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All Journal Indonesian Journal of Pharmaceutical Science and Technology Jurnal Ilmu Kefarmasian Indonesia Science Midwifery Jurnal Abdimas Kartika Wijayakusuma Sciences of Pharmacy Medical Sains : Jurnal Ilmiah Kefarmasian
Sodik, Jajang Japar
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Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Computer Science & IT Dentistry Education Health Professions Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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POTENTIAL ANTIOXIDANT ACTIVITY OF SURUHAN LEAF AND STEM EXTRACT (Peperomia pellucida L. Kunth) USING THE DPPH METHOD AND DETERMINATION OF PHENOLIC AND FLAVONOID LEVELS Sodik, Jajang Japar; Budiana, Wempi; Roni, Asep; Wahyudin
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 3 (2024)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v9i3.1264

Abstract

Antioxidants are compounds that are capable of neutralizing free radicals. One plant with potential antioxidant properties is Peperomia pellucida. Objective: This study aimed to determine the antioxidant activity, total phenolic content, and total flavonoid content of extracts of the leaves and stems of Peperomia pellucida. Methods: Antioxidant activity was tested using the DPPH method, while the total phenolic and flavonoid contents were measured using UV-Vis spectrophotometry. Extraction was performed via reflux using three different solvents: n-hexane, ethyl acetate, and ethanol. Results: The highest antioxidant activity was found in the ethanol extract of the leaves, with an IC50 value of 36.85 µg/mL, and in the stems, with an IC50 value of 71.28 µg/mL. The highest total phenolic content in the ethanol extract of the leaves was 14.46 mg GAE/g and that in the stems was 12.82 mg GAE/g. The highest total flavonoid content in the ethanol extract of the leaves was 12.12 mg QE/g and that in the stems was 10.49 mg QE/g. Conclusion: The results indicated that the ethanol extract of Peperomia pellucida leaves exhibited very strong antioxidant activity. Keywords: antioxidants, DPPH, phenolic, flavonoids, suruhan Plants
Peningkatan Pengetahuan Remaja dalam Pencegahan Penyakit Menular Seksual (HIV) di SMK Bhakti Kencana Cimahi dan Soreang Patonah, Patonah; Lisni, Ida; Astuti, Yuli; Wahyudi, Fikri Mourly; Sumbara, Sumbara; Mulyana, Hilman; Sodik, Jajang Japar; Irfani, Abdul Mulki
Jurnal Abdimas Kartika Wijayakusuma Vol 5 No 3 (2024): Jurnal Abdimas Kartika Wijaya Kusuma
Publisher : LPPM Universitas Jenderal Achmad Yani

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26874/jakw.v5i3.450

Abstract

Penyakit HIV/AIDS telah menjadi pandemi global yang mengkhawatirkan, termasuk di Indonesia. Salah satu cara utama penularannya adalah melalui penggunaan jarum suntik pada pengguna narkoba, perilaku yang umum terjadi di kalangan remaja. Kurangnya pengetahuan remaja tentang HIV/AIDS menjadi pemicu utama perilaku berisiko terhadap penyakit ini. Kegiatan pengabdian kepada masyarakat dilakukan di SMK Bhakti Kencana Soreang dan Cimahi dengan tujuan memberikan edukasi tentang pencegahan HIV/AIDS kepada siswa. Kegiatan ini dilaksanakan secara hibrid di dua lokasi sekolah. Kepala sekolah turut serta sebagai mitra, memberikan informasi awal untuk persiapan program edukasi sesuai kebutuhan mitra. Evaluasi keberhasilan kegiatan dilakukan melalui pretest dan post-test terkait pengetahuan dan sikap siswa terhadap HIV/AIDS. Hasil evaluasi menunjukkan peningkatan pengetahuan siswa sebesar 18,7%, mengindikasikan dampak positif dari kegiatan ini dalam meningkatkan pemahaman dan sikap siswa terhadap pencegahan HIV/AIDS.Hasil kegiatan ini dipublikasikan melalui media massa, video YouTube, dan buku saku remaja bebas HIV/AIDS, dengan harapan memberikan dampak yang signifikan dalam pencegahan penularan HIV/AIDS di kalangan remaja.
Evaluation of antipsychotic utilization among outpatient schizoprenia patients at the mental health facility in West Java Sutrisno, Entris; Selifiana, Nita; Sodik, Jajang Japar; Fajarrini, Uvika Nurul
JURNAL ILMU KEFARMASIAN INDONESIA Vol 23 No 1 (2025): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v23i1.1632

Abstract

Rational use of drugs aims to give therapy according to patient’s clinical needs. Based on Ni komang's research (2021) there are still inaccuracies in the use of antipsychotic drugs. The purpose of this study was to determine the evaluation of the use of Antipsychotics based on the parameters of right indications, drugs, dosage, and frequency in outpatient schizophrenia patients at the West Java Provincial Mental Hospital. The study used a method with descriptive presentation of data and retrospective data collection. Data obtained period October-December 2022 from 130 patients, this study evaluated the use of Antipsychotics with the parameters of right indications, drugs, dosage, and frequency then the data will be analyzed based on the criteria for drug use from Pharmacotherapy A Pathophysiologic Approach 11th and PIONAS. The results of the study on the use of Antipsychotics in schizophrenic patients at the Java Provincial Mental Hospital based on Pharmacotherapy A Pathophysiologic Approach 11th and PIONAS obtained the right indications as much as (100%), the right drugs (100%), the right dose (98%), and the right frequency (98%).
Evaluation of Antibiotic Use in Inpatient and Outpatient Diabetic Ulcer Patients at a Government Hospital in Bandung Sutrisno, Entris; Anggriani, Ani; Sodik, Jajang Japar
Sciences of Pharmacy Volume 4 Issue 2
Publisher : ETFLIN Publishing House

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58920/sciphar0402318

Abstract

Diabetic foot ulcers are caused by neuropathy and/or peripheral arterial disease in patients with type 2 diabetes mellitus. These infections are commonly treated with empirical antibiotics. However, excessive or inappropriate antibiotic use may lead to resistance and poor treatment outcomes. This study aimed to evaluate antibiotic prescribing patterns, rationality, and potential drug interactions in diabetic ulcer patients at a government hospital in Bandung from January to December 2023. A retrospective observational design was used to analyze medical records of 63 patients. The most frequently used single antibiotics were ceftriaxone (51%), cefixime (20%), and ceftizoxime (17%), while the most common combination therapy was ceftizoxime + metronidazole (24%). Evaluation of antibiotic rationality showed 100% appropriate indication, 90.48% appropriate drug selection, and 98.41% appropriate dosage. Despite this, 33.33% of prescriptions had potential drug interactions with commonly co-prescribed medications. These findings indicate generally rational antibiotic use with areas for improvement in drug selection and interaction management. The study highlights the importance of continuous monitoring and rational prescribing to prevent antimicrobial resistance and ensure patient safety.
Therapeutic Synergy of Combination of Kaempferia galanga and Zingiber officinale Extracts on Hyperuricemia-Induced Arterial Stiffness Hasimun, Patonah; Muzaki, Yoga Adi Restu; Sodik, Jajang Japar; Sukmawati, Ika Kurnia; Kusriani, Herni
Indonesian Journal of Pharmaceutical Science and Technology Vol 12 (2025): Vol. 12 Suppl. 2 (2025)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v12i0.59175

Abstract

Hyperuricemia, characterized by high uric acid levels, is associated with an elevated risk of cardiovascular diseases. Xanthine oxidoreductase (XOR), an enzyme central to uric acid generation, is implicated in oxidative stress and diminished vascular function. It has become a focal point for potential therapeutic interventions. This investigation aimed to assess the influence of combined ethanol extracts of Kaempferia galanga L. and Zingiber officinale (KGZE) on xanthine oxidase activity and arterial rigidity in hyperuricemic rat models. Furthermore, the research sought to explore these extracts' potential in managing hyperuricemia and its associated vascular disorders. Hyperuricemia was established in Wistar rats by administering potassium oxonate at 4.5 mg/kg via injection. A total of 25 rats were divided into five groups: a normal control group receiving 0.5% CMC, a positive control group with hyperuricemia, a reference group treated with allopurinol (1.8 mg/kgBW), and two experimental groups receiving KGZE at doses of 50 mg/kgBW and 100 mg/kgBW. All rats consumed 25% fructose in their drinking water for 28 days. This study measured uric acid levels and arterial stiffness, revealing that KGZE significantly reduced uric acid levels and improved arterial stiffness, indicating its potential as an XOR inhibitor.
The role of honey, curcuma, and black cumin supplements in overcoming stunting on the adaptive immune system Sabarudin, Cecep; Hasimun, Patonah; Kusriani, Herni; Zuniarto, Ahmad Azrul; Pandanwangi, Siti; Fatmawati, Eva; Afief, Arief R.; Sodik, Jajang Japar
Science Midwifery Vol 13 No 5 (2025): Health Sciences and related fields
Publisher : Institute of Computer Science (IOCS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35335/midwifery.v13i5.2185

Abstract

Stunting is strongly associated with impaired immune function, as chronically malnourished children tend to have weaker immunity and are more vulnerable to infection. This study aimed to examine the effect of temulawak–black cumin herbal honey on the adaptive immune system in stunted children. A quasi-experimental one-group pre-test and post-test design was used. The findings showed that the intervention significantly increased height-for-age (TB/U) in the treatment group compared to the control group (p = 0.014). Weight-for-age (BB/U) also rose significantly within the treatment group (p = 0.013), but no significant difference was found relative to the control group (p = 0.192). The supplement significantly elevated IgM levels in the treatment group (p = 0.001), though again without a significant difference from the control (p = 0.546). CD4 concentration decreased in the treatment group (p = 0.003), but the change was not significantly different from the control (p = 0.682). In conclusion, temulawak–black cumin herbal honey can improve nutritional status and enhance adaptive immunity by increasing IgM levels, although it does not raise CD4 levels and instead slows CD4 decline. However, its effectiveness in increasing IgM and CD4 concentrations compared to controls is not significant.
Co-Authors Afief, Arief R. Ani Anggriani, Ani Budiana, Wempi Fajarrini, Uvika Nurul Fatmawati, Eva Hasimun, Patonah Hilman Mulyana, Hilman Ida Lisni Irfani, Abdul Mulki Muzaki, Yoga Adi Restu Patonah, Patonah Roni, Asep Sabarudin, Cecep Selifiana, Nita Siti Pandanwangi TW Sukmawati, ika kurnia Sumbara Sumbara Sutrisno, Entris Wahyudi, Fikri Mourly Wahyudin Yuli Astuti Zuniarto, Ahmad Azrul