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R. Mustarichie
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Medicine & Pharmacology

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Variation of Nicotine Metabolism in Adult Men in the Jakarta Clinical Laboratory R. Mustarichie
Journal of Global Pharma Technology Volume 12 Issue 01
Publisher : Journal of Global Pharma Technology

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Abstract

Objective: Nicotine, a mayor addictive constituent of tobacco plays a critical role in smoking addiction.  Nicotine is primarily metabolized to cotinine. The objective of the research was to determine the variation of Nicotine metabolism in adult men in the Jakarta Clinical Laboratory. Methods: The research was done to 27 men aged 19-45 years old, which consisted of 6 smokers and 21 nonsmokers. Nicotine and cotinine of the plasma concentration 2 hours after chewing one piece of nicotine gum were determined by Liquid Chromatography-Mass Spectrometry (LC-MS) method. Results: The cotinine/nicotine ratio of the plasma concentration was calculated as an index of nicotine metabolism. Scatter plot cotinine/nicotine ratio of showed distribution heterogeneous (not homogeneous).Conclusion: It could be concluded that variation nicotine metabolism could be categorized to light nicotine metabolism (<0, 22), medium (0, 22 - 4, 19), and heavy (> 4, 19).Keyword: Nicotine metabolism, Cotinine/nicotine ratio.
Anredera Cordifolia Leaves Sub-fraction as Anti Hyperlipidemia R. Mustarichie
Journal of Global Pharma Technology Volume 12 Issue 06 (2020) June 2020
Publisher : Journal of Global Pharma Technology

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This study aimed to evaluate the anti-hyperlipidemic properties of the sub-fraction of the Binahong (Madeira vine, Anredera cordifolia) extract in male Wistar rats. The rats were given high-fat food every day for 3 months and pure cholesterol on weeks 0, 3, 7, and 11. Furthermore, Ethyl acetate sub-fraction of binahong leaves with 0, 12 mg/kg BW, and 0, 24 mg/kg BW doses were given orally for 3 weeks and observed for lipid profile on day 21. The result showed that sub-fractions of Madeira vine leaves decreased in triglyceride, cholesterol, and low-density lipoprotein (LDL) levels and did not influence the high-density lipoprotein level (HDL). Meanwhile, statin decreased total triglyceride, cholesterol, and the LDL level, and increased the HDL level. It concluded that Madeira vine sub-fraction with 0, 24 mg/kg BW dose presented improved results in the lipoprotein profile. Keywords: Binahong, Madeira vine, Anredera cordifolia, hyperlipidemia, ethyl acetate fraction
Evaluation of Nucleated Red Blood Cell Morphology Flag Screening with ADVIA® 2120 R. Mustarichie
Journal of Global Pharma Technology Volume 12 Issue 06 (2020) June 2020
Publisher : Journal of Global Pharma Technology

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The evaluation of nucleated red blood cell morphology flag screening with ADVIA® 2120 on behalf of blood smear has been investigated. The accurate and timely reporting of nucleated red blood cells (NRBC) is an important function of the clinical hematology laboratory because the presence of NRBC in human peripheral blood can show a special clinical status. It has been used 40 samples to evaluate an NRBC screening for the ADVIA® 2120 Hematology System with peripheral blood smears. The positive samples have a criteria % NRBC in range 0 – 15%. (in 100 leucocytes). The sensitivity and specificity for the presence of NRBC for all samples analyzed was 90 % and 63,33 %, respectively. There is a correlation on NRBC result screening between ADVIA® 2120 and peripheral blood smears with α 0,003 of spearman correlation. Keywords: Nucleated red blood cell (NRBC, flag, Clinical test, ADVIA® 2120.
The Relationship between Blood Pressure with P-Selectin in Indonesian Hypertension Patients R. Mustarichie
Journal of Global Pharma Technology Volume 11 Issue 08 (2019) Aug. 2019
Publisher : Journal of Global Pharma Technology

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Objective: The involvement of vascular inflammation is shown in the initiation and development of hypertension. P-selectin plays an important role in the inflammatory response through the initiation of leukocyte adhesion in platelets and endothelial cells. The purpose of this research was to determine the relationship between blood pressure and P-selectin in Indonesian hypertensive patients. Methods: The cross-sectional design study was conducted in 56 patients with hypertension, aged 40 to 60 years, blood pressure and serum P-selectin (sP-selectin) concentration measured. sP-selectin was determined by a colorimetric ELISA sandwich. Interpretation of the relationship between blood pressure components and sP-selectin concentration was carried out by statistical analysis. Results: It was found that sP-selectin level did not correlate significantly with systolic blood pressure (r = 0.078; P = 0.568), diastolic blood pressure (r = -0.014; P = 0.921), mean arterial pressure (r = 0.062; P = 0.648), and pulse pressure (r = 0.062; P = 0.648). Conclusion: Our results concluded that the increase in blood pressure components was not significantly associated with an increase in circulating sP-selectin concentration in hypertensive patients. Thus, there was no significant correlation between blood pressure and P-selectin in hypertensive patients. The tendency of positive results indicated an inflammatory involvement in hypertension.Keywords: Blood pressure, P-selectin, hypertension, Vascular inflammation adhesion, ELISA.
In-silico Screening of Compounds Contained in Wera (Malvaviscus Arboreus Cav.) Leaves as Anti-alopecia with Androgen Receptors R. Mustarichie
Journal of Global Pharma Technology Volume 11 Issue 6.
Publisher : Journal of Global Pharma Technology

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Objective: Baldness (Alopecia) is a serious problem at this time because it is caused by stress, genetic factors, pregnancy, inadequate hair care, and less balanced nutrition. Previous studies have shown that ethanol extracts of Wera leaves (Malvaviscus arboreus) have anti-baldness properties. Research study was undertaken to investigate the potential of chemical compounds contained in the leaves of Wera as hair growers using androgen receptors with comparative drugs Minoxidil. Methods: This type of research is in silico where the results obtained are free energy values and hydrogen bonds that connect ligands with receptors. Results: From the 7 compounds contained in the Wera leaf, the results showed that trifolin compounds gave the lowest energy -7.08 kcal/mol and amino acids that were bound were Thr (877), Asn (705), and Phe (764) where more than the comparative drug Minoxidil namely Leu (873) and Asn (705) with free energy is -5.81 kcal/mol. In predicting pharmacokinetic properties and toxicity tests, compounds that are predicted as candidates for hair growth drugs do not meet pharmacokinetic parameters and are non-mutagenic and not carcinogenic so they cannot be administered orally. Conclusion: It is found that molecules with compounds 2- [2- (5-methyl-2-propane-2-ylphenoxy) ethoxy] naphthalene-1-carboxylate provides the lowest energy, which is -9.47 kcal/mol so that it has the potential to be a candidate for a new drug in the treatment of hair growth, namely alopecia either oral or topical usedKeywords: Wera leaves, In-Silico, Hair growers, Androgen receptors, Malvaviscus arboreus.
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