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Journal : SCRIPTA SCORE Scientific Medical Journal

Low Oxalate Diet for Prevention of Kidney Stone Disease: A Literature Review Alhamdi, Mochammad Haikal; Alimah, Ghina Jilan
SCRIPTA SCORE Scientific Medical Journal Vol. 6 No. 1 (2024): SCRIPTA SCORE Scientific Medical Journal
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/scripta.v6i1.16080

Abstract

Background: Nephrolithiasis is the most common illness affecting the urinary system. It affects 600,000 Americans annually and about 12% of the world's population. It caused by a concentration of crystals that exits the kidney and genitourinary system. Calcium stones, primarily composed of calcium phosphate or oxalate, are present in about 80% of patients with nephrolithiasis. Kidney stones can be avoided by controlling the production of oxalate stones through the low oxalate dietary sources and regulating other factors that affect oxalate absorption. Objectives: The purpose of this literature review is to explain how to maintain a low-oxalate diet and other factors, such as enzymes, oxalate precursors, and bacteria in the colon, affect urine oxalate excretion and help prevent the formation of kidney stones. Methods: A summary of this literature was compiled using data from numerous internet resources. Ten earlier research RCTs or observational studies with statistical analysis—that met a number of inclusion criteria were used to support the goals of this work. The journal is available for open access, its publication year is at least 2014. Discussion: Consuming more water, DASH, low calcium and salt diet, and a low-oxalate diet can all considerably reduce the excretion of oxalate. Conversely, a poor dietary pattern has been associated with an increased risk of kidney stones. Oral formulations ALLN-177, Oxabact, and OxDC are helpful in lowering urinary oxalate levels. Conclusion: Kidney stone disease may be avoided by adopting a low-oxalate and low-precursor diet. Latar Belakang: Nefrolitiasis merupakan penyakit yang banyak terjadi pada sistem saluran kemih. Penyakit ini mempengaruhi 600.000 orang Amerika setiap tahunnya dan sekitar 12% populasi dunia. Hal ini disebabkan oleh peningkatan konsentrasi kristal di sistem genitourinari.  Pada pasien nefrolitiasis, 80% diantaranya disebabkan oleh pembentukan batu kalsium, terutama fosfat atau oksalat. Nefrolitiasis dapat dihindari dengan mengendalikan produksi batu oksalat melalui sumber makanan rendah oksalat dan mengatur faktor lain yang mempengaruhi penyerapan oksalat.Tujuan: Penulisan literatur ditujukan untuk mengetahui pengaturan pola makan rendah oksalat dan faktor lain seperti enzim, prekursor oksalat dan bakteri di usus sebagai pencegahan pembentukan batu oksalat di ginjal dengan menurunkan eksresi oksalat dalam urin. Metode: Literature review dilakukan dengan mengumpulkan berbagai literatur bersumber dari Internet. Digunakan 10 penelitian yang sesuai dengan kriteria inklusi, penelitian RCT ataupun studi observasional, artikel memiliki akses gratis, tahun terbit minimal 2014 Diskusi: Peningkatan konsumsi air, DASH, diet rendah kalsium dan rendah garam dapat menurunkan eksresi oksalat. Pola diet yang buruk dapat meningkatkan risiko pembentukan batu ginjal. Konsumsi ALLN-177, Oxabact dan OxDC membantu menurunkan oksalat urin. Kesimpulan: Pembentukan batu ginjal dapat dihindari dengan menerapkan pola makan rendah oksalat dan rendah prekursor oksalat.
Comparison of Success Rates between Buccal Mucosal Graft and Penile Skin Graft in Anterior Urethral Stricture Repair: A Systematic Review Alhamdi, Mochammad Haikal
SCRIPTA SCORE Scientific Medical Journal Vol. 7 No. 2 (2026): SCRIPTA SCORE Scientific Medical Journal
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/scripta.v7i2.23471

Abstract

Background: Anterior urethral stricture is a common urologic condition that may require substitution urethroplasty when endoscopic treatment fails. Buccal mucosal graft (BMG) and penile skin graft/flap (PSG/PSF) are established options, but their comparative success remains debated. Objective: To compare the success and safety outcomes of BMG and PSG/PSF urethroplasty in adult males with anterior urethral stricture. Methods: A systematic review was conducted following PRISMA 2020 guidelines. Databases searched included PubMed, Embase, Scopus, Web of Science, and Cochrane Library for studies published between 2015 and 2025. Randomized controlled trials, comparative cohorts, and meta-analyses evaluating BMG versus PSG/PSF urethroplasty were included. Twelve studies met inclusion criteria and were analyzed narratively. Results: Both graft types showed comparable success and stricture-free rates (85–94%) with no significant difference in recurrence or urinary flow improvement. BMG was favored in patients with lichen sclerosus due to resistance to dermal inflammation, whereas PSG/PSF was suitable when oral harvest was contraindicated. Donor-site morbidity was mild and self-limiting in both groups. Conclusion: Buccal mucosal and penile skin graft urethroplasty yield equivalent outcomes in anterior urethral stricture repair. Graft selection should be individualized based on patient condition and surgeon expertise. Further multicentre randomized studies with standardized outcome definitions are required to confirm long-term differences. Keywords: anterior urethral stricture, buccal mucosal graft, penile skin graft, urethroplasty, reconstruction surgery. Latar Belakang: Striktur uretra anterior merupakan kelainan urologis yang memerlukan urethroplasty substitusi bila terapi endoskopi gagal. Cangkok mukosa bukal (BMG) dan cangkok kulit penis (PSG/PSF) merupakan pilihan utama, namun perbandingan keberhasilannya masih diperdebatkan. Tujuan: Membandingkan keberhasilan dan keamanan urethroplasty menggunakan BMG dan PSG/PSF pada pria dewasa dengan striktur uretra anterior. Metode: Tinjauan sistematik dilakukan berdasarkan pedoman PRISMA 2020. Basis data PubMed, Embase, Scopus, Web of Science, dan Cochrane Library ditelusuri untuk publikasi tahun 2015–2025. Studi acak terkontrol, kohort komparatif, dan meta-analisis yang menilai BMG versus PSG/PSF disertakan. Sebanyak dua belas studi memenuhi kriteria inklusi dan dianalisis secara naratif. Hasil: Kedua jenis cangkok menunjukkan tingkat keberhasilan dan bebas striktur serupa (85–94%) tanpa perbedaan bermakna pada angka kekambuhan atau peningkatan aliran urin. BMG lebih unggul pada kasus dengan lichen sclerosus, sedangkan PSG/PSF sesuai untuk pasien yang tidak dapat dilakukan pengambilan mukosa oral. Morbiditas donor ringan dan bersifat sementara. Kesimpulan: Cangkok mukosa bukal dan kulit penis memberikan hasil yang sebanding pada rekonstruksi striktur uretra anterior. Pemilihan cangkok sebaiknya disesuaikan dengan kondisi pasien dan pengalaman operator. Diperlukan penelitian acak multisenter dengan definisi hasil yang terstandar untuk evaluasi jangka panjang. Kata Kunci: bedah rekonstruksi, cangkok mukosa bukal, cangkok kulit penis, striktur uretra anterior, urethroplasty.