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Toji Thomas
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Medicine & Pharmacology

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Journal : Journal of Global Pharma Technology

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Reliminary Antibacterial and Phytochemical Evaluation of Dryopteris Cochleata (D.DON) C.CHR Toji Thomas
Journal of Global Pharma Technology Volume 03 Issue 06: (2011) June 2011
Publisher : Journal of Global Pharma Technology

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Abstract

Ryopteris cochleata Dryopteridaceae is one of the important plants of traditional systems of medicine. Fronds (leaves) of Dryopteris cochleata were evaluated for its antibacterial potential and phytochemical contents in various solvent extracts in increasing polarity towards pathogenic bacterial species. Antibacterial activity was tested by disc diffusion method. Petroleum ether, acetone, methanol and water extracts of Dryopteris cochleata were tested for antibacterial activity towards some pathogenic bacterial strains. Both acetone and methanol extracts exhibited antibacterial activity; maximum activity was shown by acetone extract compared to others. Antibacterial activity was confirmed by minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC). MIC and MBC values of acetone extract of 12.5mg/ml and 25mg/ml were observed towards Staphyococcus albus while MIC and MBC values of 25mg/ml and 50mg/ml were observed towards Pseudomonas aeruginosa. Flavonoids, phenols, steroids were detected in acetone and methanol extracts. The study proves that Dryopteris cochleata possesses antibacterial principles, soluble in acetone, which hinder the growth and multiplication of some multidrug resistant bacterial strains. Keywords: Dryopteris cochleata, yopteridaceae, Tibacterial, Dsc diffusion.
Antibacterial Evaluation of Gradient Extracts of Adiantum latifolium Lam. Towards Pathogenic Cutaneous Bacteria Toji Thomas
Journal of Global Pharma Technology Volume. 9 Issue 6
Publisher : Journal of Global Pharma Technology

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Objective: The study focused to analyse antibacterial evaluation of gradient extracts of Adiantum latifolium, a healing pteridophyte towards bacteria involved in cutaneous infections. Methods: Whole plant of Adiantum latifolium was analyzed for its antibacterial nature and phytochemical components in different solvents extracts of accelerating polarity. Disc diffusion method was used to analyse antibacterial activity. Preliminary phytochemical evaluation was done using various spraying reagents. Minimum inhibitory concentration as well as minimum bactericidal concentration was determined towards Pseudomonas aeruginosa. Results: The plant primarily exhibited antibacterial activity in ethanol extract. Maximum intensity of activity was noticed towards Pseudomonas aeruginosa, a resistant strain towards amoxicillin and chloramphenicol. Petroleum ether and water extracts could not show any antibacterial activity towards the tested organisms. Flavonoids and phenols were found in different extracts. Occurrence of flavonoid and phenol in ethanol extract of the plant can be an explanation for its antibacterial activity. Ethanol extract of the plant showed minimum inhibitory concentration as 18.75mg/ml and minimum bactericidal concentration as 37.5mg/ml towards Pseudomonas aerogenosa. Conclusion: Adiantum latifolium showed antibacterial activity in ethanol extract especially towards   Pseudomonas aeruginosa. Adiantum latifolium; Antibacterial activity; Phytochemical; Pteridophytes.
Antibacterial Evaluation of Gradient Extracts of Stenochlaena palustris (Burm.f) Bedd. Towards Bacteria Involved in Skin Diseases Toji Thomas
Journal of Global Pharma Technology Volume 11 Issue 01 (2019) Jan. 2019
Publisher : Journal of Global Pharma Technology

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Objective: The work attempted to analyse the antibacterial character of gradient distillate of Stenochlaena palustris, a healing fern used to treat burn. The plant was evaluated for its antibacterial capability towards bacteria occupied in skin infections. Methods: Whole plant of S. palustris was examined for its antibacterial potential and phytochemical constituents in different solvents extracts of incrementing polarity. The typical disc diffusion method was done to inspect antibacterial activity. Basic phytochemcal assessment was accomplished by various standard spraying reagents and used to detect the same. Minimum inhibitory concentration and minimum bactericidal concentration were established towards Pseudomonas aeruginosa. Results: The plant could basically demonstrate antibacterial activity in acetone extract. P. aeruginosa was the most sensitive organism observed out of the tested bacteria. Water extracts did not provide antibacterial activity to the analysed bacteria. Phenols, flavonoids, polyphenols and sterols were track down in various extracts. Flavonoids, phenols, polyphenols and sterols found in acetone extract of the plant could be responsible for its antibacterial activity. Acetone extract of the plant yielded minimum inhibitory concentration as 12.5 mg/ml and minimum bactericidal concentration as 25.0 mg/ml towards P. aeruginosa. Conclusion: S. palustris manifested antibacterial activity in acetone extract notably towards   P. aeruginosa, a bacterium frequently associated with nosocomial infection. Keywords: Stenochlaena palustris, Antibacterial activity, Pteridophytes, Disc diffusion, Phytochemicals.
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