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RADHA krishnan meera
professor
Medicine & Pharmacology

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Journal : Journal of Global Pharma Technology

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Isolation, Purification and Structural elucidation of bioactive constituents from root bark of Crataeva magna Lour (DC) RADHA krishnan meera
Journal of Global Pharma Technology Volume 10 Issue 02: (2018) Feb 2018
Publisher : Journal of Global Pharma Technology

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Abstract

Objective: The study was to isolate and characterize the bioactive phytoconstituents from Crataeva magna Lour (DC).Materials and methods: For isolation of the compounds, ethanolic extract of Crataeva magna Lour (DC) isolated first with petroleum ether, increasing amounts of EtOAc in petroleum ether and finally with methanol yielded a number of fractions. The proportion of solvent systems used to obtain CM-01 and CM-02 were hexane-EtOAc (80: 20) and EtOAc –methanol (98:2) from fractions 5 and 8.Results: The subsequent structures of isolated compounds were elucidated by various spectrophotometric analysis. Mass spectrum of CM-01 and CM-02 showed a parent molecular ion (M+) peak at 382 gm/mol and 614 gm/mol respectively. In the 1H- NMR spectrum of CM-01  has 0.728 (methyl H), 2.439 (OH ), 2.764 (long chain CH2), 3.953(H in CH2 adjacent to OH ) where as in the 1H- NMR spectrum of CM-02, 3.9-4.2 (CH3 protons), 5.7 (OH group), 6.2-7.2 (Aromatic protons)Conclusion: From the physical, chemical and spectral characteristic CM-01 and CM-02 were concluded as phytosterols (Ceryl alcohol (Hexacosan -1-ol)) and macropolyphenol (Tannic acid).Keywords: Crataeva magna Lour (DC), phytosterols, macropolyphenol.  
Characterization and Evaluation of Antioxidant activity of Crataeva magna Lour (DC) RADHA krishnan meera
Journal of Global Pharma Technology Volume 09 Issue 09
Publisher : Journal of Global Pharma Technology

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Objective: The present study was designed to investigate the anti-oxidant activity of the ethanolic extract of Crataeva magna Lour DC. The root bark of Crataeva magna Lour DC belonging to family Capparaceae is used in anti spasmodic, hypotensive, anti-inflammatory, hypoglycemic, anti protozoal, analgesic purposes.Methods: The ethanolic extract was evaluated by TLC and the antioxidative potential of ethanolic extract of Crataeva magna Lour DC was evaluated using 1,1-Diphenyl-2-Picrylhydrazyl (DPPH), hydrogen peroxide and xanthine oxidase inhibition assay.Results: The ethanolic extract of Crataeva magna Lour DC exhibited highest level of antioxidant activities. The ethanolic extract of Crataeva magna Lour DC showed up to 76% inhibition of DPPH free radical at 517 nm at high concentration of 1 mg/ml. The in-vitro xanthine oxidase inhibition of root ethanolic extract revealed significant (69%) inhibitory activity at 30 µg/ml and it compared with the standard drug quercetin which showed 70% inhibition at 30 µg/ml. In hydrogen peroxide scavenging activity the test extract shows 26% of inhibition when compared to the standard ascorbic acid.Conclusion: The presence of strong antioxidant activity of ethanolic extract of Crataeva magna Lour DC can be a great scope for further studies on this plant regarding its antioxidant potentials.Keywords: Root bark of Crataeva magna Lour DC, TLC, Antioxidant activities. 
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