This paper discusses the environmental impact on human health through various concepts including Islamic thinking. Thus, the human environment relationship was defined from different perspectives; science, philosophy, and Al-Qur'an. The natural environment, human, and health were defined the same way. For more obvious description of the relationship between human and nature and its impact on people’s health, a comparison between the environmental factors affecting human health and the human activities impact on environment was carried out.Keywords: Environment, Human, Health.