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Singh, N.P
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The Prevalence of Hepatitis A Virus and Hepatitis E Virus in a tertiary care hospital, East Delhi, India.: Charu Jain , Nikita Birhman , Shukla Das , Swati Sinha, N.P. Singh Jain, Charu; Birahman, Nikita; Das, Sukhla; Sinha, Swati; Singh, N.P
Jurnal Ilmu Kesehatan dan Kesehatan Vol 7 No 01 (2023): FEBRUARY
Publisher : UNUSA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/mhsj.v7i01.3807

Abstract

Background & Aim: Acute viral hepatitis (AVH) is a condition that is known to be caused by enterically transmitting Hepatitis A virus (HAV) and Hepatitis E virus (HEV). Usually, they result in self-limiting disease but can be seriously threatening if complications arise. This study was done to determine the prevalence rate of HAV and HEV in a tertiary care hospital in East Delhi, India. Material & Methods: The retrospective and observational study of 2-year duration was conducted in the Department of Microbiology at UCMS and GTBH Delhi, India. A total of 410 samples from patients presenting with a clinical diagnosis of acute hepatitis were considered in the study. The serum samples were analysed for IgM anti-HAV and IgM anti-HEV, respectively, using commercially available ELISA kits. Results: The seroprevalence of HAV and HEV were 2.19% and 0.24%, respectively. No case was found to be reactive for both parameters, indicating no case of co-infection. The majority of clinical samples were from female patients. Conclusion: The incidence of HEV and HAV illnesses suggests that East Delhi has a lower prevalence rate of the reported viral illnesses. This finding suggests one of the following: limited circulation of the agents, good sanitary conditions, and/or protective immunity among the population tested. Nonetheless, we should continue to assess the ongoing conditions and take measures to improve them.
In-vitro Susceptibility Testing of Dermatophytes Isolated in Delhi (India) Against Five Antifungal Drugs Datt, Shyama; Datt, Thakur; Singh, N.P
Jurnal Ilmu Kesehatan dan Kesehatan Vol 8 No 02 (2024): AUGUST
Publisher : UNUSA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/mhsj.v8i02.5727

Abstract

Background: Over the past few decades, cases of dermatophytosis have been on the rise. Recently, the introduction of newer, less toxic antifungal drugs has improved treatment options. However, the prolonged use of antifungals has led to the emergence of acquired resistance among strains that were previously susceptible, as well as an increase in infections caused by less common species. This scenario underscores the growing need for rapid and accurate antifungal susceptibility testing methods. In this study, antifungal susceptibility was assessed using the in-vitro micro broth dilution method, adhering to the CLSI M38-A guidelines Methods: 60 clinical specimens were collected from Nail and skin of the patients of dermatophytosis from Delhi (India). Minimal inhibitory concentration (MIC) was performed in microtiter plates with U-bottom and incubated at 35° C. Reading were taken after 48 & 96 hrs of incubation for Trichophyton mentagrophytes and Trichophyton rubrum, against 5 antifungal drugs namely fluconazole, itraconazole (triazoles), griseofulvin, terbinafine and Luliconazole. Results: Most of the dermatophytes had uniform patterns of susceptibility to the antifungal agents tested. Low MIC values as 0.03μg/mL were found for 33.3%, 31.6% and 15% of isolates for itraconazole and terbinafine, respectively. Conclusion: In conclusion, it may be useful to undertake periodical screening programs to detect the antifungal susceptibility of newer antifungal agents.
Co-Authors Birahman, Nikita Das, Sukhla Datt, Shyama Datt, Thakur Jain, Charu Sinha, Swati