Article Per Year (5 Year)
p-Index From 2020 - 2025
0.408
P-Index
This Author published in this journals
All Journal Journal Pharmaceutical Science and Application (JPSA)
Sanan, Antonius Oenunu
Unknown Affiliation
Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health

Published : 2 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 2 Documents
Search

 1 
TRACING OF SECONDARY METABOLITES AND ANTIMICROBIAL ACTIVITY OF SAPINDACEAE AS AN EFFORT TO PRESERVE HERBAL PLANTS: A REVIEW Sanan, Antonius Oenunu; Hertiani, Triana; Murti, Yosi Bayu
Journal Pharmaceutical Science and Application Vol 6 No 1 (2024): Journal Pharmaceutical Science and Application
Publisher : Departement of Pharmacy, Faculty of Mathematic and Natural Science, Udayana University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JPSA.2024.v06.i01.p01

Abstract

Background: Sapindaceae plants in the community are used to treat various diseases. This plant is traced to contain secondary metabolites with various pharmacological activities, including antimicrobials. Objective: This review article aims to provide information about Sapindaceae plants with antimicrobial potential and summarize the content of secondary metabolite compounds. Methods: This review article uses sources from international and national journals obtained by online search and considers two criteria, namely inclusion and exclusion. Then, it was further selected to obtain data in the form of secondary metabolites that can potentially be antimicrobial. Results: Some parts of the Sapindaceae plant contain essential secondary metabolites such as alkaloids, flavonoids, phenols, tannins, saponins, and triterpenoids. These secondary metabolites have a potential pharmacological activity that has been tested against antimicrobials. Conclusion: Sapindaceae plants contain diverse secondary metabolites and have antimicrobial activity. Further research is needed to explore other Sapindaceae plant species to find compounds and other pharmacological activities to address various diseases in the community. Keywords: Sapindaceae; Secondary metabolite component; Antimicrobial Activity.
CHARACTERIZATION OF ANTIBACTERIAL BIOACTIVE COMPOUNDS FROM KUSAMBI LEAF EXTRACT (Schleichera oleosa (L) Oken) Sanan, Antonius Oenunu; Murti, Yosi Bayu; Hertiani, Triana
Journal Pharmaceutical Science and Application Vol 6 No 1 (2024): Journal Pharmaceutical Science and Application
Publisher : Departement of Pharmacy, Faculty of Mathematic and Natural Science, Udayana University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JPSA.2024.v06.i01.p03

Abstract

Background: The kusambi plant is traditionally used by people to treat various diseases. This plant is thought to contain various secondary metabolites with various pharmacological activities, including antibacterial. Objectives: This study aims to determine the antibacterial activity of various extracts using n-hexane, ethyl acetate, and 96% methanol as solvents against Staphylococcus aureus ATCC 25923 and Escherichia coli ATCC 25922 bacteria and identify what groups of compounds are contained in the kusambi leaf extract. Method: Kusambi leaves were extracted with Soxhlet using n-hexane, ethyl acetate, and 96% methanol (1:4 w/v). Activity testing uses the agar diffusion method, and compound class testing uses the TLC (thin layer chromatography) method and spray reagents. Results: The research showed the highest yield was 22% for methanol extract, 12% for N-hexane extract, and 20% for ethyl acetate extract. Methanol extract activity test Kusambi leaves show moderate intensity inhibitory activity against bacteria S.aureus bacteria, while bacteria E.coli did not show inhibitory activity. The most significant inhibition zone diameter in the ethyl acetate extract was 9.22 mm with a concentration of 10?g/mL, the methanol extract had an inhibition zone diameter of 8.82 mm with a concentration of 10 ?g/mL, and the leaf N-hexane extract had no inhibition zone. The identification results of the compound groups were flavonoids, alkaloids, phenols, steroids, and triterpenoids, as proven by the TLC method and spray reagents. Conclusion: Kusambi leaf extract using ethyl acetate solvent has inhibitory activity against bacteria S.aureus and contains flavonoids, phenols, steroids, alkaloids, and triterpenoids. Keywords: Kusambi plant; antibacterial; secondary metabolite compounds.
Co-Authors Triana Hertiani Yosi Bayu Murti