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All Journal Manilkara: Journal of Bioscience
Rizal Maarif Rukmana
National Research and Innovation Agency (BRIN) of Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Neuroscience Veterinary

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Journal : Manilkara: Journal of Bioscience

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Antibacterial Activity of Ethanolic Extract Siwak Stem (Salvadora persica) Against Staphylococcus aureus ATCC 25923 Nisa’ Nur Sholikhah; Andang Arif Wibawa; Rizal Maarif Rukmana
MANILKARA: Journal of Bioscience Vol 1 No 2 (2023): Februari
Publisher : LPPM Universitas Terbuka

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (332.08 KB) | DOI: 10.33830/manilkara.v1i2.4095.2023

Abstract

Infection is caused by bacteria, one of which is Staphylococcus aureus. Infectious treatment can use Siwak as natural plants (Salvadora persica), namely Siwak plants. Salvadora persica contains Saponins, Alkaloids, Tanins, and Fenols. This study is to know the antibacterial activity of Salvadora persica stems against Staphylococcus aureus ATCC 25923 growth. Extraction method using maceration with ethanol as a solvent. The group of extract compounds was identified using various chemical reagents. Salvadora persica stem extract was made in various concentrations of 6,25%, 12,5%, 25%, and 50% by using dimethyl sulfoxide 2% (DMSO) as thinner. Chlorhexidine 0,2% was a positive control, and DMSO 2% was a negative control. Antibacterial activity test was obtained by diffusion method. Analysis data used way ANOVA test. The results ethanolic extract of the siwak stem contains a class of compounds: saponins, alkaloids, tannins, and phenols. The result showed that Salvadora persica stem extracts antibacterial activity against Staphylococcus aureus ATCC 25923. Antibacterial activity test against Staphylococcus aureus from laboratory culture showed an average of largest inhibition zone diameter on 50% concentration with 20,5 mm diameter and smallest inhibition zone at 6,25% concentration with 14 mm diameter.
Co-Authors Andang Arif Wibawa Nisa’ Nur Sholikhah