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All Journal Jurnal Kedokteran Diponegoro Interdisciplinary Social Studies
seran, Bernadetha kusuma kris firmantya tei
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Environmental Science Languange, Linguistic, Communication & Media Medicine & Pharmacology Public Health Social Sciences

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Risk Stratification Tools in Predicting Survival and Transformation of Therapy-Related Myelodysplastic Syndrome: A Systematic Review Rubiyat, Siti; seran, Bernadetha kusuma kris firmantya tei; Rustamadji, Albert Tri
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 13, No 5 (2024): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v13i5.46210

Abstract

Background: Therapy-related myelodysplastic syndromes (t-MDS) are grouped with therapy-related acute lymphoblastic leukemia (t-ALL) and therapy-related myelodysplastic/myeloproliferative neoplasms (t-MDS/MPN) under therapy-related myeloid neoplasms (t-MNs). Most myelodysplastic syndrome (MDS) prognostic models have excluded t-MDS patients, leaving their prognostic utility uncertain. Objective: This systematic review aims to synthesize the predictive utility of existing and novel risk stratification tools in assessing the survival and transformation of t-MDS. Methods: Searches were conducted in PubMed and ScienceDirect following PRISMA 2020 guidelines, focusing on overall survival and transforming t-MDS into acute myeloid leukemia (AML). Two reviewers independently screened references, extracted data, and assessed quality using the QUAPAS-2 tool. Results: From 1715 abstracts and 13 papers, 6 studies were included. Three studies on the International Prognostic Scoring System (IPSS) showed significant predictive power for survival and AML transformation. Five studies on the revised IPSS (IPSS-R) and WHO-based Prognostic Scoring System-revised (WPSS-R) also showed significant results. One study highlighted the cytogenetic component of IPSS-R (cIPSS-R) as highly prognostic. Conclusion: Existing and novel risk stratification tools demonstrate significant prognostic power for t- MDS. Further refinement and validation are needed to enhance risk assessment and treatment strategies. 
Preseptal Cellulitis In A 54-Year-Old Woman With Uncontrolled Diabetes Mellitus: A Case Report Satari, Adam Primadona; Seran, Bernadetha Kusuma Kris Firmantya Tei; Juwita, Oktarina Nila
Interdisciplinary Social Studies Vol. 4 No. 4 (2025): Regular Issue: July-September 2025
Publisher : International Journal Labs

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55324/iss.v4i4.933

Abstract

Preseptal cellulitis is a skin infection around the eye that can originate from various sources such as sinusitis or trauma. This study explores the case of a 54-year-old patient with uncontrolled type 2 diabetes who presented with preseptal cellulitis. The patient complained of redness and pain around the left eye, with a history of fever and swelling for three days prior. Physical examination revealed hyperemic edema on the upper eyelid of the left eye with positive tenderness. Additionally, the patient had a history of uncontrolled type 2 diabetes. CT-scan imaging of the orbit and paranasal sinuses revealed hyperpigmentation on the left extraocular bulb, opacity in the right maxillary sinus with a polyp impression, and a hyperdense lesion in the right maxillary sinus with evidence of hyperostosis of the right maxillary bone. Laboratory results showed hyperglycemia, leukocytosis, uremia, and increased creatinine. The established diagnosis was preseptal cellulitis with potential complications. The discussion involves clinical aspects and management of preseptal cellulitis, including orbital anatomy, infection spread, diagnosis, and treatment. Patient management included the administration of antibiotics, anti-inflammatory drugs, and glycemic control. This study emphasizes the importance of research into the relationship between type 2 diabetes and preseptal cellulitis for a better understanding of risk factors and optimal management. In conclusion, this research provides in-depth insights into the complexity and risks of preseptal cellulitis in patients with uncontrolled type 2 diabetes and underscores the need for proper management to reduce complications in this condition.
Co-Authors Juwita, Oktarina Nila Rubiyat, Siti Rustamadji, Albert Tri Satari, Adam Primadona