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All Journal Jurnal Biologi Tropis Lombok Medical Journal
Adam Trojan Alisyahbana
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Mechanical Engineering Public Health

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Journal : Jurnal Biologi Tropis

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The Marine Organisms as Potential Sources of Inhibits ACE on Hypertension Patient Alma Dyah Perwita; Adam Trojan Alisyahbana; Adinda Ilsa Maulida; Alfia Mawaddah; Ali Ramzi; Legis Ocktaviana Saputri
Jurnal Biologi Tropis Vol. 23 No. 1 (2023): Special Issue
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v23i1.6162

Abstract

Abstract: Hypertension is a condition of chronic high blood pressure in the systemic arteries which is a major risk factor for cardiovascular disease, kidney disorders, and death. There are two types of hypertension, the primary hypertension is thought to be caused by hereditary factors, age, gender, race, and an unhealthy lifestyle. Secondary hypertension is caused by an obvious cause. The prevalence of hypertension in Indonesia is quite high with the highest incidence rate in South Kalimantan (44,1%) and the lowest in Papua (22,2%). The pathophysiology of hypertension involves the enzyme Angiotensin Converting Enzyme (ACE) which plays a role in regulating blood pressure. The process of converting Angiotensinogen to Angiotensin I, then Angiotensin II by ACE can cause vasoconstriction and fluid retention, which contribute to hypertension. The changes in circulation and blood vessel structure have played a role in the risk of hypertension complications, including stroke. The marine organisms such as fish, shellfish, cephalopods, seaweed, and algae contain peptides with antihypertensive, anticoagulant, antithrombotic, and hypercholesterolemic activities. For example, hydrolyzate of the jellyfish, Rhopilema esculentum can inhibit ACE with a high level of effectiveness. The current hypertension treatment often uses synthetic drugs such as ACE inhibitors and Angiotensin Receptor Blockers (ARBs), but these have undesirable side effects. Therefore, bioactive peptides from marine organisms can be an efficient and safe natural alternative. The research on protein hydrolysates from various sources has found ACE inhibitory activity and several peptides such as Trp-Pro-Met-Gly-Phe (WPMGF) and APP, KPLL, and VYPFPGPIPNSLPQNIPP were identified to have strong ACE inhibitory activity. These findings indicate the potential use of bioactive peptides from marine organisms as a natural alternative for the treatment and prevention of hypertension.
Co-Authors Adinda Ilsa Maulida Akelba, Shalsa Damai Alfia Mawaddah Ali Ramzi Alma Dyah Perwita Aulia Dwi Hendriani Baiq Ramdhani Amelia Negara Grandis Cristagalli1, Izza Mufida Indah Sapta Wardani M. Andre Darmawan Nadia Safira Ni Putu Visty Wedhiani Ocktaviana Saputri, Legis Putu Wika Pramesti Iswari Rike Delya Rizqina Tri Sastra Pradhini