content, flow rate, Carr’s index, and tablet friability. The optimal formulation was identified as containing 6.72% pregelatinized starch combined with 1.27% Explotab. Notably, all three formulations demonstrated very strong antioxidant activity, with IC₅₀ values spanning from 33.78 to 39.52 ppm. One-way ANOVA statistical evaluation revealed no significant interformulation differences (p > 0.05).Conclusion: The collective data supports the conclusion that a strategic combination of pregelatinized starch and Explotab yields basil extract tablets with satisfactory physical quality alongside preserved antioxidant efficacy.
Co-Authors Ansyory, Achmad Kadri Musaenah, Musaenah Supomo Supomo Sya’diyah, Halimatus