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Molly Dumakuri Oktarina
Metropolitan Medical Center (MMC) Hospital, Jakarta, Indonesia
Medicine & Pharmacology Public Health

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Experts’ Opinion on Immunity and Nutrition to Support Key Cognitive Functions Rini Sekartini; Juwalita Surapsari; Molly Dumakuri Oktarina; Tjhin Wiguna; Taufiq Fredrik Pasiak; Ray Wagiu Basrowi; Melissa Stephanie Kartjito; Erika Wasito
World Nutrition Journal Vol. 6 No. S2 (2023): Volume 06 Supplement 2, May 2023
Publisher : Indonesian Nutrition Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25220/WNJ.V06.S2.0001

Abstract

The interaction of micronutrients and macronutrients has been shown to have a significant impact on children's cognitive development. Furthermore, proper nutrition helps a child's immune system avoid infection and disease, which can impair nutrient absorption and lead to deficiency. Microbiotas in the gut play critical roles in body physiology, including nutrient absorption, infection resistance and immune system development. Furthermore, it is known that the gut microbiota influences immune cell maturation. Finally, these three factors are thought to influence neurogenesis and cognitive development. A virtual meeting was held with five invited experts to gain a better understanding of the relationship between nutritional factors, the immune system and cognitive development.
Evidence on the importance of gut microbiota for the immune system Juwalita Surapsari; Molly Dumakuri Oktarina; Tonny Sundjaya; Erika Wasito
World Nutrition Journal Vol. 6 No. S2 (2023): Volume 06 Supplement 2, May 2023
Publisher : Indonesian Nutrition Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25220/WNJ.V06.S2.0002

Abstract

Vital to the health of the host is maintaining a delicate balance in the immune system by eliminating harmful pathogens while preserving self-tolerance to prevent autoimmunity. By regulating immune homeostasis, the gut microbiota in the gastrointestinal tract provides vital health benefits to its host. It has been demonstrated conclusively that dysbiosis of these gut microbial communities can cause immune dysregulation and autoimmunity. We attempt to examine the relationship between the gut microbiota and the regulation of the innate and adaptive immune homeostasis, which can influence the development of certain disease. This literature review of recently published research and newly discovered scientific information is intended to increase awareness of the importance of maintaining a microbiota balance in the gut for immune health of the host.
Immunity as key factors that influence cognitive development on children Molly Dumakuri Oktarina; Rini Sekartini; Erika Wasito; Melissa Stephanie Kartjito
World Nutrition Journal Vol. 6 No. S2 (2023): Volume 06 Supplement 2, May 2023
Publisher : Indonesian Nutrition Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25220/WNJ.V06.S2.0003

Abstract

Immune cells in the central nervous system (CNS) of the fetus are essential for normal neurodevelopment. Innate immunity-related molecules, including cytokines, toll-like receptors and complement family, are known to be expressed in the brain. Microglia, macrophage-like immune cells that reside in the brain and spinal cord, constitute 80% of all immune cells in the brain, making them the most abundant immune cell type. Acquired immunity-related molecules, such as major histocompatibility complex and antibody receptor, are also known to be expressed in the brain. In addition to this, research has demonstrated that they play important functions in the development of the brain. Neurodevelopmental diseases, including schizophrenia, autism spectrum disorders, autism-like obsessive-compulsive behaviours and social impairment, are characterized by a disruption of a wide variety of processes in the developing brain that depend on the normal function of microglia. Enteric infections and malnutrition in the first two years of life are linked to later cognitive impairment. Multiple studies have shown that bacterial and viral illnesses have direct or indirect impacts on cognitive performance in children. The immune system is in constant communication with the central nervous system and participates in the control of behaviour and a range of other essential neurological activities throughout the lifespan.
Co-Authors Erika Wasito Erika Wasito Juwalita Surapsari Melissa Stephanie Kartjito Ray Wagiu Basrowi Rini Sekartini Taufiq Fredrik Pasiak Tjhin Wiguna Tonny Sundjaya