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All Journal Jurnal Kimia Riset Jurnal ABDINUS : Jurnal Pengabdian Nusantara
Sulisetyawati, Theresia Indah Budhy
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Chemistry Computer Science & IT Economics, Econometrics & Finance Education Environmental Science Industrial & Manufacturing Engineering

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Rumah Imun dan Ambulan Motor sebagai Upaya Pencegahan Stunting dan Sarana Kegawatdaruratan di Desa Pagung Kabupaten Kediri Sulisetyawati, Theresia Indah Budhy; Roestamadji, Retno Indrawati; Megasari, Ni Luh Ayu; Imannia, Ristya Sylva; Wardhani, Renita Gusti; Maulanasari, Ersa Afifah; Cheardi, Natallensi Deara; Buana, Dwi Candra
Jurnal ABDINUS : Jurnal Pengabdian Nusantara Vol 8 No 2 (2024): Volume 8 Nomor 2 Tahun 2024
Publisher : Universitas Nusantara PGRI Kediri

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29407/ja.v8i2.23173

Abstract

This community service aims to improve the skills and knowledge of the surrounding community as well as first aid accommodation to health service facilities in the community of Pagung Village, Semen District, Kediri Regency, East Java. The implementation method of this community service is a field survey to identify stunting problems, making pocket books on emergencies and stunting, making motorbike ambulances (LANTOR) to facilitate access to health services, and counseling related to emergencies, balanced nutrition, and stunting. The results of this community service show that counseling and training related to first aid and emergencies can improve the knowledge and skills of the community in Pagung Village, in addition, the provision of "LANTOR" can facilitate and smooth community mobility to the nearest health service facilities.
BIOACTIVE COMPOUNDS OF Moringa oleifera AS KRASG12C INHIBITORS IN COLORECTAL CANCER: IN SILICO STUDY Marviella, Sephia Tiara; Zulqaida, Salma; Sulisetyawati, Theresia Indah Budhy; Ma'ruf, Anwar
Jurnal Kimia Riset Vol. 9 No. 2 (2024): December
Publisher : Universitas Airlangga, Campus C Mulyorejo, Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jkr.v9i2.64871

Abstract

KRAS is a GTPase enzyme that regulates cell growth and division. Mutations in KRAS can lead to its permanent activation, resulting in uncontrolled cell growth and cancer progression. Approximately 30–44% of colorectal cancer cases harbor KRAS mutations, with 1–3% involving the KRASG12C variant. Historically considered "undruggable," recent advancements, such as Sotorasib, have demonstrated the potential to target KRASG12C effectively, making it a promising focus for drug discovery. Moringa oleifera, a plant rich in phytochemicals, is a potential source of bioactive compounds with therapeutic applications. In this study, 218 compounds derived from M. oleifera were screened using molecular docking, targeting KRASG12C. Quercetin (3) exhibited the lowest binding affinity (-9.37 kcal/mol) and showed interactions with key residues, including GLN100A, VAL104A, LYS17A, and TYR97A, suggesting a binding mechanism similar to that of Sotorasib as native ligand. The physicochemical analysis further revealed high gastrointestinal absorption, good lipophilicity, and favorable bioavailability scores for Quercetin (3), supporting its potential as a drug candidate. These findings highlight the potential of M. oleifera compounds, particularly quercetin (3), as inhibitors of KRASG12C in colorectal cancer.
Co-Authors Buana, Dwi Candra Cheardi, Natallensi Deara Imannia, Ristya Sylva Ma'ruf, Anwar Marviella, Sephia Tiara Maulanasari, Ersa Afifah Ni Luh Ayu Megasari Retno Indrawati Roestamadji Wardhani, Renita Gusti Zulqaida, Salma